FBXL5 inhibits metastasis of gastric cancer through suppressing Snail1

Cellular Physiology and Biochemistry

Volumn 35, Issue 5, 2015, Pages 1764-1772

  Wu, Weidong ^a   Ding, Honghua ^a   Cao, Jun ^a   Zhang, Weihao ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Cancer invasion; FBXL5; Gastric cancer; Metastasis; Snail1

Indexed keywords

F BOX PROTEIN; FBXL5 PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SNAIL1; UNCLASSIFIED DRUG; FBXL5 PROTEIN, HUMAN; PROTEIN BINDING; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CANCER CELL; CANCER GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; METASTASIS; PLASMID; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; STOMACH CANCER; UBIQUITINATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL MOTION; CHEMISTRY; EPITHELIAL MESENCHYMAL TRANSITION; GENETICS; METABOLISM; PATHOLOGY; RNA INTERFERENCE; STOMACH TUMOR; TUMOR CELL LINE;

GASTROPODA;

CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; F-BOX PROTEINS; HUMANS; IMMUNOPRECIPITATION; NEOPLASM METASTASIS; PROTEIN BINDING; RNA INTERFERENCE; RNA, SMALL INTERFERING; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84926155328     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000373988     Document Type: Article

References (33)

1. Zhao X, Li X, Yuan H: Micrornas in gastric cancer invasion and metastasis. Front Biosci 2013;18:803-810.
2. Liu G, Jiang C, Li D, Wang R, Wang W: Mirna-34a inhibits egfr-signaling-dependent mmp7 activation in gastric cancer. Tumour Biol 2014;35:9801-9806.
3. Mao D, Zhang Y, Lu H, Zhang H: Molecular basis underlying inhibition of metastasis of gastric cancer by anti-vegfa treatment. Tumour Biol 2014;35:8217-8223.
4. Ye Y, Zhou X, Li X, Tang Y, Sun Y, Fang J: Inhibition of epidermal growth factor receptor signaling prohibits metastasis of gastric cancer via downregulation of mmp7 and mmp13. Tumour Biol 2014;35:10891-10896.
5. Shang Y, Cai X, Fan D: Roles of epithelial-mesenchymal transition in cancer drug resistance. Curr Cancer Drug Targets 2013;13:915-929.
6. Kiesslich T, Pichler M, Neureiter D: Epigenetic control of epithelial-mesenchymal-transition in human cancer. Mol Clin Oncol 2013;1:3-11.
7. Meng F, Wu G: The rejuvenated scenario of epithelial-mesenchymal transition (emt) and cancer metastasis. Cancer Metastasis Rev 2012;31:455-467.
8. Leroy P, Mostov KE: Slug is required for cell survival during partial epithelial-mesenchymal transition of hgf-induced tubulogenesis. Mol Biol Cell 2007;18:1943-1952.
9. Lamorte L, Royal I, Naujokas M, Park M: Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for hgf-mediated cell spreading and breakdown of epithelial adherens junctions. Mol Biol Cell 2002;13:1449-1461.
10. Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, Song Z, El-Gohary Y, Prasadan K, Shiota C, Gittes GK: M2 macrophages promote beta-cell proliferation by up-regulation of smad7. Proc Natl Acad Sci U S A 2014;111:E1211-1220.
11. Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ: An autocrine tgf-beta/zeb/mir-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell 2011;22:1686-1698.
12. Valcourt U, Kowanetz M, Niimi H, Heldin CH, Moustakas A: Tgf-beta and the smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell 2005;16:1987-2002.
13. Muthusami S, Prabakaran DS, Yu JR, Park WY: Egf-induced expression of fused toes homolog (fts) facilitates epithelial-mesenchymal transition and promotes cell migration in me180 cervical cancer cells. Cancer Lett 2014;351:252-259.
14. Sakuma K, Aoki M, Kannagi R: Transcription factors c-myc and cdx2 mediate e-selectin ligand expression in colon cancer cells undergoing egf/bfgf-induced epithelial-mesenchymal transition. Proc Natl Acad Sci U S A 2012;109:7776-7781.
15. Shirakihara T, Horiguchi K, Miyazawa K, Ehata S, Shibata T, Morita I, Miyazono K, Saitoh M: Tgf-beta regulates isoform switching of fgf receptors and epithelial-mesenchymal transition. EMBO J 2011;30:783-795.
16. Ramos C, Becerril C, Montano M, Garcia-De-Alba C, Ramirez R, Checa M, Pardo A, Selman M: Fgf-1 reverts epithelial-mesenchymal transition induced by tgf-{beta}1 through mapk/erk kinase pathway. Am J Physiol Lung Cell Mol Physiol 2010;299:L222-231.
17. Billottet C, Tuefferd M, Gentien D, Rapinat A, Thiery JP, Broet P, Jouanneau J: Modulation of several waves of gene expression during fgf-1 induced epithelial-mesenchymal transition of carcinoma cells. J Cell Biochem 2008;104:826-839.
18. Yang N, Hui L, Wang Y, Yang H, Jiang X: Overexpression of sox2 promotes migration, invasion, and epithelial-mesenchymal transition through the wnt/beta-catenin pathway in laryngeal cancer hep-2 cells. Tumour Biol 2014;35:7965-7973.
19. Huang J, Xiao D, Li G, Ma J, Chen P, Yuan W, Hou F, Ge J, Zhong M, Tang Y, Xia X, Chen Z: Epha2 promotes epithelial-mesenchymal transition through the wnt/beta-catenin pathway in gastric cancer cells. Oncogene 2014;33:2737-2747.
20. Kaufhold S, Bonavida B: Central role of snail1 in the regulation of emt and resistance in cancer: A target for therapeutic intervention. J Exp Clin Cancer Res 2014;33:62.
21. Franco DL, Mainez J, Vega S, Sancho P, Murillo MM, de Frutos CA, Del Castillo G, Lopez-Blau C, Fabregat I, Nieto MA: Snail1 suppresses tgf-beta-induced apoptosis and is sufficient to trigger emt in hepatocytes. J Cell Sci 2010;123:3467-3477.
22. Zheng H, Shen M, Zha YL, Li W, Wei Y, Blanco MA, Ren G, Zhou T, Storz P, Wang HY, Kang Y: Pkd1 phosphorylation-dependent degradation of snail by scf-fbxo11 regulates epithelial-mesenchymal transition and metastasis. Cancer Cell 2014;26:358-373.
23. Moroishi T, Yamauchi T, Nishiyama M, Nakayama KI: Herc2 targets the iron regulator fbxl5 for degradation and modulates iron metabolism. J Biol Chem 2014;289:16430-16441.
24. Ruiz JC, Bruick RK: F-box and leucine-rich repeat protein 5 (fbxl5): Sensing intracellular iron and oxygen. J Inorg Biochem 2014;133:73-77.
25. Ruiz JC, Walker SD, Anderson SA, Eisenstein RS, Bruick RK: F-box and leucine-rich repeat protein 5 (fbxl5) is required for maintenance of cellular and systemic iron homeostasis. J Biol Chem 2013;288:552-560.
26. Chollangi S, Thompson JW, Ruiz JC, Gardner KH, Bruick RK: Hemerythrin-like domain within f-box and leucine-rich repeat protein 5 (fbxl5) communicates cellular iron and oxygen availability by distinct mechanisms. J Biol Chem 2012;287:23710-23717.
27. Shu C, Sung MW, Stewart MD, Igumenova TI, Tan X, Li P: The structural basis of iron sensing by the human f-box protein fbxl5. Chembiochem 2012;13:788-791.
28. Thompson JW, Salahudeen AA, Chollangi S, Ruiz JC, Brautigam CA, Makris TM, Lipscomb JD, Tomchick DR, Bruick RK: Structural and molecular characterization of iron-sensing hemerythrin-like domain within f-box and leucine-rich repeat protein 5 (fbxl5). J Biol Chem 2012;287:7357-7365.
29. Moroishi T, Nishiyama M, Takeda Y, Iwai K, Nakayama KI: The fbxl5-irp2 axis is integral to control of iron metabolism in vivo. Cell Metab 2011;14:339-351.
30. Vinas-Castells R, Frias A, Robles-Lanuza E, Zhang K, Longmore GD, Garcia de Herreros A, Diaz VM: Nuclear ubiquitination by fbxl5 modulates snail1 DNA binding and stability. Nucleic Acids Res 2014;42:1079-1094.
31. Cen G, Ding HH, Liu B, Wu WD: Fbxl5 targets cortactin for ubiquitination-mediated destruction to regulate gastric cancer cell migration. Tumour Biol 2014;35:8633-8638.
32. Liang CC, Park AY, Guan JL: In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2007;2:329-333.
33. Lee MS, Kim S, Kim BG, Won C, Nam SH, Kang S, Kim HJ, Kang M, Ryu J, Song HE, Lee D, Ye SK, Jeon NL, Kim TY, Cho NH, Lee JW: Snail1 induced in breast cancer cells in 3d collagen i gel environment suppresses cortactin and impairs effective invadopodia formation. Biochim Biophys Acta 2014;1843:2037-2054.