Berberine reduces Toll-like receptor-mediated macrophage migration by suppression of Src enhancement

European Journal of Pharmacology

Volumn 757, Issue , 2015, Pages 1-10

  Cheng, Wei Erh ^a,b   Ying Chang, Miao ^b   Wei, Jyun Yan ^a   Chen, Yen Jen ^c   Maa, Ming Chei ^a   Leu, Tzeng Horng ^c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Berberine; Macrophage migration; Src; Toll like receptor

Indexed keywords

BERBERINE; CPG OLIGODEOXYNUCLEOTIDE; CYCLOOXYGENASE 2; FIBRONECTIN; FOCAL ADHESION KINASE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; N ACETYL S NITROSOPENICILLAMINE; PEPTIDOGLYCAN; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN TYROSINE KINASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; ANTIINFLAMMATORY AGENT; OLIGODEOXYRIBONUCLEOTIDE; POLYCYTIDYLIC ACID; PROTEIN KINASE P60;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL MOTILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; MACROPHAGE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL LINE RAW 264.7; CELL MOTION; CYTOLOGY; DRUG EFFECTS; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GENETICS; MACROPHAGE; METABOLISM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BERBERINE; CELL MOVEMENT; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; OLIGODEOXYRIBONUCLEOTIDES; PEPTIDOGLYCAN; POLY C; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RAW 264.7 CELLS; TOLL-LIKE RECEPTORS;

EID: 84926162229     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.03.013     Document Type: Article

References (45)

1. A.A. Akhand, M. Pu, T. Senga, M. Kato, H. Suzuki, T. Miyata, M. Hamaguchi, and I. Nakashima Nitric oxide controls src kinase activity through a sulfhydryl group modification-mediated Tyr-527-independent and Tyr-416-linked mechanism J. Biol. Chem. 274 1999 25821 25826
2. K.H. Baek, S.J. Ha, and Y.C. Sung A novel function of phosphorothioate oligodeoxynucleotides as chemoattractants for primary macrophages J. Immunol. 167 2001 2847 2854
3. G.J. Bellingan, H. Caldwell, S.E. Howie, I. Dransfield, and C. Haslett In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes J. Immunol. 157 1996 2577 2585
4. J.S. Biscardi, D.A. Tice, and S.J. Parsons c-Src, receptor tyrosine kinases, and human cancer Adv. Cancer Res. 76 1999 61 119
5. Y. Cai, Q. Xia, R. Luo, P. Huang, Y. Sun, Y. Shi, and W. Jiang Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo J. Nat. Med. 68 2014 53 62
6. M.B. Calalb, T.R. Polte, and S.K. Hanks Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases Mol. Cell. Biol. 15 1995 954 963
7. Y.F. Chen, D. Zhou, T. Metzger, M. Gallup, M. Jeanne, D.B. Gould, M.S. Anderson, and A.A. McNamara Spontaneous development of autoimmune uveitis is CCR2 dependent Am. J. Pathol. 184 2014 1695 1705
8. Y.J. Chen, M.Y. Hsieh, M.Y. Chang, H.C. Chen, M.S. Jan, M.C. Maa, and T.H. Leu Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages J. Biol. Chem. 287 2012 18806 18819
9. Q. Hou, X. Tang, H. Liu, J. Tang, Y. Yang, X. Jing, Q. Xiao, W. Wang, X. Gou, and Z. Wang Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147 Cancer Sci. 102 2011 1287 1292
10. C.Y. Hsiang, S.L. Wu, S.E. Cheng, and T.Y. Ho Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells J. Biomed. Sci. 12 2005 791 801
11. M.Y. Hsieh, M.Y. Chang, Y.J. Chen, Y.K. Li, T.H. Chuang, G.Y. Yu, C.H. Cheung, H.C. Chen, M.C. Maa, and T.H. Leu The inducible nitric-oxide synthase (iNOS)/Src axis mediates Toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon-beta synthesis in macrophages J. Biol. Chem. 289 2014 9208 9220
12. M. Ikram A review on the chemical and pharmacological aspects of genus Berberis Planta Med. 28 1975 353 358
13. M. Imanshahidi, and H. Hosseinzadeh Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine Phytother. Res. 22 2008 999 1012
14. T. Kaisho, and S. Akira Toll-like receptor function and signaling J. Allergy Clin. Immunol. 117 2006 979 987
15. T. Kawai, and S. Akira The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Nat. Immunol. 11 2010 373 384
16. T. Kawai, and S. Akira Toll-like receptors and their crosstalk with other innate receptors in infection and immunity Immunity 34 2011 637 650
17. W. Kong, J. Wei, P. Abidi, M. Lin, S. Inaba, C. Li, Y. Wang, Z. Wang, S. Si, H. Pan, S. Wang, J. Wu, Y. Wang, Z. Li, J. Liu, and J.D. Jiang Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins Nat. Med. 10 2004 1344 1351
18. C.W. Lau, X.Q. Yao, Z.Y. Chen, W.H. Ko, and Y. Huang Cardiovascular actions of berberine Cardiovasc. Drug. Rev. 19 2001 234 244
19. C.H. Lee, J.C. Chen, C.Y. Hsiang, S.L. Wu, H.C. Wu, and T.Y. Ho Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells Pharmacol. Res. 56 2007 193 201
20. T.H. Leu, and M.C. Maa Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397 Oncogene 21 2002 6992 7000
21. T.H. Leu, S. Charoenfuprasert, C.K. Yen, C.W. Fan, and M.C. Maa Lipopolysaccharide induced c-Src expression plays a role in nitric oxide and TNFa secretion in macrophages Mol. Immunol. 43 2006 308 316
22. Y. Liu, H. Yu, C. Zhang, Y. Cheng, L. Hu, X. Meng, and Y. Zhao Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer Eur. J. Cancer 44 2008 2425 2432
23. J. Losy Is MS an inflammatory or primary degenerative disease? J. Neural Transm. 120 2013 1459 1462
24. M.C. Maa, M.Y. Chang, Y.J. Chen, C.H. Lin, C.J. Yu, Y.L. Yang, J. Li, P.R. Chen, C.H. Tang, H.Y. Lei, and T.H. Leu Requirement of inducible nitric-oxide synthase in lipopolysaccharide-mediated Src induction and macrophage migration J. Biol. Chem. 283 2008 31408 31416
25. M.C. Maa, M.Y. Chang, J. Li, Y.Y. Li, M.Y. Hsieh, C.J. Yang, Y.J. Chen, Y. Li, H.C. Chen, W.E. Cheng, C.Y. Hsieh, C.W. Cheng, and T.H. Leu The iNOS/Src/FAK axis is critical in Toll-like receptor-mediated cell motility in macrophages Biochim. Biophys. Acta 1813 2011 136 147
26. M.C. Maa, J.R. Lai, R.W. Lin, and T.H. Leu Enhancement of tyrosyl phosphorylation and protein expression of eps8 by v-Src Biochim. Biophys. Acta 1450 1999 341 351
27. M.C. Maa, and T.H. Leu Vanadate-dependent FAK activation is accomplished by the sustained FAK Tyr-576/577 phosphorylation Biochem. Biophys. Res. Commun. 251 1998 344 349
28. M.C. Maa, and T.H. Leu Activation of Toll-like receptors induces macrophage migration via the iNOS/Src/FAK pathway BioMedicine 1 2011 11 15
29. A.F. McGettrick, and L.A. O'Neill Localisation and trafficking of Toll-like receptors: an important mode of regulation Curr. Opin. Immunol. 22 2010 20 27
30. C. Mo, L. Wang, J. Zhang, S. Numazawa, H. Tang, X. Tang, X. Han, J. Li, M. Yang, Z. Wang, D. Wei, and H. Xiao The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice Antioxid. Redox Signal. 20 2014 574 588
31. H. Park, D. Ishihara, and D. Cox Regulation of tyrosine phosphorylation in macrophage phagocytosis and chemotaxis Arch. Biochem. Biophys. 510 2011 101 111
32. J.T. Parsons Focal adhesion kinase: the first ten years J. Cell Sci. 116 2003 1409 1416
33. J.T. Parsons, K.H. Martin, J.K. Slack, J.M. Taylor, and S.A. Weed Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement Oncogene 19 2000 5606 5613
34. A. Poltorak, X. He, I. Smirnova, M.Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, and B. Beutler Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in tlr4 gene Science 282 1998 2085 2088
35. M.D. Schaller, J.D. Hildebrand, J.D. Shannon, J.W. Fox, R.R. Vines, and J.T. Parsons Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2- dependent binding of pp60src Mol. Cell. Biol. 14 1994 1680 1688
36. S. Shi, C. Nathan, D. Schnappinger, J. Drenkow, M. Fuortes, E. Block, A. Ding, T.R. Gingeras, G. Schoolnik, S. Akira, K. Takeda, and S. Ehrt MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis J. Exp. Med. 198 2003 987 997
37. T. Singh, M. Vaid, N. Katiyar, S. Sharma, and S.K. Katiyar Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E(2) and prostaglandin E(2) receptors Carcinogenesis 32 2011 86 92
38. Y. Sun, K. Xun, Y. Wang, and X. Chen A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs Anticancer Drugs 20 2009 757 769
39. T. Tanno, A. Fujiwara, K. Sakaguchi, K. Tanaka, S. Takenaka, and S. Tsuyama Slit3 regulates cell motility through Rac/Cdc42 activation in lipopolysaccharide-stimulated macrophages FEBS Lett. 581 2007 1022 1026
40. - microparticles is associated with improvement of endothelial function in humans Eur. J. Pharmacol. 614 2009 77 783
41. K.J. Woollard Immunological aspects of atherosclerosis Clin. Sci. 125 2013 221 235
42. C.M. Wu, T.M. Li, T.W. Tan, Y.C. Fong, and C.H. Tang Berberine reduces the metastasis of chondrosarcoma by modulating the αvβ3 integrin and the PKCδ, c-Src, and AP-1 signaling pathways Evid. Based Complement. Altern. Med. 2013 2013 423164
43. S. You, S.A. Yoo, S. Choi, J.Y. Kim, S.J. Park, J.D. Ji, K.J. Kim, C.S. Cho, D. Hwang, and W.u. Kim Identification of key regulators for the migration and invasion of rheumatoid synoviocytes through a systems approach Proc. Natl. Acad. Sci. U. S. A. 111 2014 550 555
44. W. Zhou, and S. Bao Reciprocal supportive interplay between glioblastoma and tumor-associated macrophages Cancers (Basel) 6 2014 723 740
45. D. Zicha, W.E. Allen, P.M. Brickell, C. Kinnon, G.A. Dunn, G.E. Jones, and A.J. Thrasher Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome Br. J. Haematol. 101 1998 659 665