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Volumn 35, Issue 4, 2015, Pages 1623-1632

TGF-β regulates hepatocellular carcinoma progression by inducing treg cell polarization

Author keywords

HCC; TGF ; Treg cells

Indexed keywords

DIETHYLNITROSAMINE; INTERLEUKIN 10; RECEPTOR BLOCKING AGENT; SM 16; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG; AZABICYCLO DERIVATIVE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GP73 PROTEIN, MOUSE; MEMBRANE PROTEIN; PHOSPHOPROTEIN; SM16 COMPOUND;

EID: 84926362945     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000373976     Document Type: Article
Times cited : (101)

References (38)
  • 2
    • 33748114343 scopus 로고    scopus 로고
    • The contributions of hepatitis b virus and hepatitis c virus infections to cirrhosis and primary liver cancer worldwide
    • Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP: The contributions of hepatitis b virus and hepatitis c virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 2006;45:529-538.
    • (2006) J Hepatol , vol.45 , pp. 529-538
    • Perz, J.F.1    Armstrong, G.L.2    Farrington, L.A.3    Hutin, Y.J.4    Bell, B.P.5
  • 4
    • 84866875666 scopus 로고    scopus 로고
    • Genomic landscape of liver cancer
    • Zhang Z: Genomic landscape of liver cancer. Nat Genet 2012;44:1075-1077.
    • (2012) Nat Genet , vol.44 , pp. 1075-1077
    • Zhang, Z.1
  • 5
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M: Immunity, inflammation, and cancer. Cell 2010;140:883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 6
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: The cancer-immunity cycle
    • Chen DS, Mellman I: Oncology meets immunology: the cancer-immunity cycle. Immunity 2013;39:1-10.
    • (2013) Immunity , vol.39 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 7
    • 45749137283 scopus 로고    scopus 로고
    • High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma
    • Zhu XD, Zhang JB, Zhuang PY, Zhu HG, Zhang W, Xiong YQ, Wu WZ, Wang L, Tang ZY, Sun HC: High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J Clin Oncol 2008;26:2707-2716.
    • (2008) J Clin Oncol , vol.26 , pp. 2707-2716
    • Zhu, X.D.1    Zhang, J.B.2    Zhuang, P.Y.3    Zhu, H.G.4    Zhang, W.5    Xiong, Y.Q.6    Wu, W.Z.7    Wang, L.8    Tang, Z.Y.9    Sun, H.C.10
  • 8
    • 77952426237 scopus 로고    scopus 로고
    • Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice
    • Gao Y, Yao A, Zhang W, Lu S, Yu Y, Deng L, Yin A, Xia Y, Sun B, Wang X: Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice. Oncogene 2010;29:2784-2794.
    • (2010) Oncogene , vol.29 , pp. 2784-2794
    • Gao, Y.1    Yao, A.2    Zhang, W.3    Lu, S.4    Yu, Y.5    Deng, L.6    Yin, A.7    Xia, Y.8    Sun, B.9    Wang, X.10
  • 9
    • 64549108462 scopus 로고    scopus 로고
    • Increased intratumoral il-17-producing cells correlate with poor survival in hepatocellular carcinoma patients
    • Zhang JP, Yan J, Xu J, Pang XH, Chen MS, Li L, Wu C, Li SP, Zheng L: Increased intratumoral il-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol 2009;50:980-989.
    • (2009) J Hepatol , vol.50 , pp. 980-989
    • Zhang, J.P.1    Yan, J.2    Xu, J.3    Pang, X.H.4    Chen, M.S.5    Li, L.6    Wu, C.7    Li, S.P.8    Zheng, L.9
  • 10
    • 79951677462 scopus 로고    scopus 로고
    • Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection
    • Li YW, Qiu SJ, Fan J, Zhou J, Gao Q, Xiao YS, Xu YF: Intratumoral neutrophils: a poor prognostic factor for hepatocellular carcinoma following resection. J Hepatol 2011;54:497-505.
    • (2011) J Hepatol , vol.54 , pp. 497-505
    • Li, Y.W.1    Qiu, S.J.2    Fan, J.3    Zhou, J.4    Gao, Q.5    Xiao, Y.S.6    Xu, Y.F.7
  • 11
    • 65549115862 scopus 로고    scopus 로고
    • Plasticity of cd4+ t cell lineage differentiation
    • Zhou L, Chong MM, Littman DR: Plasticity of cd4+ t cell lineage differentiation. Immunity 2009;30:646-655.
    • (2009) Immunity , vol.30 , pp. 646-655
    • Zhou, L.1    Chong, M.M.2    Littman, D.R.3
  • 13
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory t cells and immune tolerance
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M: Regulatory t cells and immune tolerance. Cell 2008;133:775-787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 16
    • 1642497640 scopus 로고    scopus 로고
    • Tumor-specific human cd4+ regulatory t cells and their ligands: Implications for immunotherapy
    • Wang HY, Lee DA, Peng G, Guo Z, Li Y, Kiniwa Y, Shevach EM, Wang RF: Tumor-specific human cd4+ regulatory t cells and their ligands: implications for immunotherapy. Immunity 2004;20:107-118.
    • (2004) Immunity , vol.20 , pp. 107-118
    • Wang, H.Y.1    Lee, D.A.2    Peng, G.3    Guo, Z.4    Li, Y.5    Kiniwa, Y.6    Shevach, E.M.7    Wang, R.F.8
  • 17
    • 0036372440 scopus 로고    scopus 로고
    • Transforming growth factor-beta in t-cell biology
    • Gorelik L, Flavell RA: Transforming growth factor-beta in t-cell biology. Nat Rev Immunol 2002;2:46-53.
    • (2002) Nat Rev Immunol , vol.2 , pp. 46-53
    • Gorelik, L.1    Flavell, R.A.2
  • 18
    • 0036358166 scopus 로고    scopus 로고
    • Tgf-beta: Receptors, signaling pathways and autoimmunity
    • Chen W, Wahl SM: Tgf-beta: receptors, signaling pathways and autoimmunity. Curr Dir Autoimmun 2002;5:62-91.
    • (2002) Curr Dir Autoimmun , vol.5 , pp. 62-91
    • Chen, W.1    Wahl, S.M.2
  • 19
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral cd4+cd25-naive t cells to cd4+cd25+ regulatory t cells by tgf-beta induction of transcription factor foxp3
    • Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM: Conversion of peripheral cd4+cd25-naive t cells to cd4+cd25+ regulatory t cells by tgf-beta induction of transcription factor foxp3. J Exp Med 2003;198:1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 20
    • 0035876913 scopus 로고    scopus 로고
    • A role for tgf-beta in the generation and expansion of cd4+cd25+ regulatory t cells from human peripheral blood
    • Yamagiwa S, Gray JD, Hashimoto S, Horwitz DA: A role for tgf-beta in the generation and expansion of cd4+cd25+ regulatory t cells from human peripheral blood. J Immunol 2001;166:7282-7289.
    • (2001) J Immunol , vol.166 , pp. 7282-7289
    • Yamagiwa, S.1    Gray, J.D.2    Hashimoto, S.3    Horwitz, D.A.4
  • 26
    • 84888639681 scopus 로고    scopus 로고
    • The roles of tgfbeta in the tumour microenvironment
    • Pickup M, Novitskiy S, Moses HL: The roles of tgfbeta in the tumour microenvironment. Nat Rev Cancer 2013;13:788-799.
    • (2013) Nat Rev Cancer , vol.13 , pp. 788-799
    • Pickup, M.1    Novitskiy, S.2    Moses, H.L.3
  • 29
    • 79951677462 scopus 로고    scopus 로고
    • Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection
    • Li YW, Qiu SJ, Fan J, Zhou J, Gao Q, Xiao YS, Xu YF: Intratumoral neutrophils: a poor prognostic factor for hepatocellular carcinoma following resection. J Hepatol 2011;54:497-505.
    • (2011) J Hepatol , vol.54 , pp. 497-505
    • Li, Y.W.1    Qiu, S.J.2    Fan, J.3    Zhou, J.4    Gao, Q.5    Xiao, Y.S.6    Xu, Y.F.7
  • 30
    • 64549108462 scopus 로고    scopus 로고
    • Increased intratumoral il-17-producing cells correlate with poor survival in hepatocellular carcinoma patients
    • Zhang JP, Yan J, Xu J, Pang XH, Chen MS, Li L, Wu C, Li SP, Zheng L: Increased intratumoral il-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol 2009;50:980-989.
    • (2009) J Hepatol , vol.50 , pp. 980-989
    • Zhang, J.P.1    Yan, J.2    Xu, J.3    Pang, X.H.4    Chen, M.S.5    Li, L.6    Wu, C.7    Li, S.P.8    Zheng, L.9
  • 31
    • 84879499912 scopus 로고    scopus 로고
    • Tgf-beta1 secreted by hepatocellular carcinoma induces the expression of the foxp3 gene and suppresses antitumor immunity in the tumor microenvironment
    • Wang Y, Deng B, Tang W, Liu T, Shen X: Tgf-beta1 secreted by hepatocellular carcinoma induces the expression of the foxp3 gene and suppresses antitumor immunity in the tumor microenvironment. Dig Dis Sci 2013;58:1644-1652.
    • (2013) Dig Dis Sci , vol.58 , pp. 1644-1652
    • Wang, Y.1    Deng, B.2    Tang, W.3    Liu, T.4    Shen, X.5
  • 32
    • 70350059078 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor beta receptor i kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation
    • Mazzocca A, Fransvea E, Lavezzari G, Antonaci S, Giannelli G: Inhibition of transforming growth factor beta receptor i kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation. Hepatology 2009;50:1140-1151.
    • (2009) Hepatology , vol.50 , pp. 1140-1151
    • Mazzocca, A.1    Fransvea, E.2    Lavezzari, G.3    Antonaci, S.4    Giannelli, G.5
  • 33
    • 63349088695 scopus 로고    scopus 로고
    • Targeting transforming growth factor (tgf)-betari inhibits activation of beta1 integrin and blocks vascular invasion in hepatocellular carcinoma
    • Fransvea E, Mazzocca A, Antonaci S, Giannelli G: Targeting transforming growth factor (tgf)-betari inhibits activation of beta1 integrin and blocks vascular invasion in hepatocellular carcinoma. Hepatology 2009;49:839-850.
    • (2009) Hepatology , vol.49 , pp. 839-850
    • Fransvea, E.1    Mazzocca, A.2    Antonaci, S.3    Giannelli, G.4
  • 35
    • 52649167708 scopus 로고    scopus 로고
    • Cd4 t cells: Fates, functions, and faults
    • Zhu J, Paul WE: Cd4 t cells: fates, functions, and faults. Blood 2008;112:1557-1569.
    • (2008) Blood , vol.112 , pp. 1557-1569
    • Zhu, J.1    Paul, W.E.2
  • 36
    • 72249119029 scopus 로고    scopus 로고
    • Serum levels of interleukin-10 and interleukin-12 predict early, spontaneous hepatitis b virus e antigen seroconversion
    • Wu JF, Wu TC, Chen CH, Ni YH, Chen HL, Hsu HY, Chang MH: Serum levels of interleukin-10 and interleukin-12 predict early, spontaneous hepatitis b virus e antigen seroconversion. Gastroenterology 2010;138:165-172.
    • (2010) Gastroenterology , vol.138 , pp. 165-172
    • Wu, J.F.1    Wu, T.C.2    Chen, C.H.3    Ni, Y.H.4    Chen, H.L.5    Hsu, H.Y.6    Chang, M.H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.