-
1
-
-
84926397340
-
Chapter 36: Computer-based prediction models in regulatory toxicology
-
(eds F.-X. Reichl and M. Schwenk), Springer, Heidelberg
-
Steger-Hartmann, T. and Scott, B. (2014) Chapter 36: Computer-based prediction models in regulatory toxicology, in Handbook of Regulatory Toxicology (eds F.-X. Reichl and M. Schwenk), Springer, Heidelberg.
-
(2014)
Handbook of Regulatory Toxicology
-
-
Steger-Hartmann, T.1
Scott, B.2
-
2
-
-
33745191450
-
Use of computer-assisted prediction of toxic effects of chemical substances
-
Simon-Hettich, B., Rothfuss, A., and Steger-Hartmann, T. (2006) Use of computer-assisted prediction of toxic effects of chemical substances. Toxicology, 224, 156-162.
-
(2006)
Toxicology
, vol.224
, pp. 156-162
-
-
Simon-Hettich, B.1
Rothfuss, A.2
Steger-Hartmann, T.3
-
3
-
-
84873046631
-
Guest editorial: advances in computational toxicology.
-
(special issue)
-
Steger-Hartmann, T. (2013) Guest editorial: advances in computational toxicology. Mol. Inform., 32 (1), 9 (special issue).
-
(2013)
Mol. Inform.
, vol.32
, Issue.1
, pp. 9
-
-
Steger-Hartmann, T.1
-
4
-
-
0003069792
-
Risk assessment
-
8th edn (ed. C.D. Klaassen), McGraw-Hill Medical Publishing Division, New York
-
Faustman, E.M. and Omenn, G.S. (2013) Risk assessment, in Casarett and Doull's Toxicology: The Basic Science of Poisons, 8th edn (ed. C.D. Klaassen), McGraw-Hill Medical Publishing Division, New York, pp. 123-125.
-
(2013)
Casarett and Doull's Toxicology: The Basic Science of Poisons
, pp. 123-125
-
-
Faustman, E.M.1
Omenn, G.S.2
-
5
-
-
0023856614
-
Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP
-
Ashby, J. and Tennant, R.W. (1988) Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP. Mutat. Res., 204, 17-115.
-
(1988)
Mutat. Res.
, vol.204
, pp. 17-115
-
-
Ashby, J.1
Tennant, R.W.2
-
6
-
-
0039712065
-
Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma
-
Knudson, A.G., Hethcote, H.W., and Brown, B.W. (1975) Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma. Proc. Natl. Acad. Sci. USA, 72, 5116-5120.
-
(1975)
Proc. Natl. Acad. Sci. USA
, vol.72
, pp. 5116-5120
-
-
Knudson, A.G.1
Hethcote, H.W.2
Brown, B.W.3
-
7
-
-
33645840463
-
A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity
-
Müller, L., Mauthe, R.J., Riley, C.M., Andino, M.M., De Antonis, D., Beels, C., DeGeorge, J., De Knaep, A.G.M., Ellison, D., Fagerland, J.A., Frank, R., Fritschel, B., Galloway, S., Harpur, E., Humfrey, C.D.N., Jacks, A.S.J., Jagota, N., Mackinnon, J., Mohan, G., Ness, D.K., O'Donovan, M.R., Smith, M.D., Vudathala, G., and Yotti, L. (2006) A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity. Regul. Toxicol. Pharmacol., 44, 198-211.
-
(2006)
Regul. Toxicol. Pharmacol.
, vol.44
, pp. 198-211
-
-
Müller, L.1
Mauthe, R.J.2
Riley, C.M.3
Andino, M.M.4
De Antonis, D.5
Beels, C.6
DeGeorge, J.7
De Knaep, A.G.M.8
Ellison, D.9
Fagerland, J.A.10
Frank, R.11
Fritschel, B.12
Galloway, S.13
Harpur, E.14
Humfrey, C.D.N.15
Jacks, A.S.J.16
Jagota, N.17
Mackinnon, J.18
Mohan, G.19
Ness, D.K.20
O'Donovan, M.R.21
Smith, M.D.22
Vudathala, G.23
Yotti, L.24
more..
-
8
-
-
10744227159
-
Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet
-
Kroes, R., Renwick, A.G., Cheeseman, M., Kleiner, J., Mangelsdorf, I., Piersma, A., Schilter, B., Schlatter, J., van Schothorst, F., Vos, J.G., and Würtzen, G. (2004) Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet. Food Chem. Toxicol., 42, 65-83.
-
(2004)
Food Chem. Toxicol.
, vol.42
, pp. 65-83
-
-
Kroes, R.1
Renwick, A.G.2
Cheeseman, M.3
Kleiner, J.4
Mangelsdorf, I.5
Piersma, A.6
Schilter, B.7
Schlatter, J.8
van Schothorst, F.9
Vos, J.G.10
Würtzen, G.11
-
9
-
-
70349910465
-
Benchmark data set for in silico prediction of Ames mutagenicity
-
Hansen, K., Mika, S., Schroeter, T., Sutter, A., ter Laak, A., Steger-Hartmann, T., Heinrich, N., and Muller, K.R. (2009) Benchmark data set for in silico prediction of Ames mutagenicity. J. Chem. Inf. Model., 49, 2077-2081.
-
(2009)
J. Chem. Inf. Model.
, vol.49
, pp. 2077-2081
-
-
Hansen, K.1
Mika, S.2
Schroeter, T.3
Sutter, A.4
ter Laak, A.5
Steger-Hartmann, T.6
Heinrich, N.7
Muller, K.R.8
-
10
-
-
84903397984
-
Genotoxic impurities M7: assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk
-
EMA/CHMP/ICH/83812/2013
-
International Conference on Harmonisation (2013) Genotoxic impurities M7: assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk. EMA/CHMP/ICH/83812/2013.
-
(2013)
-
-
-
11
-
-
84883451066
-
Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities
-
Sutter, A., Amberg, A., Boyer, S., Brigo, A., Contrera, J.F., Custer, L.L., Dobo, K.L., Gervais, V., Glowienke, S., Gompel, J.V., Greene, N., Muster, W., Nicolette, J., Reddy, M.V., Thybaud, V., Vock, E., White, A.T., and Müller, L. (2013) Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities. Regul. Toxicol. Pharmacol., 67 (1), 39-52.
-
(2013)
Regul. Toxicol. Pharmacol.
, vol.67
, Issue.1
, pp. 39-52
-
-
Sutter, A.1
Amberg, A.2
Boyer, S.3
Brigo, A.4
Contrera, J.F.5
Custer, L.L.6
Dobo, K.L.7
Gervais, V.8
Glowienke, S.9
Gompel, J.V.10
Greene, N.11
Muster, W.12
Nicolette, J.13
Reddy, M.V.14
Thybaud, V.15
Vock, E.16
White, A.T.17
Müller, L.18
-
13
-
-
77951212394
-
Phospholipidosis as a function of basicity, lipophilicity, and volume of distribution of compounds
-
Hanumegowda, U.M., Wenke, G., Regueiro-Ren, A., Yordanova, R., Corradi, J.P., and Adams, S.P. (2010) Phospholipidosis as a function of basicity, lipophilicity, and volume of distribution of compounds. Chem. Res. Toxicol., 23, 749-755.
-
(2010)
Chem. Res. Toxicol.
, vol.23
, pp. 749-755
-
-
Hanumegowda, U.M.1
Wenke, G.2
Regueiro-Ren, A.3
Yordanova, R.4
Corradi, J.P.5
Adams, S.P.6
-
14
-
-
84867493875
-
Construction and consensus performance of (Q)SAR models for predicting phospholipidosis using a dataset of 743 compounds
-
Orogo, A.M., Choi, S.S., Minnier, B.L., and Kruhlak, N.L. (2012) Construction and consensus performance of (Q)SAR models for predicting phospholipidosis using a dataset of 743 compounds. Mol. Inform., 31 (19), 725-739.
-
(2012)
Mol. Inform.
, vol.31
, Issue.19
, pp. 725-739
-
-
Orogo, A.M.1
Choi, S.S.2
Minnier, B.L.3
Kruhlak, N.L.4
-
15
-
-
0347052775
-
The second national toxicology program comparative exercise on the prediction of rodent carcinogenicity: definitive results
-
Benigni, R. and Zito, R. (2004) The second national toxicology program comparative exercise on the prediction of rodent carcinogenicity: definitive results. Mutat. Res., 566, 49-63.
-
(2004)
Mutat. Res.
, vol.566
, pp. 49-63
-
-
Benigni, R.1
Zito, R.2
-
16
-
-
73749088210
-
The Benigni/Bossa rulebase for mutagenicity and carcinogenicity - a module of Toxtree
-
EUR 23241 EN. Available at, last accessed June 20, 2014
-
Benigni, R., Bossa, C., Jeliazkova, N., Netzeva, T., and Worth, A. (2008) The Benigni/Bossa rulebase for mutagenicity and carcinogenicity - a module of Toxtree. EUR 23241 EN. Available at http://ihcp.jrc.ec.europa.eu/our_labs/predictive_toxicology/doc/EUR_23241_EN.pdf (last accessed June 20, 2014).
-
(2008)
-
-
Benigni, R.1
Bossa, C.2
Jeliazkova, N.3
Netzeva, T.4
Worth, A.5
-
17
-
-
23744479852
-
Skin sensitization: modeling based on skin metabolism simulation and formation of protein conjugates
-
Dimitrov, S.D., Low, L.K., Patlewicz, G.Y., Kern, P.S., Dimitrova, G.D., Comber, M. H., Niemla, J., Bailey, P.T., and Mekenyan, O.G. (2005) Skin sensitization: modeling based on skin metabolism simulation and formation of protein conjugates. Int. J. Toxicol., 24, 189-204.
-
(2005)
Int. J. Toxicol.
, vol.24
, pp. 189-204
-
-
Dimitrov, S.D.1
Low, L.K.2
Patlewicz, G.Y.3
Kern, P.S.4
Dimitrova, G.D.5
Comber, M.H.6
Niemla, J.7
Bailey, P.T.8
Mekenyan, O.G.9
-
18
-
-
84887828102
-
Computer models versus reality: how well do in silico models currently predict the sensitization of a substance
-
Teubner, W., Mehling, A., Schuster, P.X., Guth, K., Worth, A., Burton, J., van Ravenzwaay, B., and Landsiedel, R. (2013) Computer models versus reality: how well do in silico models currently predict the sensitization of a substance. Regul. Toxicol. Pharmacol., 67 (3), 468-485.
-
(2013)
Regul. Toxicol. Pharmacol.
, vol.67
, Issue.3
, pp. 468-485
-
-
Teubner, W.1
Mehling, A.2
Schuster, P.X.3
Guth, K.4
Worth, A.5
Burton, J.6
van Ravenzwaay, B.7
Landsiedel, R.8
-
19
-
-
84860073322
-
OECD Guideline for the Testing of Chemicals: Acute Dermal Irritation/Corrosion
-
OECD/OCDE 404
-
Organisation for Economic Co-operation and Development (2002) OECD Guideline for the Testing of Chemicals: Acute Dermal Irritation/Corrosion. OECD/OCDE 404.
-
(2002)
-
-
-
20
-
-
0033739877
-
Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Creation of fundamental rules for a decision support system
-
Gerner, I., Zinke, S., Graetschel, G., and Schlede, E. (2000) Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Creation of fundamental rules for a decision support system. Altern. Lab. Anim., 28 (5), 665-698.
-
(2000)
Altern. Lab. Anim.
, vol.28
, Issue.5
, pp. 665-698
-
-
Gerner, I.1
Zinke, S.2
Graetschel, G.3
Schlede, E.4
-
21
-
-
84926400265
-
ToxTree
-
Available at, last accessed June 20, 2014
-
Joint Research Centre, Institute for Health and Consumer Protection (2013) ToxTree. Available at http://ihcp.jrc.ec.europa.eu/our_labs/predictive_toxicology/qsar_tools/toxtree (last accessed June 20, 2014).
-
(2013)
-
-
-
22
-
-
9144271815
-
Searching chemical structures
-
(eds J. Gasteiger and T. Engel), John Wiley & Sons, Ltd, Chichester
-
Kochev, N., Monev, V., and Bangov, I. (2003) Searching chemical structures, in Chemoinformatics - A Textbook (eds J. Gasteiger and T. Engel), John Wiley & Sons, Ltd, Chichester, pp. 291-316.
-
(2003)
Chemoinformatics - A Textbook
, pp. 291-316
-
-
Kochev, N.1
Monev, V.2
Bangov, I.3
-
23
-
-
22044433824
-
Assessment of the eye irritating properties of chemicals by applying alternatives to the Draize rabbit eye test: the use of QSARs and in vitro tests for the classification of eye irritation
-
Gerner, I., Liebsch, M., and Spielmann, H. (2005) Assessment of the eye irritating properties of chemicals by applying alternatives to the Draize rabbit eye test: the use of QSARs and in vitro tests for the classification of eye irritation. Altern. Lab. Anim., 33, 215-237.
-
(2005)
Altern. Lab. Anim.
, vol.33
, pp. 215-237
-
-
Gerner, I.1
Liebsch, M.2
Spielmann, H.3
-
24
-
-
0018079206
-
Estimation of toxic hazard - decision tree approach
-
Cramer, G.M., Ford, R.A., and Hall, R.L. (1976) Estimation of toxic hazard - decision tree approach. Food Cosmet. Toxicol., 16, 255-276.
-
(1976)
Food Cosmet. Toxicol.
, vol.16
, pp. 255-276
-
-
Cramer, G.M.1
Ford, R.A.2
Hall, R.L.3
-
25
-
-
8844236997
-
Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
-
Contrera, J.F., Matthews, E.J., Kruhlak, N. L., and Benz, R.D. (2004) Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose. Regul. Toxicol. Pharmacol., 40, 185-206.
-
(2004)
Regul. Toxicol. Pharmacol.
, vol.40
, pp. 185-206
-
-
Contrera, J.F.1
Matthews, E.J.2
Kruhlak, N.L.3
Benz, R.D.4
-
26
-
-
84892955302
-
Hybrid in silico models for drug-induced liver injury using chemical descriptors and in vitro cell-imaging information
-
Zhu, X.W., Sedykh, A., and Liu, S.S. (2014) Hybrid in silico models for drug-induced liver injury using chemical descriptors and in vitro cell-imaging information. J. Appl. Toxicol., 34 (3), 281-288.
-
(2014)
J. Appl. Toxicol.
, vol.34
, Issue.3
, pp. 281-288
-
-
Zhu, X.W.1
Sedykh, A.2
Liu, S.S.3
-
27
-
-
70249084706
-
Guidance for Industry: Drug-Induced Liver Injury: Premarketing Clinical Evaluation
-
U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER)
-
Food and Drug Administration (2009) Guidance for Industry: Drug-Induced Liver Injury: Premarketing Clinical Evaluation. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER).
-
(2009)
-
-
-
28
-
-
84926399356
-
Adverse Outcome Pathways, Molecular Screening and Toxicogenomics
-
Available at, last accessed June 20, 2014
-
Organisation for Economic Co-operation and Development (2013) Adverse Outcome Pathways, Molecular Screening and Toxicogenomics. Available at http://www.oecd.org/env/ehs/testing/molecularscreeningandtoxicogenomics .htm (last accessed June 20, 2014).
-
(2013)
-
-
-
29
-
-
84894281260
-
The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins. Part 1: Scientific Evidence
-
OECD Environment, Health and Safety Publications, Series on Testing and Assessment, No. 168
-
Organisation for Economic Co-operation and Development (2012) The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins. Part 1: Scientific Evidence. OECD Environment, Health and Safety Publications, Series on Testing and Assessment, No. 168.
-
(2012)
-
-
-
30
-
-
84884179017
-
The adverse outcome pathway concept: a pragmatic tool in toxicology
-
Vinken, M. (2013) The adverse outcome pathway concept: a pragmatic tool in toxicology. Regul. Toxicol. Pharmacol., 312, 158-165.
-
(2013)
Regul. Toxicol. Pharmacol.
, vol.312
, pp. 158-165
-
-
Vinken, M.1
-
31
-
-
84926397339
-
-
Available at, last accessed June 20
-
Nuclear Regulatory Commission (NRC). Available at http://www.nrc.gov/readingrm/basic-ref/glossary/risk.html (last accessed June 20, 2014).
-
(2014)
-
-
-
32
-
-
33748319204
-
Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers
-
U.S. Department of Health and Human Services, Center for Drug Evaluation and Research (CDER)
-
Food and Drug Administration (2005) Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers. U.S. Department of Health and Human Services, Center for Drug Evaluation and Research (CDER).
-
(2005)
-
-
-
33
-
-
84926397338
-
-
Available at, last accessed June 20
-
National Toxicology Program. Available at http://ntp.niehs.nih.gov/? objectid=72016E39-BDB7-CEBAFF0CB5AFEA7887A2 (last accessed June 20, 2014).
-
(2014)
-
-
-
34
-
-
23944460899
-
Towards the creation of an international toxicology information centre
-
Judson, P.N., Cooke, P.A., Doerrer, N.G., Greene, N., Hanzlik, R.P., Hardy, C., Hartmann, A., Hinchliffe, D., Holder, J., Müller, L., Steger-Hartmann, T., Rothfuss, A., Smith, M., Thomas, K., Vessey, J.D., and Zeiger, E. (2005) Towards the creation of an international toxicology information centre. Toxicology, 213, 117-128.
-
(2005)
Toxicology
, vol.213
, pp. 117-128
-
-
Judson, P.N.1
Cooke, P.A.2
Doerrer, N.G.3
Greene, N.4
Hanzlik, R.P.5
Hardy, C.6
Hartmann, A.7
Hinchliffe, D.8
Holder, J.9
Müller, L.10
Steger-Hartmann, T.11
Rothfuss, A.12
Smith, M.13
Thomas, K.14
Vessey, J.D.15
Zeiger, E.16
-
35
-
-
84926397337
-
-
Available at, last accessed June 20
-
The Carcinogenic Potency Database. Available at http://toxnet.nlm.nih.gov/cpdb/(last accessed June 20, 2014).
-
(2014)
-
-
-
36
-
-
84926397336
-
-
Available at, last accessed June 20
-
International Uniform Chemical Information Database. Available at http://iuclid.eu/index.php? fuseaction=home.iuclidHome (last accessed June 20, 2014).
-
(2014)
-
-
-
37
-
-
33750632189
-
REPDOSE: a database on repeated dose toxicity studies of commercial chemicals - a multifunctional tool
-
Bitsch, A., Jacobi, S., Melber, C., Wahnschaffe, U., Simetska, N., and Mangelsdorf, I. (2006) REPDOSE: a database on repeated dose toxicity studies of commercial chemicals - a multifunctional tool. Regul. Toxicol. Pharmacol., 46, 202-210.
-
(2006)
Regul. Toxicol. Pharmacol.
, vol.46
, pp. 202-210
-
-
Bitsch, A.1
Jacobi, S.2
Melber, C.3
Wahnschaffe, U.4
Simetska, N.5
Mangelsdorf, I.6
-
38
-
-
84858976293
-
Inroads to predict in vivo toxicology - an introduction to the eTOX project
-
Briggs, K., Cases, M., Heard, D.J., Pastor, M., Pognan, F., Sanz, F., Schwab, C.F., Steger-Hartmann, T., Sutter, A., Watson, D.K., and Wichard, J.D. (2012) Inroads to predict in vivo toxicology - an introduction to the eTOX project. Int. J. Mol., 13, 3820-3846.
-
(2012)
Int. J. Mol.
, vol.13
, pp. 3820-3846
-
-
Briggs, K.1
Cases, M.2
Heard, D.J.3
Pastor, M.4
Pognan, F.5
Sanz, F.6
Schwab, C.F.7
Steger-Hartmann, T.8
Sutter, A.9
Watson, D.K.10
Wichard, J.D.11
-
39
-
-
84926397335
-
-
Available at, last accessed June 20
-
Clinical Data Interchange Standards Consortium. Available at www.cdisc.org/(last accessed June 20, 2014).
-
(2014)
-
-
-
40
-
-
84871217523
-
Development of an evaluation support system for estimating repeated-dose toxicity of chemicals based on chemical structure
-
(ed. A.G.E. Wilson), RSC Publishing, Cambridge
-
Hayashi, M. and Sakuratani, Y. (2012) Development of an evaluation support system for estimating repeated-dose toxicity of chemicals based on chemical structure, in New Horizons in Predictive Toxicology: Current Status and Application (ed. A.G.E. Wilson), RSC Publishing, Cambridge, pp. 26-37.
-
(2012)
New Horizons in Predictive Toxicology: Current Status and Application
, pp. 26-37
-
-
Hayashi, M.1
Sakuratani, Y.2
-
41
-
-
84862299668
-
Characterization and Application of Physiologically Based Pharmacokinetic Models in Risk Assessment
-
IPCS Harmonization Project Document No. 9
-
World Health Organization (2010) Characterization and Application of Physiologically Based Pharmacokinetic Models in Risk Assessment. IPCS Harmonization Project Document No. 9.
-
(2010)
-
-
-
42
-
-
84873049582
-
Quantitative evaluation and prediction of drug effects and toxicological risk using mechanistic multiscale models
-
Niklas, J., Diaz Ochoa, J.G., Bucher, J., and Mauch, K. (2013) Quantitative evaluation and prediction of drug effects and toxicological risk using mechanistic multiscale models. Mol. Inform., 32, 14-23.
-
(2013)
Mol. Inform.
, vol.32
, pp. 14-23
-
-
Niklas, J.1
Diaz Ochoa, J.G.2
Bucher, J.3
Mauch, K.4
-
43
-
-
35148898451
-
Guidance Document on the Validation of (Quantitative) Structure- Activity Relationship [(Q)SAR] Models
-
OECD Environment Health and Safety Publications, Series on Testing and Assessment, No. 69 (ENV/JM/MONO (2007)2)
-
OECD (2007) Guidance Document on the Validation of (Quantitative) Structure- Activity Relationship [(Q)SAR] Models. OECD Environment Health and Safety Publications, Series on Testing and Assessment, No. 69 (ENV/JM/MONO (2007)2).
-
(2007)
-
-
-
44
-
-
84897530967
-
Developing the applicability domain of in silico models: relevance, importance and methods
-
(eds M.T.D. Cronin and J.C. Madden), RSC Publishing, Cambridge
-
Hewitt, M. and Ellison, C.M. (2010) Developing the applicability domain of in silico models: relevance, importance and methods, in In Silico Toxicology: Principles and Applications (eds M.T.D. Cronin and J.C. Madden), RSC Publishing, Cambridge, pp. 301-333.
-
(2010)
In Silico Toxicology: Principles and Applications
, pp. 301-333
-
-
Hewitt, M.1
Ellison, C.M.2
|