Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: A tissue microarray study

BMC Cancer

Volumn 11, Issue , 2011, Pages

  Samartzis, Nicolas ^a   Imesch, Patrick ^a   Dedes, Konstantin J ^a   Samartzis, Eleftherios P ^a   Fedier, André ^a   Fink, Daniel ^a   Caduff, Rosmarie ^b   Fehr, Mathias K ^c  

^a UNIVERSITÄTSSPITAL ZÜRICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c Kantonsspital Frauenfeld   (Switzerland)

Author keywords

Epigenetics; Histone deacetylase; Immunohistochemistry; Tissue microarray; Vulvar intraepithelial neoplasia; Vulvar squamous cell cancer

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; TUMOR PROTEIN;

ADULT; AGED; ARTICLE; CARCINOMA IN SITU; CLINICAL FEATURE; CONTROLLED STUDY; ENZYME INHIBITION; EPIGENETICS; FEMALE; GENETIC REGULATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; PROTEIN TARGETING; TISSUE MICROARRAY; TUMOR SUPPRESSOR GENE; VAGINAL INTRAEPITHELIAL NEOPLASIA; VULVA CANCER; CANCER INVASION; ENZYMOLOGY; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOLOGY; SQUAMOUS CELL CARCINOMA; VULVA TUMOR;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA IN SITU; CARCINOMA, SQUAMOUS CELL; FEMALE; HISTONE DEACETYLASE 1; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; TISSUE ARRAY ANALYSIS; VULVAR NEOPLASMS; YOUNG ADULT;

EID: 82555182729     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-463     Document Type: Article

References (37)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009, 59(4):225-249. 10.3322/caac.20006, 19474385.
2. Howe HL, Wingo PA, Thun MJ, Ries LA, Rosenberg HM, Feigal EG, Edwards BK. Annual report to the nation on the status of cancer (1973 through 1998), featuring cancers with recent increasing trends. J Natl Cancer Inst 2001, 93(11):824-842. 10.1093/jnci/93.11.824, 11390532.
3. Judson PL, Habermann EB, Baxter NN, Durham SB, Virnig BA. Trends in the incidence of invasive and in situ vulvar carcinoma. Obstet Gynecol 2006, 107(5):1018-1022. 10.1097/01.AOG.0000210268.57527.a1, 16648405.
4. Moore DH. Chemotherapy and radiation therapy in the treatment of squamous cell carcinoma of the vulva: Are two therapies better than one?. Gynecol Oncol 2009, 113(3):379-383. 10.1016/j.ygyno.2009.01.004, 19232700.
5. Ghurani GB, Penalver MA. An update on vulvar cancer. Am J Obstet Gynecol 2001, 185(2):294-299. 10.1067/mob.2001.117401, 11518882.
6. Manchana T, Ittiwut C, Mutirangura A, Kavanagh JJ. Targeted therapies for rare gynaecological cancers. Lancet Oncol 11(7):685-693.
7. Bernstein BE, Meissner A, Lander ES. The mammalian epigenome. Cell 2007, 128(4):669-681. 10.1016/j.cell.2007.01.033, 17320505.
8. Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007, 128(4):683-692. 10.1016/j.cell.2007.01.029, 17320506.
9. Kouzarides T. Chromatin modifications and their function. Cell 2007, 128(4):693-705. 10.1016/j.cell.2007.02.005, 17320507.
10. Glozak MA, Rogers MB. Retinoic acid- and bone morphogenetic protein 4-induced apoptosis in P19 embryonal carcinoma cells requires p27. Exp Cell Res 2001, 268(2):128-138. 10.1006/excr.2001.5281, 11478839.
11. Glozak MA, Seto E. Histone deacetylases and cancer. Oncogene 2007, 26(37):5420-5432. 10.1038/sj.onc.1210610, 17694083.
12. Halkidou K, Gaughan L, Cook S, Leung HY, Neal DE, Robson CN. Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate 2004, 59(2):177-189. 10.1002/pros.20022, 15042618.
13. Song J, Noh JH, Lee JH, Eun JW, Ahn YM, Kim SY, Lee SH, Park WS, Yoo NJ, Lee JY, et al. Increased expression of histone deacetylase 2 is found in human gastric cancer. APMIS 2005, 113(4):264-268. 10.1111/j.1600-0463.2005.apm_04.x, 15865607.
14. Huang BH, Laban M, Leung CH, Lee L, Lee CK, Salto-Tellez M, Raju GC, Hooi SC. Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1. Cell Death Differ 2005, 12(4):395-404. 10.1038/sj.cdd.4401567, 15665816.
15. Hrzenjak A, Moinfar F, Kremser ML, Strohmeier B, Staber PB, Zatloukal K, Denk H. Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells. Mol Cancer Ther 2006, 5(9):2203-2210. 10.1158/1535-7163.MCT-05-0480, 16985053.
16. Sideri M, Jones RW, Wilkinson EJ, Preti M, Heller DS, Scurry J, Haefner H, Neill S. Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. J Reprod Med 2005, 50(11):807-810.
17. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998, 4(7):844-847. 10.1038/nm0798-844, 9662379.
18. Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T. Immunohistochemical overexpression of p16 protein associated with intact retinoblastoma protein expression in cervical cancer and cervical intraepithelial neoplasia. Pathol Int 1998, 48(8):580-585. 10.1111/j.1440-1827.1998.tb03954.x, 9736404.
19. Santos M, Montagut C, Mellado B, Garcia A, Ramon y Cajal S, Cardesa A, Puig-Tintore LM, Ordi J. Immunohistochemical staining for p16 and p53 in premalignant and malignant epithelial lesions of the vulva. Int J Gynecol Pathol 2004, 23(3):206-214. 10.1097/01.pgp.0000130108.03231.89, 15213596.
20. Riethdorf S, Neffen EF, Cviko A, Loning T, Crum CP, Riethdorf L. p16INK4A expression as biomarker for HPV 16-related vulvar neoplasias. Hum Pathol 2004, 35(12):1477-1483. 10.1016/j.humpath.2004.09.004, 15619206.
21. Santos M, Landolfi S, Olivella A, Lloveras B, Klaustermeier J, Suarez H, Alos L, Puig-Tintore LM, Campo E, Ordi J. p16 overexpression identifies HPV-positive vulvar squamous cell carcinomas. Am J Surg Pathol 2006, 30(11):1347-1356. 10.1097/01.pas.0000213251.82940.bf, 17063073.
22. Biedermann K, Dandachi N, Trattner M, Vogl G, Doppelmayr H, More E, Staudach A, Dietze O, Hauser-Kronberger C. Comparison of real-time PCR signal-amplified in situ hybridization and conventional PCR for detection and quantification of human papillomavirus in archival cervical cancer tissue. J Clin Microbiol 2004, 42(8):3758-3765. 10.1128/JCM.42.8.3758-3765.2004, 497646, 15297527.
23. O'Neill CJ, McCluggage WG. p16 expression in the female genital tract and its value in diagnosis. Adv Anat Pathol 2006, 13(1):8-15. 10.1097/01.pap.0000201828.92719.f3, 16462152.
24. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000, 182(3):311-322. 10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9, 10653597.
25. Weichert W, Roske A, Gekeler V, Beckers T, Ebert MP, Pross M, Dietel M, Denkert C, Rocken C. Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis. Lancet Oncol 2008, 9(2):139-148. 10.1016/S1470-2045(08)70004-4, 18207460.
26. Marks P, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 2001, 1(3):194-202. 10.1038/35106079, 11902574.
27. Weichert W, Roske A, Gekeler V, Beckers T, Stephan C, Jung K, Fritzsche FR, Niesporek S, Denkert C, Dietel M, et al. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br J Cancer 2008, 98(3):604-610. 10.1038/sj.bjc.6604199, 2243142, 18212746.
28. Weichert W, Roske A, Niesporek S, Noske A, Buckendahl AC, Dietel M, Gekeler V, Boehm M, Beckers T, Denkert C. Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin Cancer Res 2008, 14(6):1669-1677. 10.1158/1078-0432.CCR-07-0990, 18347167.
29. Munster PN, Troso-Sandoval T, Rosen N, Rifkind R, Marks PA, Richon VM. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells. Cancer Res 2001, 61(23):8492-8497.
30. Imesch P, Fink D, Fedier A. Romidepsin reduces histone deacetylase activity, induces acetylation of histones, inhibits proliferation, and activates apoptosis in immortalized epithelial endometriotic cells. Fertil Steril 2010,
31. Li X, Chen BD. Histone Deacetylase Inhibitor M344 Inhibits Cell Proliferation and Induces Apoptosis in Human THP-1 Leukemia Cells. Am J Biomed Sci 2009, 1(4):352-363. 2880493, 20526416.
32. Hrzenjak A, Moinfar F, Kremser ML, Strohmeier B, Petru E, Zatloukal K, Denk H. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer 2010, 9:49. 10.1186/1476-4598-9-49, 2843655, 20202195.
33. Tan J, Cang S, Ma Y, Petrillo RL, Liu D. Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents. J Hematol Oncol 2010, 3:5. 10.1186/1756-8722-3-5, 2827364, 20132536.
34. Kim J, Guan J, Chang I, Chen X, Han D, Wang CY. PS-341 and histone deacetylase inhibitor synergistically induce apoptosis in head and neck squamous cell carcinoma cells. Mol Cancer Ther 9(7):1977-1984.
35. Shen J, Huang C, Jiang L, Gao F, Wang Z, Zhang Y, Bai J, Zhou H, Chen Q. Enhancement of cisplatin induced apoptosis by suberoylanilide hydroxamic acid in human oral squamous cell carcinoma cell lines. Biochem Pharmacol 2007, 73(12):1901-1909. 10.1016/j.bcp.2007.03.009, 17445779.
36. Chung YL, Lee MY, Pui NN. Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis. Carcinogenesis 2009, 30(8):1387-1397. 10.1093/carcin/bgp079, 19351790.
37. Murakami J, Asaumi J, Kawai N, Tsujigiwa H, Yanagi Y, Nagatsuka H, Inoue T, Kokeguchi S, Kawasaki S, Kuroda M, et al. Effects of histone deacetylase inhibitor FR901228 on the expression level of telomerase reverse transcriptase in oral cancer. Cancer Chemother Pharmacol 2005, 56(1):22-28. 10.1007/s00280-004-0976-x, 15791453.