MiRNA-34a inhibits EGFR-signaling-dependent MMP7 activation in gastric cancer

Tumor Biology

Volumn 35, Issue 10, 2014, Pages 9801-9806

  Liu, Gang ^a   Jiang, Chuanshen ^a   Li, Dazhou ^a   Wang, Rong ^a   Wang, Wen ^a  

^a FUZHOU GENERAL HOSPITAL   (China)

Author keywords

Akt; Epidermal growth factor receptor; Gastric cancer; MiRNA 34a; MMP7; Phosphatidylinositol 3 kinase

Indexed keywords

EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; MATRILYSIN; MICRORNA; MMP7 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ADENOCARCINOMA; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STOMACH TUMOR; TUMOR CELL LINE; TUMOR INVASION; WESTERN BLOTTING;

ADENOCARCINOMA; BLOTTING, WESTERN; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MATRIX METALLOPROTEINASE 7; MICRORNAS; NEOPLASM INVASIVENESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

EID: 84922395100     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1007/s13277-014-2273-6     Document Type: Article

References (16)

1. Zhao X, Li X, Yuan H. MicroRNAs in gastric cancer invasion and metastasis. Front Biosci. 2013; 18: 803-10.
2. Cardoso AP, Pinto ML, Pinto AT, Oliveira MI, Pinto MT, Goncalves R, et al. Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity. Oncogene. 2014; 33: 2123-33.
3. Hotz B, Keilholz U, Fusi A, Buhr HJ, Hotz HG. In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype. Gastric Cancer Off J Int Gastric Cancer Assoc Jpn Gastric Cancer Assoc. 2012; 15: 252-64.
4. Kim JW, Kim HP, Im SA, Kang S, Hur HS, Yoon YK, et al. The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines. Cancer Lett. 2008; 272: 296-306.
5. Kim S, Choi JH, Lim HI, Lee SK, Kim WW, Cho S, et al. EGFinducedMMP-9 expression is mediated by the JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line. Cell Signal. 2009; 21: 892-8.
6. SchneiderMR, Wolf E. The epidermal growth factor receptor ligands at a glance. J Cell Physiol. 2009; 218: 460-6.
7. Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, et al. M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7. Proc Natl Acad Sci U S A. 2014; 111: E1211-20.
8. Li Z, Zhang D, Zhang H, Miao Z, Tang Y, Sun G, et al. Prediction of peritoneal recurrence by the mRNA level of CEA and MMP-7 in peritoneal lavage of gastric cancer patients. Tumour Biol. 2014; 35: 3463-70.
9. Shi M, Liu D, Duan H, Han C, Wei B, Qian L, et al. Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer. Mol Cancer. 2010; 9: 269.
10. Koskensalo S, Mrena J, Wiksten JP, Nordling S, Kokkola A, Hagstrom J, et al. MMP-7 overexpression is an independent prognostic marker in gastric cancer. Tumour Biol. 2010; 31: 149-55.
11. Zhao C, Bu X, Zhang N, Wang W. Downregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer. BMC Cancer. 2009; 9: 224.
12. Di Leva G, Croce CM. MiRNA profiling of cancer. Curr Opin Genet Dev. 2013; 23: 3-11.
13. Pereira DM, Rodrigues PM, Borralho PM, Rodrigues CM. Delivering the promise of miRNA cancer therapeutics. Drug Discov Today. 2013; 18: 282-9.
14. Peng Y, Guo JJ, Liu YM, Wu XL. MicroRNA-34a inhibits the growth, invasion and metastasis of gastric cancer by targeting PDGFR and met expression. Biosci Rep. 2014.
15. Cao W, Yang W, Fan R, Li H, Jiang J, Geng M, et al. Mir-34a regulates cisplatin-induce gastric cancer cell death by modulating PI3K/AKT/survivin pathway. Tumour Biol. 2014; 35: 1287-95.
16. CaoW, Fan R, Wang L, Cheng S, Li H, Jiang J, et al. Expression and regulatory function of miRNA-34a in targeting survivin in gastric cancer cells. Tumour Biol. 2013; 34: 963-71.