Mutation in MRPS34 Compromises Protein Synthesis and Causes Mitochondrial Dysfunction

PLoS Genetics

Volumn 11, Issue 3, 2015, Pages

  Richman, Tara R ^a   Ermer, Judith A ^a   Davies, Stefan M K ^a   Perks, Kara L ^a   Viola, Helena M ^a,b   Shearwood, Anne Marie J ^a   Hool, Livia C ^a,b   Rackham, Oliver ^a   Filipovska, Aleksandra ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL RIBOSOMAL PROTEIN OF THE SMALL SUBUNIT 34; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RNA 12S; SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; MITOCHONDRIAL DNA; MRPS34 PROTEIN, HUMAN; MRPS34 PROTEIN, MOUSE; RIBOSOME PROTEIN; RIBOSOME RNA; RNA, RIBOSOMAL, 12S;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY METABOLISM; ENZYME ACTIVITY; FATTY LIVER; GENE; GENE MUTATION; HEART HYPERTROPHY; MALE; MITOCHONDRIAL RESPIRATION; MOLECULAR PATHOLOGY; MOUSE; MRPS34 GENE; NONHUMAN; OXYGEN CONSUMPTION; POINT MUTATION; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RNA METABOLISM; ANIMAL; BIOSYNTHESIS; CONGENITAL HEART MALFORMATION; GENETICS; HUMAN; LIVER DISEASE; METABOLISM; MITOCHONDRIAL RIBOSOME; MITOCHONDRION; MUTATION; PATHOLOGY; SACCHAROMYCES CEREVISIAE;

BACTERIA (MICROORGANISMS); CHORDATA; MUS;

ANIMALS; DNA, MITOCHONDRIAL; ENERGY METABOLISM; HEART DEFECTS, CONGENITAL; HUMANS; LIVER DISEASES; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MITOCHONDRIAL RIBOSOMES; MUTATION; RIBOSOMAL PROTEINS; RNA, RIBOSOMAL; SACCHAROMYCES CEREVISIAE;

EID: 84926377210     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005089     Document Type: Article

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