Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption

Lipids in Health and Disease

Volumn 12, Issue 1, 2013, Pages

  Meller, Nahum ^a   Morgan, Michelle E ^a   Wong, Winifred Ps ^a   Altemus, Jessica B ^a   Sehayek, Ephraim ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Acsl5; Acyl CoA; Fat absorption; Fatp4; LCFA; Small intestine

Indexed keywords

FATTY ACID; FATTY ACID TRANSPORTER 4; LONG CHAIN FATTY ACID COENZYME A LIGASE; LONG CHAIN FATTY ACID COENZYME A LIGASE 5; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HIGH THROUGHPUT SEQUENCING; JEJUNUM MUCOSA; LIPID ABSORPTION; LIPID DIET; LIPOGENESIS; MALE; MOUSE; NONHUMAN; RNA SEQUENCE; SMALL INTESTINE ABSORPTION; WEIGHT GAIN;

ABSORPTION; ANIMALS; COENZYME A; COENZYME A LIGASES; DIET; FATTY ACID TRANSPORT PROTEINS; FATTY ACIDS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; JEJUNUM; MICE; MICE, KNOCKOUT;

MUS;

EID: 84878895840     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-12-88     Document Type: Article

References (7)

1. The mechanism of the formation and secretion of chylomicrons. Kindel T, Lee DM, Tso P, Atheroscler Suppl 2010 11 11 16 20493784
2. Intestinal lipid absorption. Iqbal J, Hussain MM, Am J Physiol Endocrinol Metab 2009 296 1183 E1194 10.1152/ajpendo.90899.2008 19158321
3. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, Maiguel D, Jia Z, Pevsner J, J Lipid Res 2007 48 2736 2750 10.1194/jlr.M700378-JLR200 17762044 (Pubitemid 350272858)
4. Peroxisomal acyl-CoA synthetases. Watkins PA, Ellis JM, Biochim Biophys Acta 1822 2012 1411 1420
5. Long-chain acyl-CoA synthetases and fatty acid channeling. Mashek DG, Li LO, Coleman RA, Future Lipidol 2007 2 465 476 10.2217/17460875.2.4.465 20354580 (Pubitemid 47260284)
6. Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice. Shim J, Moulson CL, Newberry EP, Lin MH, Xie Y, Kennedy SM, Miner JH, Davidson NO, J Lipid Res 2009 50 491 500 18843142
7. Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. Hall AM, Wiczer BM, Herrmann T, Stremmel W, Bernlohr DA, J Biol Chem 2005 280 11948 11954 10.1074/jbc.M412629200 15653672 (Pubitemid 40418511)