Paroxetine alleviates rat limb post-ischemia induced allodynia through GRK2 upregulation in superior cervical ganglia

International Journal of Clinical and Experimental Medicine

Volumn 8, Issue 2, 2015, Pages 2065-2076

  Tang, Jun ^a   Dong, Jing ^b   Yang, Li ^a   Gao, Lingqi ^b   Zheng, Jijian ^b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

Author keywords

Complex regional pain syndrome type I; G protein coupled receptor kinase 2; Mechanical and cold allodynia; Paroxetine; Selective serotonin reuptake inhibitor; Superior cervical ganglion neurons

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE 2; MESSENGER RNA; PAROXETINE; SEROTONIN UPTAKE INHIBITOR;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RESPONSE; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SUPERIOR CERVICAL GANGLION; UPREGULATION;

RATTUS;

EID: 84926356681     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Schlereth T, Drummond PD and Birklein F. Inflammation in CRPS: role of the sympathetic supply. Auton Neurosci 2014; 182: 102-107.
2. Beerthuizen A, Stronks DL, Van’t Spijker A, Yaksh A, Hanraets BM, Klein J and Huygen FJ. Demographic and medical parameters in the development of complex regional pain syndrome type 1 (CRPS1): prospective study on 596 patients with a fracture. Pain 2012; 153: 1187-1192.
3. Borchers AT and Gershwin ME. Complex regional pain syndrome: a comprehensive and critical review. Autoimmun Rev 2014; 13: 242-265.
4. Gierthmuhlen J, Binder A and Baron R. Mechanism-based treatment in complex regional pain syndromes. Nat Rev Neurol 2014; 10: 518-528.
5. Harden RN, Bruehl S, Stanton-Hicks M and Wilson PR. Proposed new diagnostic criteria for complex regional pain syndrome. Pain Med 2007; 8: 326-331.
6. Harden RN, Oaklander AL, Burton AW, Perez RS, Richardson K, Swan M, Barthel J, Costa B, Graciosa JR, Bruehl S and Reflex Sympathetic Dystrophy Syndrome A. Complex regional pain syndrome: practical diagnostic and treatment guidelines, 4th edition. Pain Med 2013; 14: 180-229.
7. Sindrup SH, Otto M, Finnerup NB and Jensen TS. Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol 2005; 96: 399-409.
8. Lynch ME. Antidepressants as analgesics: a review of randomized controlled trials. J Psychiatry Neurosci 2001; 26: 30-36.
9. Zarei M, Sabetkasaei M and Moini Zanjani T. Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain. Iran Biomed J 2014; 18: 94-100.
10. Tomkins GE, Jackson JL, O’Malley PG, Balden E and Santoro JE. Treatment of chronic headache with antidepressants: a meta-analysis. Am J Med 2001; 111: 54-63.
11. Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B and Dubner R. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 1992; 326: 1250-1256.
12. Dharmshaktu P, Tayal V and Kalra BS. Efficacy of antidepressants as analgesics: a review. J Clin Pharmacol 2012; 52: 6-17.
13. Jackson KC II. Pharmacotherapy for neuropathic pain. Pain Pract 2006; 6: 27-33.
14. Sindrup SH, Gram LF, Brosen K, Eshoj O and Mogensen EF. The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain 1990; 42: 135-144.
15. Ikeda T, Ishida Y, Naono R, Takeda R, Abe H, Nakamura T and Nishimori T. Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain. Neurosci Res 2009; 63: 42-46.
16. Eijkelkamp N, Heijnen CJ, Willemen HL, Deumens R, Joosten EA, Kleibeuker W, den Hartog IJ, van Velthoven CT, Nijboer C, Nassar MA, Dorn GW II, Wood JN and Kavelaars A. GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain. J Neurosci 2010; 30: 2138-2149.
17. Eijkelkamp N, Wang H, Garza-Carbajal A, Willemen HL, Zwartkruis FJ, Wood JN, Dantzer R, Kelley KW, Heijnen CJ and Kavelaars A. Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK. J Neurosci 2010; 30: 12806-12815.
18. Willemen HL, Eijkelkamp N, Wang H, Dantzer R, Dorn GW II, Kelley KW, Heijnen CJ and Kavelaars A. Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling. Pain 2010; 150: 550-560.
19. Mico JA, Ardid D, Berrocoso E and Eschalier A. Antidepressants and pain. Trends Pharmacol Sci 2006; 27: 348-354.
20. Sawynok J, Esser MJ and Reid AR. Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J Psychiatry Neurosci 2001; 26: 21-29.
21. Coderre TJ, Xanthos DN, Francis L and Bennett GJ. Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain 2004; 112: 94-105.
22. Kauppila T. Cold exposure enhances tactile allodynia transiently in mononeuropathic rats. Exp Neurol 2000; 161: 740-744.
23. Chaplan SR, Bach FW, Pogrel JW, Chung JM and Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53: 55-63.
24. Dixon WJ. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 1980; 20: 441-462.
25. Millecamps M and Coderre TJ. Rats with chronic post-ischemia pain exhibit an analgesic sensitivity profile similar to human patients with complex regional pain syndrome--type I. Eur J Pharmacol 2008; 583: 97-102.
26. Flatters SJ and Bennett GJ. Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain 2004; 109: 150-161.
27. Guo TZ, Wei T and Kingery WS. Glucocorticoid inhibition of vascular abnormalities in a tibia fracture rat model of complex regional pain syndrome type I. Pain 2006; 121: 158-167.
28. Naleschinski D and Baron R. Complex regional pain syndrome type I: neuropathic or not? Curr Pain Headache Rep 2010; 14: 196-202.
29. Ferrari LF, Bogen O, Alessandri-Haber N, Levine E, Gear RW and Levine JD. Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain. Neuroscience 2012; 222: 392-403.
30. Kavelaars A, Eijkelkamp N, Willemen HL, Wang H, Carbajal AG and Heijnen CJ. Microglial GRK2: a novel regulator of transition from acute to chronic pain. Brain Behav Immun 2011; 25: 1055-1060.
31. Lombardi MS, Kavelaars A, Schedlowski M, Bijlsma JW, Okihara KL, Van de Pol M, Ochsmann S, Pawlak C, Schmidt RE and Heijnen CJ. Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. FASEB J 1999; 13: 715-725.
32. Vroon A, Kavelaars A, Limmroth V, Lombardi MS, Goebel MU, Van Dam AM, Caron MG, Schedlowski M and Heijnen CJ. G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis. J Immunol 2005; 174: 4400-4406.
33. Kawano T, Soga T, Chi H, Eguchi S, Yamazaki F and Yokoyama M. The involvement of the neurosteroid allopregnanolone in the antihyperalgesic effect of paroxetine in a rat model of neuropathic pain. Neuroreport 2011; 22: 984-988.
34. Grange-Midroit M, Garcia-Sevilla JA, Ferrer-Alcon M, La Harpe R, Huguelet P and Guimon J. Regulation of GRK 2 and 6, beta-arrestin-2 and associated proteins in the prefrontal cortex of drug-free and antidepressant drug-treated subjects with major depression. Brain Res Mol Brain Res 2003; 111: 31-41.
35. Matuzany-Ruban A, Golan M, Miroshnik N, Schreiber G and Avissar S. Normalization of GRK2 protein and mRNA measures in patients with depression predict response to antidepressants. Int J Neuropsychopharmacol 2010; 13: 83-91.
36. Shir Y and Seltzer Z. A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats. Neurosci Lett 1990; 115: 62-67.
37. Kinnman E and Levine JD. Sensory and sympathetic contributions to nerve injury-induced sensory abnormalities in the rat. Neuroscience 1995; 64: 751-767.
38. Sasaki A, Inomata Y, Serizawa K, Andoh T and Kuraishi Y. Contribution of sensory C-fiber neuron injury to mechanical dynamic allodynia in a murine model of postherpetic neuralgia. Neuroreport 2013; 24: 137-141.
39. Buck SH and Burks TF. The neuropharmacology of capsaicin: review of some recent observations. Pharmacol Rev 1986; 38: 179-226.
40. Neil A, Attal N and Guilbaud G. Effects of guanethidine on sensitization to natural stimuli and self-mutilating behaviour in rats with a peripheral neuropathy. Brain Res 1991; 565: 237-246.
41. Shir Y and Seltzer Z. Effects of sympathectomy in a model of causalgiform pain produced by partial sciatic nerve injury in rats. Pain 1991; 45: 309-320.
42. Watari K, Nakaya M and Kurose H. Multiple functions of G protein-coupled receptor kinases. J Mol Signal 2014; 9: 1.
43. Thal DM, Homan KT, Chen J, Wu EK, Hinkle PM, Huang ZM, Chuprun JK, Song J, Gao E, Cheung JY, Sklar LA, Koch WJ and Tesmer JJ. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem Biol 2012; 7: 1830-1839.
44. Ribeiro FM, Ferreira LT, Paquet M, Cregan T, Ding Q, Gros R and Ferguson SS. Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons. J Biol Chem 2009; 284: 23444-23453.
45. Dale LB, Bhattacharya M, Seachrist JL, Anborgh PH and Ferguson SS. Agonist-stimulated and tonic internalization of metabotropic glutamate receptor 1a in human embryonic kidney 293 cells: agonist-stimulated endocytosis is beta-arrestin1 isoform-specific. Mol Pharmacol 2001; 60: 1243-1253.
46. Dhami GK, Anborgh PH, Dale LB, Sterne-Marr R and Ferguson SS. Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G protein-coupled receptor kinase 2. J Biol Chem 2002; 277: 25266-25272.
47. Perroy J, Adam L, Qanbar R, Chenier S and Bouvier M. Phosphorylation-independent desensitization of GABA(B) receptor by GRK4. EMBO J 2003; 22: 3816-3824.