Increased bone density and decreased bone turnover, but no evident alteration of fracture susceptibility in elderly women with diabetes mellitus

Osteoporosis International

Volumn 16, Issue 12, 2005, Pages 1506-1512

  Gerdhem, P ^a   Isaksson, A ^a   Akesson K ^a   Obrant, Karl J ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Areal bone mineral density; Bone mass; Bone turnover; Diabetes mellitus; Dual energy x ray absorptiometry

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; CALCITRIOL; COLLAGEN TYPE 1; CREATININE; DEOXYPYRIDINOLINE; OSTEOCALCIN; PARATHYROID HORMONE; TELOPEPTIDE;

AGE DISTRIBUTION; AGED; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE MASS; BONE MINERAL; BONE TURNOVER; CALCANEUS; COMPARATIVE STUDY; CONTROLLED STUDY; COVARIANCE; CREATININE BLOOD LEVEL; DISEASE MARKER; DUAL ENERGY X RAY ABSORPTIOMETRY; EVALUATION; FEMALE; FEMUR NECK; HIP; HUMAN; LUMBAR SPINE; MEDICAL ASSESSMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; OSTEOLYSIS; PARATHYROID HORMONE BLOOD LEVEL; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CROSS LINKING; PROTEIN URINE LEVEL; SAMPLE SIZE; VITAMIN DEFICIENCY;

AGED; BIOLOGICAL MARKERS; BONE AND BONES; BONE DENSITY; CALCANEUS; CALCIFEDIOL; DENSITOMETRY, X-RAY; DIABETES MELLITUS; DISEASE SUSCEPTIBILITY; FEMALE; FEMUR NECK; FRACTURES, BONE; HIP; HUMANS; LIFE STYLE; LUMBAR VERTEBRAE; PARATHYROID HORMONE; VITAMIN D;

EID: 29044434138     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-005-1877-5     Document Type: Article

References (30)

1. Hampson G, Evans C, Petitt RJ, Evans WD, Woodhead SJ, Peters JR, Ralston SH (1998) Bone mineral density, collagen type 1 alpha 1 genotypes and bone turnover in premenopausal women with diabetes mellitus. Diabetologia 41:1314-1320
2. Munoz-Torres M, Jodar E, Escobar-Jimenez F, Lopez-Ibarra PJ, Luna JD (1996) Bone mineral density measured by dual X-ray absorptiometry in Spanish patients with insulin-dependent diabetes mellitus. Calcif Tissue Int 58:316-319
3. Miazgowski T, Czekalski S (1998) A 2-year follow-up study on bone mineral density and markers of bone turnover in patients with long-standing insulin-dependent diabetes mellitus. Osteoporos Int 8:399-403
4. Jehle PM, Jehle DR, Mohan S, Bohm BO (1998) Serum levels of insulin-like growth factor system components and relationship to bone metabolism in type 1 and type 2 diabetes mellitus patients. J Endocrinol 159:297-306
5. Gallacher SJ, Fenner JA, Fisher BM, Quin JD, Fraser WD, Logue FC, Cowan RA, Boyle IT, MacCuish AC (1993) An evaluation of bone density and turnover in premenopausal women with type 1 diabetes mellitus. Diabet Med 10:129-133
6. Weber G, Beccaria L, de'Angelis M, Mora S, Galli L, Cazzuffi MA, Turba F, Frisone F, Guarneri MP, Chiumello G (1990) Bone mass in young patients with type I diabetes. Bone Miner 8:23-30
7. Krakauer JC, McKenna MJ, Buderer NF, Rao DS, Whitehouse FW, Parfitt AM (1995) Bone loss and bone turnover in diabetes. Diabetes 44:775-782
8. Tuominen JT, Impivaara O, Puukka P, Ronnemaa T (1999) Bone mineral density in patients with type 1 and type 2 diabetes. Diabetes Care 22:1196-1200
9. Forst T, Pfutzner A, Kann P, Schehler B, Lobmann R, Schafer H, Andreas J, Bockisch A, Beyer J (1995) Peripheral osteopenia in adult patients with insulin-dependent diabetes mellitus. Diabet Med 12:874-879
10. Barrett-Connor E, Holbrook TL (1992) Sex differences in osteoporosis in older adults with non-insulin-dependent diabetes mellitus. JAMA 268:3333-3337
11. el Miedany YM, el Gaafary S, el Baddini MA (1999) Osteoporosis in older adults with non-insulin-dependent diabetes mellitus: is it sex related? Clin Exp Rheumatol 17:561-567
12. van Daele PL, Stolk RP, Burger H, Algra D, Grobbee DE, Hofman A, Birkenhager JC, Pols HA (1995) Bone density in non-insulin-dependent diabetes mellitus. The Rotterdam Study. Ann Intern Med 122:409-414
13. Isaia GC, Ardissone P, Di Stefano M, Ferrari D, Martina V, Porta M, Tagliabue M, Molinatti GM (1999) Bone metabolism in type 2 diabetes mellitus. Acta Diabetol 36:35-38
14. Korpelainen R, Korpelainen J, Heikkinen J, Vaananen K, Keinanen-Kiukaanniemi S (2003) Lifestyle factors are associated with osteoporosis in lean women but not in normal and overweight women: a population-based cohort study of 1,222 women. Osteoporos Int 14:34-43
15. Schwartz AV, Sellmeyer DE, Ensrud KE, Cauley JA, Tabor HK, Schreiner PJ, Jamal SA, Black DM, Cummings SR (2001) Older women with diabetes have an increased risk of fracture: a prospective study. J Clin Endocrinol Metab 86:32-38
16. Sosa M, Dominguez M, Navarro MC, Segarra MC, Hernandez D, de Pablos P, Betancor P (1996) Bone mineral metabolism is normal in non-insulin-dependent diabetes mellitus. J Diabetes Complications 10:201-205
17. Cakatay U, Telci A, Kayali R, Akcay T, Sivas A, Aral F (1998) Changes in bone turnover on deoxypyridinoline levels in diabetic patients. Diabetes Res Clin Pract 40:75-79
18. Pedrazzoni M, Ciotti G, Pioli G, Girasole G, Davoli L, Palummeri E, Passeri M (1989) Osteocalcin levels in diabetic subjects. Calcif Tissue Int 45:331-336
19. Cloos C, Wahl P, Hasslacher C, Traber L, Kistner M, Jurkuhn K, Schmidt-Gayk H (1998) Urinary glycosylated, free and total pyridinoline and free and total deoxypyridinoline in diabetes mellitus. Clin Endocrinol (Oxf) 48:317-323
20. Pietschmann P, Schernthaner G, Woloszczuk W (1988) Serum osteocalcin levels in diabetes mellitus: analysis of the type of diabetes and microvascular complications. Diabetologia 31:892-895
21. Aksoy H, Akcay F, Kurtul N, Baykal O, Avci B (2000) Serum 1,25 dihydroxy vitamin D (1,25(OH)2D3), 25 hydroxy vitamin D (25(OH)D) and parathormone levels in diabetic retinopathy. Clin Biochem 33:47-51
22. Ishida H, Suzuki K, Someya Y, Nishimura M, Sugimoto C, Goto M, Taguchi Y, Kasahara H, Kadowaki S, Imura H et al (1993) Possible compensatory role of parathyroid hormone-related peptide on maintenance of calcium homeostasis in patients with non-insulin-dependent diabetes mellitus. Acta Endocrinol (Copenh) 129:519-524
23. Thomas MK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS (1998) Hypovitaminosis D in medical inpatients. N Engl J Med 338:777-783
24. Ottenbacher KJ, Ostir GV, Peek MK, Goodwin JS, Markides KS (2002) Diabetes mellitus as a risk factor for hip fracture in Mexican-American older adults. J Gerontol A Biol Sci Med Sci 57:M648-653
25. Forsen L, Meyer HE, Midthjell K, Edna TH (1999) Diabetes mellitus and the incidence of hip fracture: results from the Nord-Trondelag Health Survey. Diabetologia 42:920-925
26. Kelsey JL, Browner WS, Seeley DG, Nevitt MC, Cummings SR (1992) Risk factors for fractures of the distal forearm and proximal humerus. The Study of Osteoporotic Fractures Research Group. Am J Epidemiol 135:477-489
27. Reid IR (2002) Relationships among body mass, its components, and bone. Bone 31:547-555
28. Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J, Yanovski JA (2004) The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 89:1196-1199
29. Nicodemus KK, Folsom AR (2001) Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women. Diabetes Care 24:1192-1197
30. Jonsson B (1993) Life style and fracture risk. Thesis. Department of Orthopaedics, Malmö University Hospital, Lund University, Malmö, Sweden