Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

Haematologica

Volumn 100, Issue 4, 2015, Pages 458-465

  Pagani, Alessia ^a,b   Vieillevoye, Maud ^c,d   Nai, Antonella ^a,b   Rausa, Marco ^a,b   Ladli, Meriem ^c,d   Lacombe, Catherine ^c,d   Mayeux, Patrick ^c,d   Verdier, Frédérique ^c,d   Camaschella, Clara ^a,b   Silvestri, Laura ^a,b  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c INSTITUT COCHIN   (France)

^d Center de Recherche des Cordeliers   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; ERYTHROPOIETIN RECEPTOR; HEPCIDIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; STAT5 PROTEIN; TRANSFERRIN RECEPTOR 2; CD71 ANTIGEN; ERYTHROPOIETIN; HOLOTRANSFERRIN; IRON; LEUKOCYTE ANTIGEN; PROTEIN BINDING; TFR2 PROTEIN, HUMAN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ARTICLE; BINDING ASSAY; CELL MEMBRANE; CONTROLLED STUDY; ERYTHROID CELL; ERYTHROPOIESIS; GENETIC TRANSFECTION; HEPATOMA CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; IRON DEFICIENCY; IRON OVERLOAD; LUCIFERASE ASSAY; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REGULATORY MECHANISM; WESTERN BLOTTING; BLOOD; CELL LINE; GENE EXPRESSION; GENETICS; METABOLISM; MUTATION; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN TRANSPORT; TRANSCRIPTION INITIATION;

ANTIGENS, CD; CELL LINE; CELL MEMBRANE; ERYTHROID CELLS; ERYTHROPOIETIN; GENE EXPRESSION; HEPCIDINS; HUMANS; IRON; MUTATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEOLYSIS; RECEPTORS, ERYTHROPOIETIN; RECEPTORS, TRANSFERRIN; TRANSCRIPTIONAL ACTIVATION; TRANSFERRIN;

EID: 84926337889     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2014.118521     Document Type: Article

References (34)

1. Kawabata H, Yang R, Hirama T, et al. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptorlike family. J Biol Chem. 1999;274(30): 20826-20832.
2. Camaschella C, Roetto A, Cali A, et al. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet. 2000;25(1):14-15.
3. Wallace DF, Summerville L, Lusby PE, Subramaniam VN. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut. 2005;54(7):980-986.
4. Johnson MB, Chen J, Murchison N, Green FA, Enns CA. Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway. Mol Biol Cell. 2007;18(3):743-754.
5. Roetto A, Di Cunto F, Pellegrino RM, et al. Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues. Blood. 2010;115(16):3382-3389.
6. Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. Hepcidin is decreased in TFR2 hemochromatosis. Blood. 2005;105(4): 1803-1806.
7. Fleming RE, Migas MC, Holden CC, et al. Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci USA. 2000;97(5):2214-2219.
8. Kawabata H, Germain RS, Ikezoe T, et al. Regulation of expression of murine transferrin receptor 2. Blood. 2001;98(6):1949-1954.
9. Camaschella C, Roetto, A. TFR2-related hereditary hemochromatosis. GeneReviews (Internet). 2011 update 2011 Jun 09.
10. Johnson MB, Enns CA. Diferric transferrin regulates transferrin receptor 2 protein stability. Blood. 2004;104(13):4287-4293.
11. D'Alessio F, Hentze MW, Muckenthaler MU. The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation. J Hepatol. 2012;57(5):1052-1060.
12. Chen J, Enns CA. Hereditary hemochromatosis and transferrin receptor 2. Biochim Biophys Acta. 2012;1820(3):256-263.
13. Rishi G, Crampton EM, Wallace DF, Subramaniam VN. In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact. PLoS One. 2013;8(10):e77267.
14. Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, Subramaniam VN. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology. 2009;50(6):1992-2000.
15. Girelli D, Trombini P, Busti F, et al. A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis. Haematologica. 2011;96 (4):500-506.
16. Kawabata H, Nakamaki T, Ikonomi P, Smith RD, Germain RS, Koeffler HP. Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells. Blood. 2001;98(9): 2714-2719.
17. Forejtnikova H, Vieillevoye M, Zermati Y et al. Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis. Blood. 2010;116(24):5357-5367.
18. Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta. 2003;329(1-2):9-22.
19. Skikne BS. Serum transferrin receptor. Am J Hematol. 2008;83(11):872-875.
20. Guillemot J, Canuel M, Essalmani R, Prat A, Seidah NG. Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin. Hepatology. 2013;57(6):2514-2524.
21. Oexle K, Ried JS, Hicks AA, et al. Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels. Hum Mol Genet. 2011;20(5):1042-1047.
22. De Domenico I, Ward DM, Langelier C, et al. The molecular mechanism of hepcidinmediated ferroportin down-regulation. Mol Biol Cell. 2007;18(7):2569-2578.
23. Pagani A, Silvestri L, Nai A, Camaschella C. Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response. Haematologica. 2008;93 (10):1466-1472.
24. Shih YJ, Baynes RD, Hudson BG, Flowers CH, Skikne BS, Cook JD. Serum transferrin receptor is a truncated form of tissue receptor. J Biol Chem. 1990;265(31):19077-19081.
25. Traub LM, Kornfeld S. The trans-Golgi network: a late secretory sorting station. Curr Opin Cell Biol. 1997;9(4):527-33.
26. Altschuler Y, Barbas SM, Terlecky LJ et al. Redundant and distinct functions for dynamin-1 and dynamin-2 isoforms. J Cell Biol. 1998;143(7):1871-1881.
27. Dassler K, Zydek M, Wandzik K, Kaup M, Fuchs H. Release of the soluble transferrin receptor is directly regulated by binding of its ligand ferritransferrin. J Biol Chem. 2006;281(6):3297-3304.
28. Kawabata H, Tong X, Kawanami, T et al. Analyses for binding of the transferrin family of proteins to the transferrin receptor 2. Br J Haematol. 2004;127(4):464-473.
29. Kawabata H, Germain RS, Vuong PT, Nakamaki T, Said JW, Koeffler HP. Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo. J Biol Chem. 2000;275(22): 16618-16625.
30. Nai A, Lidonnici MR, Rausa M, et al. The second transferrin receptor regulates red blood cell production in mice. Blood. 2015;125(7):1170-1179.
31. Silvestri L, Pagani A, Camaschella C. Furinmediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Blood. 2008;111(2):924-931.
32. Babitt JL, Huang FW, Wrighting DM, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006;38(5):531-539.
33. Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T. Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis. 2008;40(1):122-131.
34. Nai A, Pellegrino RM, Rausa M, et al. The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice. Haematologica. 2014;99(6):1016-1021.