Age-related changes in the diurnal variation of ketogenesis in patients with type 2 diabetes and relevance to hypoglycemic medications

Endocrine Journal

Volumn 62, Issue 3, 2015, Pages 235-241

  Nakayama, Hitomi ^a   Tokubuchi, Ichiro ^a   Wada, Nobuhiko ^a   Tsuruta, Munehisa ^a   Ohki, Tsuyoshi ^a   Oshige, Tamami ^a   Sasaki, Yuko ^a   Iwata, Shinpei ^a   Kato, Naoka ^a   Ohtsuka, Yoshie ^a   Matsuo, Yuko ^a   Tajiri, Yuji ^a   Yamada, Kentaro ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

3 hydroxybutyrate; Aging; Diurnal variation; Free fatty acid; Ketosis

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; FATTY ACID; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; INSULIN; METFORMIN; PIOGLITAZONE; SULFONYLUREA; GLUCOSE BLOOD LEVEL; KETONE BODY;

ADULT; AGED; AGING; ARTICLE; BLOOD SAMPLING; BRAIN; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENERGY RESOURCE; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; KETOACIDOSIS; KETOGENESIS; LOW FAT DIET; MAJOR CLINICAL STUDY; MALE; MEAL; NON INSULIN DEPENDENT DIABETES MELLITUS; STARVATION; AGE; BLOOD; DIABETES MELLITUS, TYPE 2; MIDDLE AGED; PHYSIOLOGY;

AGE FACTORS; AGED; BLOOD GLUCOSE; CIRCADIAN RHYTHM; DIABETES MELLITUS, TYPE 2; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; KETONE BODIES; MALE; MIDDLE AGED;

EID: 84926155800     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ14-0431     Document Type: Article

References (33)

1. Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M (2004) Foxa2 regulates lipid metabolism and ketogen-esis in the liver during fasting and in diabetes. Nature 432: 1027-1032.
2. von Meyenn F, Porstmann T, Gasser E, Selevsek N, Schmidt A, et al. (2013) Glucagon-induced acetyla-tion of Foxa2 regulates hepatic lipid metabolism. Cell Metab 17: 436-447.
3. Tildon JT, Roeder LM (1988) Transport of 3-hydroxy[3-14C]butyrate by dissociated cells from rat brain. Am J Physiol 255: C133-139.
4. Vining EP, Freeman JM, Ballaban-Gil K, Camfeld CS, Camfeld PR, et al. (1998) A multicenter study of the effcacy of the ketogenic diet. Arch Neurol 55: 1433-1437.
5. Stafstrom CE (2004) Dietary approaches to epilepsy treatment: old and new options on the menu. Epilepsy Curr 4: 215-222.
6. Sinha SR, Kossoff EH (2005) The ketogenic diet. Neurologist 11: 161-170.
7. Cervenka MC, Henry B, Nathan J, Wood S, Volek JS (2013) Worldwide dietary therapies for adults with epilepsy and other disorders. J Child Neurol 28: 1034-1040.
8. Rho JM, Anderson GD, Donevan SD, White HS (2002) Acetoacetate, acetone, and dibenzylamine (a contaminant in l-(+)-beta-hydroxybutyrate) exhibit direct anti-convulsant actions in vivo. Epilepsia 43: 358-361.
9. Puchowicz MA, Zechel JL, Valerio J, Emancipator DS, Xu K, et al. (2008) Neuroprotection in diet-induced ketotic rat brain after focal ischemia. J Cereb Blood Flow Metab 28: 1907-1916.
10. Krikorian R, Shidler MD, Dangelo K, Couch SC, Benoit SC, et al. (2010) Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging 33: 425. e19-e27.
11. Van der Auwera I, Wera S, Van Leuven F, Henderson ST (2005) A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease. Nutr Metab (Lond) 2: 28.
12. Ubukata E (1990) Diurnal variation of blood ketone bodies in insulin-dependent diabetes mellitus and non-insulin-dependent diabetes mellitus patients: the relationship to serum C-peptide immunoreactivity and free insulin. Ann Nutr Metab 34: 333-342.
13. Dinneen S, Alzaid A, Miles J, Rizza R (1995) Effects of the normal nocturnal rise in cortisol on carbohydrate and fat metabolism in IDDM. Am J Physiol 268: E595-603.
14. American Diabetes Association (2010) Standards of Medical Care in Diabetes - 2010. Diabetes Care 33 Supple 1: S11-61.
15. Committee of the Japan Diabetes Society on theDiagnostic Criteria of Diabetes Mellitus, Seino Y, Nanjo K, Tajima N, Kadowaki T, Kashiwagi A, et al. (2010) Report of the committee on the classifcation and diagnostic criteria of diabetes mellitus. J Diabetes Investig 1: 212-228.
16. Ho JE, Larson MG, Vasan RS, Ghorbani A, Cheng S, et al. (2013) Metabolite profles during oral glucose challenge. Diabetes 62: 2689-2698.
17. Kryshak EJ, Butler PC, Marsh C, Miller A, Barr D, et al. (1990) Pattern of postprandial carbohydrate metabolism and effects of portal and peripheral insulin delivery. Diabetes 39: 142-148.
18. Daly LP, Osterhoudt KC, Weinzimer SA (2003) Presenting features of idiopathic ketotic hypoglycemia. J Emerg Med 25: 39-43.
19. Okuda Y, Kawai K, Yamashita K (1987) Age-related change in ketone body metabolism: diminished gluca-gon effect on ketogenesis in adult rats. Endocrinology 120: 2152-2157.
20. Sastre J, Pallardó F V, Plá R, Pellín A, Juan G, et al. (1996) Aging of the liver: age-associated mitochondrial damage in intact hepatocytes. Hepatology 24: 1199-1205.
21. Shilo L, Chin JH, Hoffman BB (1994) Impaired beta-ad-renergic receptor-mediated regulation of gene expression in adipocytes from older rats. Am J Physiol 266: E659-665.
22. Faintrenie G, Géloën A (1997) Effect of aging on nor-epinephrine and phenylephrine stimulated lactate production by white adipocytes. Obes Res 5: 100-104.
23. Yamada K, Nonaka K (1996) Diabetic ketoacidosis in young obese Japanese men. Diabetes Care 19: 671.
24. White H, Venkatesh B (2011) Clinical review: Ketones and brain injury. Crit Care 15: 219.
25. Prins ML (2008) Cerebral metabolic adaptation and ketone metabolism after brain injury. J Cereb Blood Flow Metab 28: 1-16.
26. Yamada KA, Rensing N, Thio LL (2005) Ketogenic diet reduces hypoglycemia-induced neuronal death in young rats. Neurosci Lett 385: 210-214.
27. Haces ML, Hernández-Fonseca K, Medina-Campos ON, Montiel T, Pedraza-Chaverri J, et al. (2008) Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypo-glycemic conditions. Exp Neurol 211: 85-96.
28. Wang S, Soni KG, Semache M, Casavant S, Fortier M, et al. (2008) Lipolysis and the integrated physiology of lipid energy metabolism. Mol Genet Metab 95: 117-126.
29. Carmen GY, Víctor SM (2006) Signalling mechanisms regulating lipolysis. Cell Signal 18: 401-408.
30. Unger RH (1978) Role of glucagon in the pathogenesis of diabetes: the status of the controversy. Metabolism 27: 1691-1709.
31. Avogaro A 1, Valerio A, Gnudi L, Maran A, Zolli M, et al. (1992) Ketone body metabolism in NIDDM. Effect of sulfonylurea treatment. Diabetes 41: 968-974.
32. Sönksen PH, Lowy C, Perkins JR, Lim HS (1984) Non-insulin-dependent diabetes: 10-year outcome in relation to initial response to diet and subsequent sulfonylurea therapy. Diabetes Care 7 Suppl 1: 59-66.
33. Devenny JJ, Godonis HE, Harvey SJ, Rooney S, Cullen MJ, et al. (2012) Weight loss induced by chronic dapaglifozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats. Obesity (Silver Spring) 20: 1645-1652.