-
1
-
-
0026665952
-
Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell typespecific processing of human prorenin by the convertase PC1
-
Benjannet S, Reudelhuber T, Mercure C, Rondeau N, Chretien M, Seidah NG. Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell typespecific processing of human prorenin by the convertase PC1. J Biol Chem 1992; 267(16): 11417-11423.
-
(1992)
J Biol Chem
, vol.267
, Issue.16
, pp. 11417-11423
-
-
Benjannet, S.1
Reudelhuber, T.2
Mercure, C.3
Rondeau, N.4
Chretien, M.5
Seidah, N.G.6
-
2
-
-
34548765134
-
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3
-
Farooqi IS, Volders K, Stanhope R, Heuschkel R, White A, Lank E et al. Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3. J Clin Endocrinol Metab 2007; 92(9): 3369-3373.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, Issue.9
, pp. 3369-3373
-
-
Farooqi, I.S.1
Volders, K.2
Stanhope, R.3
Heuschkel, R.4
White, A.5
Lank, E.6
-
3
-
-
33750109567
-
Proprotein convertases: Lessons from knockouts
-
Scamuffa N, Calvo F, Chretien M, Seidah NG, Khatib AM. Proprotein convertases: lessons from knockouts. FASEB J 2006; 20(12): 1954-1963.
-
(2006)
FASEB J
, vol.20
, Issue.12
, pp. 1954-1963
-
-
Scamuffa, N.1
Calvo, F.2
Chretien, M.3
Seidah, N.G.4
Khatib, A.M.5
-
4
-
-
0346096721
-
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
-
Jackson RS, Creemers JW, Farooqi IS, Raffin-Sanson ML, Varro A, Dockray GJ et al. Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J Clin Invest 2003; 112(10): 1550-1560.
-
(2003)
J Clin Invest
, vol.112
, Issue.10
, pp. 1550-1560
-
-
Jackson, R.S.1
Creemers, J.W.2
Farooqi, I.S.3
Raffin-Sanson, M.L.4
Varro, A.5
Dockray, G.J.6
-
5
-
-
0030949271
-
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
-
Jackson RS, Creemers JW, Ohagi S, Raffin-Sanson ML, Sanders L, Montague CT et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 1997; 16(3): 303-306.
-
(1997)
Nat Genet
, vol.16
, Issue.3
, pp. 303-306
-
-
Jackson, R.S.1
Creemers, J.W.2
Ohagi, S.3
Raffin-Sanson, M.L.4
Sanders, L.5
Montague, C.T.6
-
6
-
-
84856523505
-
Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity
-
Creemers JW, Choquet H, Stijnen P, Vatin V, Pigeyre M, Beckers S et al. Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity. Diabetes 2012; 61(2): 383-390.
-
(2012)
Diabetes
, vol.61
, Issue.2
, pp. 383-390
-
-
Creemers, J.W.1
Choquet, H.2
Stijnen, P.3
Vatin, V.4
Pigeyre, M.5
Beckers, S.6
-
7
-
-
84879480364
-
Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort
-
Martin MG, Lindberg I, Solorzano-Vargas RS, Wang J, Avitzur Y, Bandsma R et al. Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort. Gastroenterology 2013; 145(1): 138-148.
-
(2013)
Gastroenterology
, vol.145
, Issue.1
, pp. 138-148
-
-
Martin, M.G.1
Lindberg, I.2
Solorzano-Vargas, R.S.3
Wang, J.4
Avitzur, Y.5
Bandsma, R.6
-
8
-
-
84889644321
-
Exome sequencing finds a novel PCSK1 mutation in a child with generalized malabsorptive diarrhea and diabetes insipidus
-
Yourshaw M, Solorzano-Vargas RS, Pickett LA, Lindberg I, Wang J, Cortina G et al. Exome sequencing finds a novel PCSK1 mutation in a child with generalized malabsorptive diarrhea and diabetes insipidus. J Pediatr Gastroenterol Nutr 2013; 57(6): 759-767.
-
(2013)
J Pediatr Gastroenterol Nutr
, vol.57
, Issue.6
, pp. 759-767
-
-
Yourshaw, M.1
Solorzano-Vargas, R.S.2
Pickett, L.A.3
Lindberg, I.4
Wang, J.5
Cortina, G.6
-
9
-
-
48349113289
-
Common nonsynonymous variants in PCSK1 confer risk of obesity
-
Benzinou M, Creemers JW, Choquet H, Lobbens S, Dina C, Durand E et al. Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet 2008; 40(8): 943-945.
-
(2008)
Nat Genet
, vol.40
, Issue.8
, pp. 943-945
-
-
Benzinou, M.1
Creemers, J.W.2
Choquet, H.3
Lobbens, S.4
Dina, C.5
Durand, E.6
-
10
-
-
77954145177
-
Common PCSK1 haplotypes are associated with obesity in the Chinese population
-
Chang YC, Chiu YF, Shih KC, Lin MW, Sheu WH, Donlon T et al. Common PCSK1 haplotypes are associated with obesity in the Chinese population. Obesity (Silver Spring, MD) 2010; 18(7): 1404-1409.
-
(2010)
Obesity (Silver Spring, MD)
, vol.18
, Issue.7
, pp. 1404-1409
-
-
Chang, Y.C.1
Chiu, Y.F.2
Shih, K.C.3
Lin, M.W.4
Sheu, W.H.5
Donlon, T.6
-
11
-
-
84874375410
-
Contribution of common PCSK1 genetic variants to obesity in 8359 subjects from multi-ethnic American population
-
Choquet H, Kasberger J, Hamidovic A, Jorgenson E. Contribution of common PCSK1 genetic variants to obesity in 8359 subjects from multi-ethnic American population. PLoS ONE 2013; 8(2): e57857.
-
(2013)
PLoS ONE
, vol.8
, Issue.2
, pp. e57857
-
-
Choquet, H.1
Kasberger, J.2
Hamidovic, A.3
Jorgenson, E.4
-
12
-
-
77956270115
-
Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population
-
Qi Q, Li H, Loos RJ, Liu C, Hu FB, Wu H et al. Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population. PLoS ONE 2010; 5(5): e10590.
-
(2010)
PLoS ONE
, vol.5
, Issue.5
, pp. e10590
-
-
Qi, Q.1
Li, H.2
Loos, R.J.3
Liu, C.4
Hu, F.B.5
Wu, H.6
-
13
-
-
84856278653
-
Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population
-
Rouskas K, Kouvatsi A, Paletas K, Papazoglou D, Tsapas A, Lobbens S et al. Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population. Obesity (Silver Spring. MD) 2012; 20(2): 389-395.
-
(2012)
Obesity (Silver Spring. MD)
, vol.20
, Issue.2
, pp. 389-395
-
-
Rouskas, K.1
Kouvatsi, A.2
Paletas, K.3
Papazoglou, D.4
Tsapas, A.5
Lobbens, S.6
-
14
-
-
84862653589
-
PCSK1 rs6232 is associated with childhood and adult class III obesity in the Mexican population
-
Villalobos-Comparan M, Villamil-Ramirez H, Villarreal-Molina T, Larrieta-Carrasco E, Leon-Mimila P, Romero-Hidalgo S et al. PCSK1 rs6232 is associated with childhood and adult class III obesity in the Mexican population. PLoS ONE 2012; 7(6): e39037.
-
(2012)
PLoS ONE
, vol.7
, Issue.6
, pp. 39037
-
-
Villalobos-Comparan, M.1
Villamil-Ramirez, H.2
Villarreal-Molina, T.3
Larrieta-Carrasco, E.4
Leon-Mimila, P.5
Romero-Hidalgo, S.6
-
15
-
-
84862777036
-
Meta-analysis identifies common variants associated with body mass index in east Asians
-
Wen W, Cho YS, Zheng W, Dorajoo R, Kato N, Qi L et al. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet 2012; 44(3): 307-311.
-
(2012)
Nat Genet
, vol.44
, Issue.3
, pp. 307-311
-
-
Wen, W.1
Cho, Y.S.2
Zheng, W.3
Dorajoo, R.4
Kato, N.5
Qi, L.6
-
16
-
-
69449093447
-
Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study
-
Kilpelainen TO, Bingham SA, Khaw KT, Wareham NJ, Loos RJ. Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study. Hum Mol Genet 2009; 18(18): 3496-3501.
-
(2009)
Hum Mol Genet
, vol.18
, Issue.18
, pp. 3496-3501
-
-
Kilpelainen, T.O.1
Bingham, S.A.2
Khaw, K.T.3
Wareham, N.J.4
Loos, R.J.5
-
17
-
-
64549158008
-
Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
-
Renstrom F, Payne F, Nordstrom A, Brito EC, Rolandsson O, Hallmans G et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet 2009; 18(8): 1489-1496.
-
(2009)
Hum Mol Genet
, vol.18
, Issue.8
, pp. 1489-1496
-
-
Renstrom, F.1
Payne, F.2
Nordstrom, A.3
Brito, E.C.4
Rolandsson, O.5
Hallmans, G.6
-
18
-
-
58149163142
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41(1): 25-34.
-
(2009)
Nat Genet
, vol.41
, Issue.1
, pp. 25-34
-
-
Willer, C.J.1
Speliotes, E.K.2
Loos, R.J.3
Li, S.4
Lindgren, C.M.5
Heid, I.M.6
-
19
-
-
0036896759
-
A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family
-
Martin LJ, Comuzzie AG, Dupont S, Vionnet N, Dina C, Gallina S et al. A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family. Diabetes 2002; 51(12): 3568-3572.
-
(2002)
Diabetes
, vol.51
, Issue.12
, pp. 3568-3572
-
-
Martin, L.J.1
Comuzzie, A.G.2
Dupont, S.3
Vionnet, N.4
Dina, C.5
Gallina, S.6
-
20
-
-
84881109625
-
Association of obesity susceptibility gene variants with metabolic syndrome and related traits in 1443 czech adolescents
-
Dusatkova L, Zamrazilova H, Sedlackova B, Vcelak J, Hlavaty P, Aldhoon Hainerova I et al. Association of obesity susceptibility gene variants with metabolic syndrome and related traits in 1443 czech adolescents. Folia Biol (Praha) 2013; 59(3): 123-133.
-
(2013)
Folia Biol (Praha)
, vol.59
, Issue.3
, pp. 123-133
-
-
Dusatkova, L.1
Zamrazilova, H.2
Sedlackova, B.3
Vcelak, J.4
Hlavaty, P.5
Aldhoon Hainerova, I.6
-
21
-
-
0031914212
-
Prohormone convertase 1 in obesity, gestational diabetes mellitus, and NIDDM: No evidence for a major susceptibility role
-
Kalidas K, Dow E, Saker PJ, Wareham N, Halsall D, Jackson RS et al. Prohormone convertase 1 in obesity, gestational diabetes mellitus, and NIDDM: no evidence for a major susceptibility role. Diabetes 1998; 47(2): 287-289.
-
(1998)
Diabetes
, vol.47
, Issue.2
, pp. 287-289
-
-
Kalidas, K.1
Dow, E.2
Saker, P.J.3
Wareham, N.4
Halsall, D.5
Jackson, R.S.6
-
22
-
-
0027946713
-
Proteolytic processing of human prorenin in renal and non-renal tissues
-
Reudelhuber TL, Ramla D, Chiu L, Mercure C, Seidah NG. Proteolytic processing of human prorenin in renal and non-renal tissues. Kidney Int 1994; 46(6): 1522-1524.
-
(1994)
Kidney Int
, vol.46
, Issue.6
, pp. 1522-1524
-
-
Reudelhuber, T.L.1
Ramla, D.2
Chiu, L.3
Mercure, C.4
Seidah, N.G.5
-
23
-
-
84887241858
-
Association of the rs6235 variant in the proprotein convertase subtilisin/kexin type 1 (PCSK1) gene with obesity and related traits in a Taiwanese population
-
Hsiao TJ, Hwang Y, Chang HM, Lin E. Association of the rs6235 variant in the proprotein convertase subtilisin/kexin type 1 (PCSK1) gene with obesity and related traits in a Taiwanese population. Gene 2014; 533(1): 32-37.
-
(2014)
Gene
, vol.533
, Issue.1
, pp. 32-37
-
-
Hsiao, T.J.1
Hwang, Y.2
Chang, H.M.3
Lin, E.4
-
24
-
-
84867199285
-
The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population
-
Li XM, Ling Y, Lu DR, Lu ZQ, Liu Y, Chen HY et al. The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population. Hypertens Res 2012; 35(10): 994-999.
-
(2012)
Hypertens Res
, vol.35
, Issue.10
, pp. 994-999
-
-
Li, X.M.1
Ling, Y.2
Lu, D.R.3
Lu, Z.Q.4
Liu, Y.5
Chen, H.Y.6
-
25
-
-
84890555012
-
The Rotterdam Study: 2014 objectives and design update
-
Hofman A, Darwish Murad S, van Duijn CM, Franco OH, Goedegebure A, Ikram MA et al. The Rotterdam Study: 2014 objectives and design update. Eur J Epidemiol 2013; 28(11): 889-926.
-
(2013)
Eur J Epidemiol
, vol.28
, Issue.11
, pp. 889-926
-
-
Hofman, A.1
Darwish Murad, S.2
Van Duijn, C.M.3
Franco, O.H.4
Goedegebure, A.5
Ikram, M.A.6
-
26
-
-
1842334456
-
Report of the expert committee on the diagnosis and classification of diabetes mellitus
-
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20(7): 1183-1197.
-
(1997)
Diabetes Care
, vol.20
, Issue.7
, pp. 1183-1197
-
-
-
27
-
-
0031851293
-
Definition, diagnosis and classification of diabetes mellitus and its complications Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
-
Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15(7): 539-553.
-
(1998)
Diabet Med
, vol.15
, Issue.7
, pp. 539-553
-
-
Alberti, K.G.1
Zimmet, P.Z.2
-
29
-
-
84882845778
-
Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency
-
Frank GR, Fox J, Candela N, Jovanovic Z, Bochukova E, Levine J et al. Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency. Mol Genet Metab 2013; 110(1-2): 191-194.
-
(2013)
Mol Genet Metab
, vol.110
, Issue.1-2
, pp. 191-194
-
-
Frank, G.R.1
Fox, J.2
Candela, N.3
Jovanovic, Z.4
Bochukova, E.5
Levine, J.6
-
30
-
-
0036679173
-
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
-
Zhu X, Zhou A, Dey A, Norrbom C, Carroll R, Zhang C et al. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci USA 2002; 99(16): 10293-10298.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.16
, pp. 10293-10298
-
-
Zhu, X.1
Zhou, A.2
Dey, A.3
Norrbom, C.4
Carroll, R.5
Zhang, C.6
-
31
-
-
0029032803
-
Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements
-
Jansen E, Ayoubi TA, Meulemans SM, Van de Ven WJ. Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements. J Biol Chem 1995; 270(25): 15391-15397.
-
(1995)
J Biol Chem
, vol.270
, Issue.25
, pp. 15391-15397
-
-
Jansen, E.1
Ayoubi, T.A.2
Meulemans, S.M.3
Van De Ven, W.J.4
-
32
-
-
80053405321
-
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
-
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011; 60(10): 2624-2634.
-
(2011)
Diabetes
, vol.60
, Issue.10
, pp. 2624-2634
-
-
Strawbridge, R.J.1
Dupuis, J.2
Prokopenko, I.3
Barker, A.4
Ahlqvist, E.5
Rybin, D.6
|