Serum Levels of Interleukin-10 and Interleukin-12 Predict Early, Spontaneous Hepatitis B Virus e Antigen Seroconversion

Gastroenterology

Volumn 138, Issue 1, 2010, Pages

  Wu, Jia Feng ^a   Wu, Tzee Chung ^b   Chen, Chien Hung ^a   Ni, Yen Hsuan ^a   Chen, Huey Ling ^a   Hsu, Hong Yuan ^a   Chang, Mei Hwei ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; HEPATITIS B CORE ANTIGEN; HEPATITIS B(E) ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 2; INTERLEUKIN 4;

ADOLESCENT; ARTICLE; BLOOD LEVEL; CHRONIC DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; GENOTYPE; HEPATITIS B; HUMAN; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; SEROCONVERSION; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL;

EID: 72249119029     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.09.018     Document Type: Article

References (28)

1. Beasley R.P., Hwang L.Y., Lin C.C., et al. Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22,707 men in Taiwan. Lancet 2 (1981) 1129-1133
2. Liu Z., Luo K., He H., et al. Hot-spot mutations in hepatitis B virus core gene: eliciting or evading immune clearance?. J Viral Hepatol 12 (2005) 146-153
3. Fattovich G., Rugge M., Brollo L., et al. Clinical, virologic, and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B. Hepatology 6 (1986) 167-172
4. Yang H.I., Lu S.N., Liaw Y.F., et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 347 (2002) 168-174
5. Beasley R.P., Trepo C., Stevens C.E., et al. The e antigen and vertical transmission of hepatitis B surface antigen. Am J Epidemiol 105 (1977) 94-98
6. Hsu S.C., Chang M.H., Ni Y.H., et al. Horizontal transmission of hepatitis B virus in children. J Pediatr Gastroenterol Nutr 16 (1993) 66-69
7. Hsu H.Y., Chang M.H., Chen D.S., et al. Baseline seroepidemiology of hepatitis B virus infection in children in Taipei, 1984: a study just before mass hepatitis B vaccination program in Taiwan. J Med Virol 18 (1986) 301-307
8. Chang M.H., Sung J.L., Lee C.Y., et al. Factors affecting clearance of hepatitis B e antigen in hepatitis B surface antigen carrier children. J Pediatr 115 (1989) 385-390
9. Koziel M.J. Cytokines in viral hepatitis. Semin Liver Dis 19 (1999) 157-169
10. Takakura M., Tokushige K., Matsushita N., et al. Possible involvement of cytokine gene polymorphisms in fulminant hepatitis. J Gastroenterol Hepatol 22 (2007) 1271-1277
11. Bidwell J., Keen L., Gallagher G., et al. Cytokine gene polymorphism in human disease: on-line database. Genes Immun 1 (1999) 3-19
12. Tseng L.H., Lin M.T., Shau W.Y., et al. Correlation of interleukine-10 gene haplotype with hepatocellular carcinoma in Taiwan. Tissue Antigens 67 (2006) 127-133
13. Migita K., Miyazoe S., Maeda Y., et al. Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection-association between TGF-β1 polymorphisms and hepatocellular carcinoma. J Hepatol 42 (2005) 505-510
14. Cheong J.Y., Cho S.W., Hwang I.L., et al. Association between chronic hepatitis B virus infection and interleukin-10, tumor necrosis factor-α gene promoter polymorphisms. J Gastroenterol Hepatol 21 (2006) 1163-1169
15. Wang I.J., Chiang T.H., Shih Y.F., et al. The association of single nucleotide polymorphisms in the MMP-9 genes with susceptibility to acute primary angle closure glaucoma in Taiwanese patients. Mol Vis 12 (2006) 1223-1232
16. Yeh S.H., Tsai C.Y., Kao J.H., et al. Quantification and genotyping of hepatitis B virus in a single reaction by real-time PCR and melting curve analysis. J Hepatol 41 (2004) 659-666
17. Miyazoe S., Hamasaki K., Nakata K., et al. Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus. Am J Gastroenterol 97 (2002) 2086-2092
18. Thursz M. Genetic susceptibility in chronic viral hepatitis. Antiviral Res 52 (2001) 113-116
19. Lin T.M., Chen C.J., Wu M.M., et al. Hepatitis B virus markers in Chinese twins. Anticancer Res 9 (1989) 737-742
20. Bozkaya H., Bozdayi M., Turkyilmaz R., et al. Circulating IL-2, IL-10 and TNF- in chronic hepatitis B: their relations to HBeAg status and the activity of liver disease. Hepatogastroenterology 47 (2000) 1675-1679
21. Ni Y.H., Chang M.H., Wang K.J., et al. Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma. Gastroenterology 123 (2002) 1848-1856
22. Liu C.J., Kao J.H., and Chen D.S. Therapeutic implications of hepatitis B virus genotypes. Liver Int 25 (2005) 1097-1107
23. Turner D.M., Williams D.M., Sankaran D., et al. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 24 (1997) 1-8
24. Miyazoe S., Hamasaki K., Nakata K., et al. Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus. Am J Gastroenterol 97 (2002) 2086-2092
25. Santin A.D., Hermonat P.L., Ravaggi A., et al. Interleukin-10 increases Th1 cytokine production and cytotoxic potential in human papilloma-virus-specific CD8+ cytotoxic T lymphocytes. J Virol 74 (2000) 4729-4737
26. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13 (1995) 251-276
27. Rigopoulou E.I., Suri D., Chokshi S., et al. Lamivudine plus interleukin-12 combination therapy in chronic hepatitis B, antiviral and immunological activity. Hepatology 42 (2005) 1028-1036
28. Rossol S., Marinos G., Carucci P., et al. Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. J Clin Invest 99 (1997) 3025-3033