Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Creation of fundamental rules for a decision support system

Alternatives to Laboratory Animals

Volumn 28, Issue 5, 2000, Pages 665-698

  Gerner, I ^a   Zinke, S ^a   Graetschel, G ^a   Schlede, E ^a  

^a Fed Inst Hlth Protect Consumers   (Germany)

Author keywords

Alternative methods; Decision support systems; Electronic database; Eye irritation corrosion; Skin irritation corrosion; Structure activity relationships

Indexed keywords

IRRITANT AGENT;

ALGORITHM; CLINICAL PROTOCOL; COMPUTER; CORROSION; DATA BASE; EUROPEAN UNION; EYE IRRITATION; INFORMATION SYSTEM; LIPID SOLUBILITY; MELTING POINT; MOLECULAR WEIGHT; NONHUMAN; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PRESSURE; PRIORITY JOURNAL; RABBIT; REVIEW; SKIN IRRITATION; STRUCTURE ACTIVITY RELATION; SURFACE TENSION; TOXICITY TESTING;

ORYCTOLAGUS CUNICULUS;

EID: 0033739877     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290002800505     Document Type: Review

References (41)

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7. Heterogeneity effects on permeability-partition coefficient relationships in human stratum corneum
8. Relationships between the structure of compounds and their diffusion across membranes
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10. Structure-activity relationships for di- and trialkyl and/or halogen substituted phenols
11. Structure-toxicity relationships for mono alkyl- or halogen substituted anilines
12. Relationships of quantitative structure-activity for normal aliphatic alcohols
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14. Predicted toxicities of aryl alkanols and related compounds
15. Octanol/water partition coefficients and bioconcentration factors of chloronitrobenzenes in rain bow trout (Salmo Gairdneri)
16. Predicting skin permeability
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18. Kohaesionseigenschaften
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25. Discrimination of statistically equivalent variables in quantitative structure-activity relationships
26. Quantitative structure-activity relationships in predicting chemical toxicity: When is the prediction reliable?
27. Skin corrosivity potential of fatty acids: In vitro rat and human skin testing and QSAR studies
28. Quantitative structure-activity relationships (QSAR) for skin corrosivity of organic acids, bases and phenols: Principal components and neural network analysis of extended datasets
29. The relationships between chemical structure and the logarithm of the partition coefficient
30. Aqueous solubility and n-octanol/water partition coefficient correlations
31. Prediction of octanol/water partition coefficients using parameters derived from molecular structures
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