Cellulose-based filter aids increase the capacity of depth filters during the downstream processing of plant-derived biopharmaceutical proteins

Biotechnology Journal

Volumn 10, Issue 4, 2015, Pages 584-591

  Buyel, Johannes Felix ^a   Opdensteinen, Patrick ^b   Fischer, Rainer ^a,b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

Author keywords

Bioprocess development; Design of experiments (DoE); Plant extract clarification; Plant derived biopharmaceuticals; Protein purification

Indexed keywords

ANTIBODIES; CELLULOSE; CLARIFIERS; COST REDUCTION; COSTS; DESIGN OF EXPERIMENTS; FILTERS (FOR FLUIDS); FLOCCULATION; MONOCLONAL ANTIBODIES; PROTEINS; TOBACCO;

BIOPHARMACEUTICAL PROTEINS; BIOPHARMACEUTICALS; BIOPROCESS DEVELOPMENT; DOWNSTREAM-PROCESSING; INCREASING CAPACITIES; INTRACELLULAR PROTEINS; PARTICULATE MATERIALS; PROTEIN PURIFICATION;

PLANT EXTRACTS;

CELLULOSE DERIVATIVE; DSRED PROTEIN; FLUORESCENT DYE; MONOCLONAL ANTIBODY 2G12; PLANT EXTRACT; RECOMBINANT PROTEIN; TOBACCO EXTRACT; UNCLASSIFIED DRUG; VEGETABLE PROTEIN; CELLULOSE;

ANTIBODY PRODUCTION; ARTICLE; BIOENGINEERING; CONCENTRATION (PARAMETERS); CONDUCTANCE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; EXPERIMENTAL DESIGN; FILTER; FILTER AID; FILTER CAKE; FILTRATION; FLOCCULATION; NORMAL VALUE; PARTICLE SIZE; PH; PLANT LEAF; PRIORITY JOURNAL; PROCESS DEVELOPMENT; BIOTECHNOLOGY; CHEMISTRY; DEVICES; ISOLATION AND PURIFICATION; METHODOLOGY; PROCEDURES;

NICOTIANA TABACUM;

BIOTECHNOLOGY; CELLULOSE; FILTRATION; PLANT PROTEINS; RESEARCH DESIGN;

EID: 84926165089     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201400611     Document Type: Article

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