메뉴 건너뛰기




Volumn 98, Issue 3, 2015, Pages 419-426

HDAC1 overexpression independently predicts biochemical recurrence and is associated with rapid tumor cell proliferation and genomic instability in prostate cancer

Author keywords

ERG; Genomic deletions; HDAC1; Immunohistochemistry; Prognosis; Prostate cancer; Tissue microarray

Indexed keywords

HISTONE DEACETYLASE 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; HDAC1 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84926341508     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2015.03.024     Document Type: Article
Times cited : (26)

References (53)
  • 1
    • 57349093914 scopus 로고    scopus 로고
    • Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer
    • Bjorkman M., et al. Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer. Int. J. Cancer 2008, 123(12):2774-2781.
    • (2008) Int. J. Cancer , vol.123 , Issue.12 , pp. 2774-2781
    • Bjorkman, M.1
  • 2
    • 84877747485 scopus 로고    scopus 로고
    • CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer
    • Burkhardt L., et al. CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer. Cancer Res. 2013, 73(9):2795-2805.
    • (2013) Cancer Res. , vol.73 , Issue.9 , pp. 2795-2805
    • Burkhardt, L.1
  • 3
    • 0034665124 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo
    • Butler L.M., et al. Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res. 2000, 60(18):5165-5170.
    • (2000) Cancer Res. , vol.60 , Issue.18 , pp. 5165-5170
    • Butler, L.M.1
  • 4
    • 70350109641 scopus 로고    scopus 로고
    • ETS gene fusions in prostate cancer
    • Clark J.P., Cooper C.S. ETS gene fusions in prostate cancer. Nat. Rev. Urol. 2009, 6(8):429-439.
    • (2009) Nat. Rev. Urol. , vol.6 , Issue.8 , pp. 429-439
    • Clark, J.P.1    Cooper, C.S.2
  • 5
    • 84891911658 scopus 로고    scopus 로고
    • Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer
    • Ellis L., et al. Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer. Oncotarget 2013, 4(12):2225-2236.
    • (2013) Oncotarget , vol.4 , Issue.12 , pp. 2225-2236
    • Ellis, L.1
  • 6
    • 84859426392 scopus 로고    scopus 로고
    • Upgrading and downgrading of prostate cancer from biopsy to radical prostatectomy: incidence and predictive factors using the modified Gleason grading system and factoring in tertiary grades
    • Epstein J.I., et al. Upgrading and downgrading of prostate cancer from biopsy to radical prostatectomy: incidence and predictive factors using the modified Gleason grading system and factoring in tertiary grades. Eur. Urol. 2012, 61(5):1019-1024.
    • (2012) Eur. Urol. , vol.61 , Issue.5 , pp. 1019-1024
    • Epstein, J.I.1
  • 7
    • 79956042920 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells
    • Fortson W.S., et al. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. Int. J. Oncol. 2011, 39(1):111-119.
    • (2011) Int. J. Oncol. , vol.39 , Issue.1 , pp. 111-119
    • Fortson, W.S.1
  • 8
    • 34547897023 scopus 로고    scopus 로고
    • Histone deacetylases and cancer
    • Glozak M.A., Seto E. Histone deacetylases and cancer. Oncogene 2007, 26(37):5420-5432.
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5420-5432
    • Glozak, M.A.1    Seto, E.2
  • 9
    • 84886950583 scopus 로고    scopus 로고
    • Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation
    • Gong F., Miller K.M. Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation. Mutat. Res. 2013, 750(1-2):23-30.
    • (2013) Mutat. Res. , vol.750 , Issue.1-2 , pp. 23-30
    • Gong, F.1    Miller, K.M.2
  • 10
    • 84888003158 scopus 로고    scopus 로고
    • High lysophosphatidylcholine acyltransferase 1 expression independently predicts high risk for biochemical recurrence in prostate cancers
    • Grupp K., et al. High lysophosphatidylcholine acyltransferase 1 expression independently predicts high risk for biochemical recurrence in prostate cancers. Mol. Oncol. 2013, 7(6):1001-1011.
    • (2013) Mol. Oncol. , vol.7 , Issue.6 , pp. 1001-1011
    • Grupp, K.1
  • 11
    • 84887955643 scopus 로고    scopus 로고
    • High mitochondria content is associated with prostate cancer disease progression
    • Grupp K., et al. High mitochondria content is associated with prostate cancer disease progression. Mol. Cancer 2013, 12(1):145.
    • (2013) Mol. Cancer , vol.12 , Issue.1 , pp. 145
    • Grupp, K.1
  • 12
    • 84904057750 scopus 로고    scopus 로고
    • The prognostic impact of high Nijmegen breakage syndrome (NBS1) gene expression in ERG negative prostate cancers lacking PTEN deletion is driven by KPNA2 expression
    • (Sep 15)
    • Grupp K., et al. The prognostic impact of high Nijmegen breakage syndrome (NBS1) gene expression in ERG negative prostate cancers lacking PTEN deletion is driven by KPNA2 expression. Int. J. Cancer 2014, 135(6):1399-1407. (Sep 15).
    • (2014) Int. J. Cancer , vol.135 , Issue.6 , pp. 1399-1407
    • Grupp, K.1
  • 13
    • 0842277812 scopus 로고    scopus 로고
    • Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1
    • Gui C.Y., et al. Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1. Proc. Natl. Acad. Sci. U. S. A. 2004, 101(5):1241-1246.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , Issue.5 , pp. 1241-1246
    • Gui, C.Y.1
  • 14
    • 1842631408 scopus 로고    scopus 로고
    • Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer
    • Halkidou K., et al. Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate 2004, 59(2):177-189.
    • (2004) Prostate , vol.59 , Issue.2 , pp. 177-189
    • Halkidou, K.1
  • 15
    • 79958218684 scopus 로고    scopus 로고
    • Expression of histone deacetylase 1 and metastasis-associated protein 1 as prognostic factors in colon cancer
    • Higashijima J., et al. Expression of histone deacetylase 1 and metastasis-associated protein 1 as prognostic factors in colon cancer. Oncol. Rep. 2011, 26(2):343-348.
    • (2011) Oncol. Rep. , vol.26 , Issue.2 , pp. 343-348
    • Higashijima, J.1
  • 16
    • 33751260934 scopus 로고    scopus 로고
    • TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming
    • Iljin K., et al. TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. Cancer Res. 2006, 66(21):10242-10246.
    • (2006) Cancer Res. , vol.66 , Issue.21 , pp. 10242-10246
    • Iljin, K.1
  • 17
    • 79952232216 scopus 로고    scopus 로고
    • Global cancer statistics
    • Jemal A., et al. Global cancer statistics. CA Cancer J. Clin. 2011, 61(2):69-90.
    • (2011) CA Cancer J. Clin. , vol.61 , Issue.2 , pp. 69-90
    • Jemal, A.1
  • 18
    • 84884417912 scopus 로고    scopus 로고
    • High expression of SNIP1 correlates with poor prognosis in non-small cell lung cancer and SNIP1 interferes with the recruitment of HDAC1 to RB in vitro
    • Jeon H.S., et al. High expression of SNIP1 correlates with poor prognosis in non-small cell lung cancer and SNIP1 interferes with the recruitment of HDAC1 to RB in vitro. Lung Cancer 2013, 82(1):24-30.
    • (2013) Lung Cancer , vol.82 , Issue.1 , pp. 24-30
    • Jeon, H.S.1
  • 19
    • 64249128160 scopus 로고    scopus 로고
    • Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer
    • Jhavar S., et al. Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer. BJU Int. 2009, 103(9):1256-1269.
    • (2009) BJU Int. , vol.103 , Issue.9 , pp. 1256-1269
    • Jhavar, S.1
  • 20
    • 33644848879 scopus 로고    scopus 로고
    • Cytosolic overexpression of p62 sequestosome 1 in neoplastic prostate tissue
    • Kitamura H., et al. Cytosolic overexpression of p62 sequestosome 1 in neoplastic prostate tissue. Histopathology 2006, 48(2):157-161.
    • (2006) Histopathology , vol.48 , Issue.2 , pp. 157-161
    • Kitamura, H.1
  • 21
    • 84879947917 scopus 로고    scopus 로고
    • Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions
    • Kluth M., et al. Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions. Mod. Pathol. 2013, 26(7):975-983.
    • (2013) Mod. Pathol. , vol.26 , Issue.7 , pp. 975-983
    • Kluth, M.1
  • 22
    • 0031822837 scopus 로고    scopus 로고
    • Tissue microarrays for high-throughput molecular profiling of tumor specimens
    • Kononen J., et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat. Med. 1998, 4(7):844-847.
    • (1998) Nat. Med. , vol.4 , Issue.7 , pp. 844-847
    • Kononen, J.1
  • 23
    • 84864141538 scopus 로고    scopus 로고
    • Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer
    • Krohn A., et al. Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer. Am. J. Pathol. 2012, 181(2):401-412.
    • (2012) Am. J. Pathol. , vol.181 , Issue.2 , pp. 401-412
    • Krohn, A.1
  • 24
    • 84885132388 scopus 로고    scopus 로고
    • Recurrent deletion of 3p13 targets multiple tumour suppressor genes and defines a distinct subgroup of aggressive ERG fusion-positive prostate cancers
    • Krohn A., et al. Recurrent deletion of 3p13 targets multiple tumour suppressor genes and defines a distinct subgroup of aggressive ERG fusion-positive prostate cancers. J. Pathol. 2013, 231(1):130-141.
    • (2013) J. Pathol. , vol.231 , Issue.1 , pp. 130-141
    • Krohn, A.1
  • 25
    • 16844385708 scopus 로고    scopus 로고
    • Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysis
    • Krusche C.A., et al. Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysis. Breast Cancer Res. Treat. 2005, 90(1):15-23.
    • (2005) Breast Cancer Res. Treat. , vol.90 , Issue.1 , pp. 15-23
    • Krusche, C.A.1
  • 26
    • 18444414332 scopus 로고    scopus 로고
    • Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
    • Lagger G., et al. Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. 2002, 21(11):2672-2681.
    • (2002) EMBO J. , vol.21 , Issue.11 , pp. 2672-2681
    • Lagger, G.1
  • 27
    • 0034676439 scopus 로고    scopus 로고
    • Deacetylation of p53 modulates its effect on cell growth and apoptosis
    • Luo J., et al. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 2000, 408(6810):377-381.
    • (2000) Nature , vol.408 , Issue.6810 , pp. 377-381
    • Luo, J.1
  • 28
    • 77956341931 scopus 로고    scopus 로고
    • Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
    • Miller K.M., et al. Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat. Struct. Mol. Biol. 2010, 17(9):1144-1151.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , Issue.9 , pp. 1144-1151
    • Miller, K.M.1
  • 29
    • 80053627793 scopus 로고    scopus 로고
    • Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung
    • Minamiya Y., et al. Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung. Lung Cancer 2011, 74(2):300-304.
    • (2011) Lung Cancer , vol.74 , Issue.2 , pp. 300-304
    • Minamiya, Y.1
  • 30
    • 77649108628 scopus 로고    scopus 로고
    • Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer
    • Minner S., et al. Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer. Clin. Cancer Res. 2010, 16(5):1553-1560.
    • (2010) Clin. Cancer Res. , vol.16 , Issue.5 , pp. 1553-1560
    • Minner, S.1
  • 31
    • 80052841071 scopus 로고    scopus 로고
    • ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy
    • Minner S., et al. ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy. Clin. Cancer Res. 2011, 17(18):5878-5888.
    • (2011) Clin. Cancer Res. , vol.17 , Issue.18 , pp. 5878-5888
    • Minner, S.1
  • 32
    • 77956309330 scopus 로고    scopus 로고
    • Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia
    • Moreno D.A., et al. Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia. Br. J. Haematol. 2010, 150(6):665-673.
    • (2010) Br. J. Haematol. , vol.150 , Issue.6 , pp. 665-673
    • Moreno, D.A.1
  • 33
    • 84876795104 scopus 로고    scopus 로고
    • Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer-overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression
    • Muller B.M., et al. Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer-overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression. BMC Cancer 2013, 13:215.
    • (2013) BMC Cancer , vol.13 , pp. 215
    • Muller, B.M.1
  • 34
    • 38449100788 scopus 로고    scopus 로고
    • Expression profile of class I histone deacetylases in human cancer tissues
    • Nakagawa M., et al. Expression profile of class I histone deacetylases in human cancer tissues. Oncol. Rep. 2007, 18(4):769-774.
    • (2007) Oncol. Rep. , vol.18 , Issue.4 , pp. 769-774
    • Nakagawa, M.1
  • 35
    • 64949190804 scopus 로고    scopus 로고
    • MiR-449a targets HDAC-1 and induces growth arrest in prostate cancer
    • Noonan E.J., et al. miR-449a targets HDAC-1 and induces growth arrest in prostate cancer. Oncogene 2009, 28(14):1714-1724.
    • (2009) Oncogene , vol.28 , Issue.14 , pp. 1714-1724
    • Noonan, E.J.1
  • 36
    • 34250171437 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: signalling towards p21cip1/waf1
    • Ocker M., Schneider-Stock R. Histone deacetylase inhibitors: signalling towards p21cip1/waf1. Int. J. Biochem. Cell Biol. 2007, 39(7-8):1367-1374.
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , Issue.7-8 , pp. 1367-1374
    • Ocker, M.1    Schneider-Stock, R.2
  • 37
    • 14944385553 scopus 로고    scopus 로고
    • Global cancer statistics, 2002
    • Parkin D.M., et al. Global cancer statistics, 2002. CA Cancer J. Clin. 2005, 55(2):74-108.
    • (2005) CA Cancer J. Clin. , vol.55 , Issue.2 , pp. 74-108
    • Parkin, D.M.1
  • 38
    • 77951884767 scopus 로고    scopus 로고
    • A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer
    • Rathkopf D., et al. A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer. Cancer Chemother. Pharmacol. 2010, 66(1):181-189.
    • (2010) Cancer Chemother. Pharmacol. , vol.66 , Issue.1 , pp. 181-189
    • Rathkopf, D.1
  • 39
    • 84883487383 scopus 로고    scopus 로고
    • A phase 2 study of intravenous panobinostat in patients with castration-resistant prostate cancer
    • Rathkopf D.E., et al. A phase 2 study of intravenous panobinostat in patients with castration-resistant prostate cancer. Cancer Chemother. Pharmacol. 2013, 72(3):537-544.
    • (2013) Cancer Chemother. Pharmacol. , vol.72 , Issue.3 , pp. 537-544
    • Rathkopf, D.E.1
  • 40
    • 2942755609 scopus 로고    scopus 로고
    • Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia
    • Romanski A., et al. Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia. Haematologica 2004, 89(4):419-426.
    • (2004) Haematologica , vol.89 , Issue.4 , pp. 419-426
    • Romanski, A.1
  • 41
    • 82555182729 scopus 로고    scopus 로고
    • Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study
    • Samartzis N., et al. Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study. BMC Cancer 2011, 11:463.
    • (2011) BMC Cancer , vol.11 , pp. 463
    • Samartzis, N.1
  • 42
    • 57749108319 scopus 로고    scopus 로고
    • Clinical significance of p53 alterations in surgically treated prostate cancers
    • Schlomm T., et al. Clinical significance of p53 alterations in surgically treated prostate cancers. Mod. Pathol. 2008, 21(11):1371-1378.
    • (2008) Mod. Pathol. , vol.21 , Issue.11 , pp. 1371-1378
    • Schlomm, T.1
  • 43
    • 0038677606 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation
    • Shin H.J., et al. Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation. Oncogene 2003, 22(25):3853-3858.
    • (2003) Oncogene , vol.22 , Issue.25 , pp. 3853-3858
    • Shin, H.J.1
  • 44
    • 79954591057 scopus 로고    scopus 로고
    • The significance of strong histone deacetylase 1 expression in the progression of prostate cancer
    • Song Y., et al. The significance of strong histone deacetylase 1 expression in the progression of prostate cancer. Histopathology 2011, 58(5):773-780.
    • (2011) Histopathology , vol.58 , Issue.5 , pp. 773-780
    • Song, Y.1
  • 45
    • 84879421374 scopus 로고    scopus 로고
    • Strong expression of the neuronal transcription factor FOXP2 is linked to an increased risk of early PSA recurrence in ERG fusion-negative cancers
    • Stumm L., et al. Strong expression of the neuronal transcription factor FOXP2 is linked to an increased risk of early PSA recurrence in ERG fusion-negative cancers. J. Clin. Pathol. 2013, 66(7):563-568.
    • (2013) J. Clin. Pathol. , vol.66 , Issue.7 , pp. 563-568
    • Stumm, L.1
  • 46
    • 27344451557 scopus 로고    scopus 로고
    • Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    • Tomlins S.A., et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005, 310(5748):644-648.
    • (2005) Science , vol.310 , Issue.5748 , pp. 644-648
    • Tomlins, S.A.1
  • 47
    • 38949086502 scopus 로고    scopus 로고
    • Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
    • Weichert W., et al. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br. J. Cancer 2008, 98(3):604-610.
    • (2008) Br. J. Cancer , vol.98 , Issue.3 , pp. 604-610
    • Weichert, W.1
  • 48
    • 38549157208 scopus 로고    scopus 로고
    • Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis
    • Weichert W., et al. Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis. Lancet Oncol. 2008, 9(2):139-148.
    • (2008) Lancet Oncol. , vol.9 , Issue.2 , pp. 139-148
    • Weichert, W.1
  • 49
    • 84873607610 scopus 로고    scopus 로고
    • Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer
    • Weischenfeldt J., et al. Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell 2013, 23(2):159-170.
    • (2013) Cancer Cell , vol.23 , Issue.2 , pp. 159-170
    • Weischenfeldt, J.1
  • 50
    • 84892942381 scopus 로고    scopus 로고
    • New and emerging HDAC inhibitors for cancer treatment
    • West A.C., Johnstone R.W. New and emerging HDAC inhibitors for cancer treatment. J. Clin. Invest. 2014, 124(1):30-39.
    • (2014) J. Clin. Invest. , vol.124 , Issue.1 , pp. 30-39
    • West, A.C.1    Johnstone, R.W.2
  • 51
    • 84885146283 scopus 로고    scopus 로고
    • Targeting prostate cancer cell lines with polo-like kinase 1 inhibitors as a single agent and in combination with histone deacetylase inhibitors
    • Wissing M.D., et al. Targeting prostate cancer cell lines with polo-like kinase 1 inhibitors as a single agent and in combination with histone deacetylase inhibitors. FASEB J. 2013, 27(10):4279-4293.
    • (2013) FASEB J. , vol.27 , Issue.10 , pp. 4279-4293
    • Wissing, M.D.1
  • 52
    • 84883137069 scopus 로고    scopus 로고
    • Combination therapy with the histone deacetylase inhibitor LBH589 and radiation is an effective regimen for prostate cancer cells
    • Xiao W., et al. Combination therapy with the histone deacetylase inhibitor LBH589 and radiation is an effective regimen for prostate cancer cells. PLoS ONE 2013, 8(8):e74253.
    • (2013) PLoS ONE , vol.8 , Issue.8 , pp. e74253
    • Xiao, W.1
  • 53
    • 76749159433 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation
    • Zupkovitz G., et al. The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. Mol. Cell. Biol. 2010, 30(5):1171-1181.
    • (2010) Mol. Cell. Biol. , vol.30 , Issue.5 , pp. 1171-1181
    • Zupkovitz, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.