Bone regulates glucose metabolism as an endocrine organ through osteocalcin

International Journal of Endocrinology

Volumn 2015, Issue , 2015, Pages

  Shao, Jin ^a   Wang, Zhi ^a   Yang, Tieyi ^a   Ying, Hui ^a   Zhang, Yan ^a   Liu, Shuyi ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; INSULIN; OSTEOCALCIN; PRODUCT OF RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASE V; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG; VITAMIN K GROUP;

ADIPOCYTE; B LYMPHOCYTE; BONE DEVELOPMENT; CELL PROLIFERATION; CIRCADIAN RHYTHM; ENDOCRINE FUNCTION; ENERGY METABOLISM; GENE ACTIVATION; GLUCOSE METABOLISM; HORMONE ACTION; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; INSULIN RELEASE; INSULIN SENSITIVITY; MUSCULOSKELETAL SYSTEM; NONHUMAN; OCN GENE; OSSIFICATION; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS REGULATION; PROTEIN TARGETING; REVIEW; TESTIS FUNCTION;

EID: 84926389999     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2015/967673     Document Type: Review

References (72)

1. R. Baron and M. Kneissel, "WNT signaling in bone homeostasis and disease: from human mutations to treatments", Nature Medicine, vol. 19, no. 2, pp. 179-192, 2013.
2. S. Khosla, "Minireview: the OPG/RANKL/RANK system", Endocrinology, vol. 142, no. 12, pp. 5050-5055, 2001.
3. M. E. Brunkow, J. C. Gardner, J. Van Ness et al., "Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein", The American Journal of Human Genetics, vol. 68, no. 3, pp. 577-589, 2001.
4. M. Katoh, "Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis", Stem Cell Reviews, vol. 3, no. 1, pp. 30-38, 2007.
5. S. Fukumoto and T. J. Martin, "Bone as an endocrine organ", Trends in Endocrinology and Metabolism, vol. 20, no. 5, pp. 230-236, 2009.
6. P. V. Hauschka, J. B. Lian, D. E. Cole, and C. M. Gundberg, "Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone", Physiological Reviews, vol. 69, no. 3, pp. 990-1047, 1989.
7. P. A. Price, "Gla-containing proteins of bone", Connective Tissue Research, vol. 21, no. 1-4, pp. 51-57, 1989.
8. A. J. Lee, S. Hodges, and R. Eastell, "Measurement of osteocalcin", Annals of Clinical Biochemistry, vol. 37, part 4, pp. 432-446, 2000.
9. N. K. Lee, H. Sowa, E. Hinoi et al., "Endocrine regulation of energy metabolism by the skeleton", Cell, vol. 130, no. 3, pp. 456-469, 2007.
10. K. K. Ivaska, T. A. Hentunen, J. Vääräniemi, H. Ylipahkala, K. Pettersson, and H. K. Väänänen, "Release of intact and fragmented osteocalcin molecules from bone matrix during bone resorption in vitro", The Journal of Biological Chemistry, vol. 279, no. 18, pp. 18361-18369, 2004.
11. I. Kanazawa and T. Sugimoto, "The relationship between bone and glucose/lipid metabolism", Clinical Calcium, vol. 23, no. 2, pp. 181-188, 2013.
12. M. Ferron, E. Hinoi, G. Karsenty, and P. Ducy, "Osteocalcin diferentially regulates β cell and adipocyte gene expression and afects the development of metabolic diseases in wild-type mice", Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 13, pp. 5266-5270, 2008.
13. A. S. Lihn, S. B. Pedersen, and B. Richelsen, "Adiponectin: action, regulation and association to insulin sensitivity", Obesity Reviews, vol. 6, no. 1, pp. 13-21, 2005.
14. G. L. Klein, "Insulin and bone: recent developments", World Journal of Diabetes, vol. 5, no. 1, pp. 14-16, 2014.
15. S. L. Booth, A. Centi, S. R. Smith, and C. Gundberg, "The role of osteocalcin in human glucose metabolism: marker or mediator?" Nature Reviews Endocrinology, vol. 9, no. 1, pp. 43-55, 2013.
16. Y. Yoshikawa, A. Kode, L. Xu et al., "Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism", Journal of Bone and Mineral Research, vol. 26, no. 9, pp. 2012-2025, 2011.
17. A. L. Boskey, S. Gadaleta, C. Gundberg, S. B. Doty, P. Ducy, and G. Karsenty, "Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin", Bone, vol. 23, no. 3, pp. 187-196, 1998.
18. T. Reinehr and C. L. Roth, "A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss", International Journal of Obesity, vol. 34, no. 5, pp. 852-858, 2010.
19. P. Vergnaud, P. Garnero, P. J. Meunier, G. Bréart, K. Kamihagi, and P. D. Delmas, "Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS study", Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 3, pp. 719-724, 1997.
20. F. Oury, G. Sumara, O. Sumara et al., "Endocrine regulation of male fertility by the skeleton", Cell, vol. 144, no. 5, pp. 796-809, 2011.
21. M. Pi, L. Chen, M.-Z. Huang et al., "GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome", PLoS ONE, vol. 3, no. 12, Article ID e3858, 2008.
22. M. Pi and L. D. Quarles, "Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks", Endocrinology, vol. 153, no. 5, pp. 2062-2069, 2012.
23. Y. Miyauchi, Y. Sato, T. Kobayashi et al., "HIF1alpha is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis", Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 41, pp. 16568-16573, 2013.
24. X. Dai, C. Wang, J. Dai et al., "Association of single nucleotide polymorphisms in estrogen receptor alpha gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population", BioMed Research International, vol. 2014, Article ID 151457, 12 pages, 2014.
25. J. Van De Peppel and J. P. T. M. Van Leeuwen, "Vitamin D and gene networks in human osteoblasts", Frontiers in Physiology, vol. 5, article 137, Article ID Article 137, 2014.
26. D. J. Di Girolamo, T. L. Clemens, and S. Kousteni, "The skeleton as an endocrine organ", Nature Reviews Rheumatology, vol. 8, no. 11, pp. 674-683, 2012.
27. Y. Koshihara and K. Hoshi, "Vitamin K2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro", Journal of Bone and Mineral Research, vol. 12, no. 3, pp. 431-438, 1997.
28. V. J. Woeckel, C. Bruedigam, M. Koedam, H. Chiba, B. C. J. Van Der Eerden, and J. P. T. M. Van Leeuwen, "1α, 25-Dihydroxyvitamin D3 and rosiglitazone synergistically enhance osteoblast-mediated mineralization", Gene, vol. 512, no. 2, pp. 438-443, 2013.
29. J. R. Cairns and P. A. Price, "Direct demonstration that the vitamin K-dependent bone Gla protein is incompletely γ-carboxylated in humans", Journal of Bone and Mineral Research, vol. 9, no. 12, pp. 1989-1997, 1994.
30. L. J. Sokoll and J. A. Sadowski, "Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population", American Journal of Clinical Nutrition, vol. 63, no. 4, pp. 566-573, 1996.
31. M. Ferron, J. Wei, T. Yoshizawa et al., "Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism", Cell, vol. 142, no. 2, pp. 296-308, 2010.
32. S. Kousteni, "FoxO1, the transcriptional chief of staf of energy metabolism", Bone, vol. 50, no. 2, pp. 437-443, 2012.
33. R. T. Franceschi, C. Ge, G. Xiao, H. Roca, and D. Jiang, "Transcriptional regulation of osteoblasts", Cells Tissues Organs, vol. 189, no. 1-4, pp. 144-152, 2008.
34. W. Wang, N. Lian, L. Li et al., "Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossifucation by activating Ihh transcription", Development, vol. 136, no. 24, pp. 4143-4153, 2009.
35. M.-T. Rached, A. Kode, B. C. Silva et al., "FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice", Journal of Clinical Investigation, vol. 120, no. 1, pp. 357-368, 2010.
36. M. Delépine, M. Nicolino, T. Barrett, M. Golamaully, G. Mark Lathrop, and C. Julier, "EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome", Nature Genetics, vol. 25, no. 4, pp. 406-409, 2000.
37. H. P. Harding, H. Zeng, Y. Zhang et al., "Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/-mice reveals a role for translational control in secretory cell survival", Molecular Cell, vol. 7, no. 6, pp. 1153-1163, 2001.
38. D. Ron and P. Walter, "Signal integration in the endoplasmic reticulum unfolded protein response", Nature Reviews Molecular Cell Biology, vol. 8, no. 7, pp. 519-529, 2007.
39. T. Yoshizawa, E. Hinoi, Y. J. Dae et al., "The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts", Journal of Clinical Investigation, vol. 119, no. 9, pp. 2807-2817, 2009.
40. A. Kode, I. Mosialou, B. C. Silva et al., "FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis", Journal of Biological Chemistry, vol. 287, no. 12, pp. 8757-8768, 2012.
41. E. Hinoi, N. Gao, D. Y. Jung et al., "The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity", Journal of Cell Biology, vol. 183, no. 7, pp. 1235-1242, 2008.
42. C. M. Gundberg and R. S. Weinstein, "Multiple immunoreactive forms of osteocalcin in uremic serum", Journal of Clinical Investigation, vol. 77, no. 6, pp. 1762-1767, 1986.
43. K. Fulzele, R. C. Riddle, D. J. Di Girolamo et al., "Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition", Cell, vol. 142, no. 2, pp. 309-319, 2010.
44. J. C. Brüning, M. D. Michael, J. N. Winnay et al., "A musclespecific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance", Molecular Cell, vol. 2, no. 5, pp. 559-569, 1998.
45. K. Fulzele, D. J. Di Girolamo, Z. Liu, J. Xu, J. L. Messina, and T. L. Clemens, "Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action", The Journal of Biological Chemistry, vol. 282, no. 35, pp. 25649-25658, 2007.
46. P. Bialek, B. Kern, X. Yang et al., "A twist code determines the onset of osteoblast differentiation", Developmental Cell, vol. 6, no. 3, pp. 423-435, 2004.
47. B. F. Boyce and L. Xing, "Functions of RANKL/RANK/OPG in bone modeling and remodeling", Archives of Biochemistry and Biophysics, vol. 473, no. 2, pp. 139-146, 2008.
48. M. Pérez-Sayáns, J. M. Somoza-Martín, F. Barros-Angueira, J. M. G. Rey, and A. García-García, "RANK/RANKL/OPG role in distraction osteogenesis", Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 109, no. 5, pp. 679-686, 2010.
49. T. Yoshizawa, "Diabetes mellitus and osteoporosis. Insulin signaling and bone/glucose/energy metabolism", Clinical Calcium, vol. 22, no. 9, pp. 1367-1373, 2012.
50. S. Avnet, F. Perut, M. Salerno, L. Sciacca, and N. Baldini, "Insulin receptor isoforms are differently expressed during human osteoblastogenesis", Differentiation, vol. 83, no. 5, pp. 242-248, 2012.
51. T. L. Clemens and G. Karsenty, "The osteoblast: an insulin target cell controlling glucose homeostasis", Journal of Bone and Mineral Research, vol. 26, no. 4, pp. 677-680, 2011.
52. D. J. Walther, J.-U. Peter, S. Bashammakh et al., "Synthesis of serotonin by a second tryptophan hydroxylase isoform", Science, vol. 299, no. 5603, p. 76, 2003.
53. V. K. Yadav, F. Oury, N. Suda et al., "A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure", Cell, vol. 138, no. 5, pp. 976-989, 2009.
54. C. J. Rosen, "Leptin's RIGHT turn to the brain stem", Cell Metabolism, vol. 10, no. 4, pp. 243-244, 2009.
55. W. Cousin, A. Courseaux, A. Ladoux, C. Dani, and P. Peraldi, "Cloning of hOST-PTP: the only example of a protein-tyrosinephosphatase the function of which has been lost between rodent and human", Biochemical and Biophysical Research Communications, vol. 321, no. 1, pp. 259-265, 2004.
56. P. Szulc and P. D. Delmas, "Biochemical markers of bone turnover: potential use in the investigation and management of postmenopausal osteoporosis", Osteoporosis International, vol. 19, no. 12, pp. 1683-1704, 2008.
57. B. Merle and P. D. Delmas, "Normal carboxylation of circulating osteocalcin (bone Gla-protein) in Paget's disease of bone", Bone and Mineral, vol. 11, no. 2, pp. 237-245, 1990.
58. L. J. Sokoll, S. L. Booth, K. W. Davidson, G. E. Dallal, and J. A. Sadowski, "Diurnal variation in total and undercarboxylated osteocalcin: Influence of increased dietary phylloquinone", Calcified Tissue International, vol. 62, no. 5, pp. 447-452, 1998.
59. C. Rosenquist, P. Qvist, N. Bjarnason, and C. Christiansen, "Measurement of a more stable region of osteocalcin in serum by ELISA with two monoclonal antibodies", Clinical Chemistry, vol. 41, no. 10, pp. 1439-1445, 1995.
60. P. Garnero, M. Grimaux, B. Demiaux, C. Preaudat, P. Seguin, and P. D. Delmas, "Measurement of serum osteocalcin with a human-specific two-site immunoradiometric assay", Journal of Bone and Mineral Research, vol. 7, no. 12, pp. 1389-1398, 1992.
61. S. C. Corlett, M. Couch, A. D. Care, and A. R. Sykes, "Measurement of plasma osteocalcin in sheep: assessment of circadian variation, the effects of age and nutritional status and the response to perturbation of the adrenocortical axis", Experimental Physiology, vol. 75, no. 4, pp. 515-527, 1990.
62. J. Nishimura, N. Arai, and J.-I. Tohmatsu, "Measurement of serum undercarboxylated osteocalcin by ECLIA with the "Picolumi ucOC" kit", Clinical calcium, vol. 17, no. 11, pp. 1702-1708, 2007.
63. C. M. Gundberg, S. D. Nieman, S. Abrams, and H. Rosen, "Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin", Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 9, pp. 3258-3266, 1998.
64. M. K. Shea, E. J. Benjamin, J. Dupuis et al., "Genetic and nongenetic correlates of vitamins K and D", European Journal of Clinical Nutrition, vol. 63, no. 4, pp. 458-464, 2009.
65. P. Garnero, "Markers of bone turnover for the prediction of fracture risk", Osteoporosis International, vol. 11, no. 6, pp. S55-S65, 2000.
66. L. R. McCabe, "Understanding the pathology and mechanisms of type I diabetic bone loss", Journal of Cellular Biochemistry, vol. 102, no. 6, pp. 1343-1357, 2007.
67. M. Inaba, Y. Nishizawa, K. Mita et al., "Poor glycemic control impairs the response of biochemical parameters of bone formation and resorption to exogenous 1, 25-dihydroxyvitamin D3 in patients with type 2 diabetes", Osteoporosis International, vol. 9, no. 6, pp. 525-531, 1999.
68. P. Gerdhem, A. Isaksson, K. Åkesson, and K. J. Obrant, "Increased bone density and decreased bone turnover, but no evident alteration of fracture susceptibility in elderly women with diabetes mellitus", Osteoporosis International, vol. 16, no. 12, pp. 1506-1512, 2005.
69. J. M. Kindblom, C. Ohlsson, O. Ljunggren et al., "Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men", Journal of Bone and Mineral Research, vol. 24, no. 5, pp. 785-791, 2009.
70. E. F. Papakitsou, A. N. Margioris, K. E. Dretakis et al., "Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women", Maturitas, vol. 47, no. 3, pp. 185-193, 2004.
71. P. Ravn, G. Cizza, N. H. Bjarnason et al., "Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women", Journal of Bone and Mineral Research, vol. 14, no. 9, pp. 1622-1627, 1999.
72. I. Kanazawa, T. Yamaguchi, M. Yamauchi et al., "Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus", Osteoporosis International, vol. 22, no. 1, pp. 187-194, 2011.