Gastrin-releasing peptide, substance P and cytokines in rheumatoid arthritis

Arthritis Research and Therapy

Volumn 7, Issue 3, 2005, Pages 111-113

  Green, Paul G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ANTIRHEUMATIC AGENT; BOMBESIN; ETANERCEPT; GASTRIN RELEASING PEPTIDE; INFLIXIMAB; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; RC 394011; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; SUBSTANCE P; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CYTOKINE PRODUCTION; DRUG EFFICACY; ERYTHROCYTE SEDIMENTATION RATE; IMMUNOMODULATION; MOLECULAR MECHANICS; PATHOPHYSIOLOGY; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

ANIMALS; ARTHRITIS, RHEUMATOID; CYTOKINES; GASTRIN-RELEASING PEPTIDE; HUMANS; SUBSTANCE P;

EID: 20144383909     PISSN: 14786354     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar1746     Document Type: Article

References (21)

1. Grimsholm O, Rantapaa-Dahlqvist S, Forsgren S: Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis. Arthritis Res Ther 2005, 7:R416-R426.
2. Eskandari F, Webster JI, Sternberg EM: Neural immune pathways and their connection to inflammatory diseases. Arthritis Res Ther 2003, 5:251-265.
3. Straub RH, Cutolo M: Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role. Arthritis Rheum 2001, 44:493-507.
4. Levine JD, Collier DH, Basbaum AI, Moskowitz MA, Helms CA: Hypothesis: the nervous system may contribute to the pathophysiology of rheumatoid arthritis. J Rheumatol 1985, 12:406-411.
5. Mapp PI, Kidd BL, Gibson SJ, Terry JM, Revell PA, Ibrahim NB, Blake DR, Polak JM: Substance P-, calcitonin gene-related peptide- and C-flanking peptide of neuropeptide Y-immunoreactive fibres are present in normal synovium but depleted in patients with rheumatoid arthritis. Neuroscience 1990, 37:143-153.
6. Grigg P: Properties of sensory neurons innervating synovial joints. Cells Tissues Organs 2001, 169:218-225.
7. Miller LE, Justen HP, Scholmerich J, Straub RH: The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages. FASEB J 2000, 14:2097-2107.
8. Niissalo S, Hukkanen M, Imai S, Tornwall J, Konttinen YT: Neuropeptides in experimental and degenerative arthritis. Ann N Y Acad Sci 2002, 966:384-399.
9. Cerinic MM, Konttinen Y, Generini S, Cutolo M: Neuropeptides and steroid hormones in arthritis. Curr Opin Rheumatol 1998, 10:220-235.
10. Odeh M: Role of cytokines in rheumatoid arthritis. Drug News Perspect 1998, 11:331-341.
11. Mariette X: Emerging biological therapies in rheumatoid arthritis. Joint Bone Spine 2004, 71:470-474.
12. McInnes IB, Gracie JA: Targeting cytokines beyond tumor necrosis factor-alpha and interleukin-1 in rheumatoid arthritis. Curr Rheumatol Rep 2004, 6:336-342.
13. Roberts LJ: New drugs for rheumatoid arthritis. N Engl J Med 2004, 351:2659-2661.
14. Klareskog L, van der Heijde D, de Jager JP, Gough A, Kalden J, Malaise M, Martin Mola E, Pavelka K, Sany J, Settas L, et al.: Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet 2004, 363:675-681.
15. O'Connor TM, O'Connell J, O'Brien DI, Goode T, Bredin CP, Shanahan F: The role of substance P in inflammatory disease. J Cell Physiol 2004, 201:167-180.
16. Bedoui S, Miyake S, Straub RH, von Horsten S, Yamamura T: More sympathy for autoimmunity with neuropeptide Y? Trends Immunol 2004, 25:508-512.
17. Keeble JE, Brain SD: A role for substance P in arthritis? Neurosci Lett 2004, 361:176-179.
18. Baerwald CG, Burmester GR, Krause A: Interactions of autonomic nervous, neuroendocrine, and immune systems in rheumatoid arthritis. Rheum Dis Clin North Am 2000, 26:841-857.
19. Westermark T, Rantapaa-Dahlqvist S, Wallberg-Jonsson S, Kjorell U, Forsgren S: Increased content of bombesin/GRP in human synovial fluid in early arthritis: different pattern compared with substance P. Clin Exp Rheumatol 2001, 19:715-720.
20. Cuesta MC, Quintero L, Pons H, Suarez-Roca H: Substance P and calcitonin gene-related peptide increase IL-1 beta, IL-6 and TNF alpha secretion from human peripheral blood mononuclear cells. Neurochem Int 2002, 40:301-306.
21. Delgado M, Pozo D, Ganea D: The significance of vasoactive intestinal peptide in immunomodulation. Pharmacol Rev 2004, 56:249-290.