Translational research on Barrett's esophagus

Annals of the New York Academy of Sciences

Volumn 1325, Issue 1, 2014, Pages 170-186

  Baruah, Anushka ^a   Buttar, Navtej ^a   Chandra, Raghav ^a   Chen, Xiaoxin ^b,c   Clemons, Nicholas J ^d,e   Compare, Debora ^f   El Rifai, Wael ^g   Gu, Jian ^h   Houchen, Courtney W ⁱ   Koh, Shze Yung ^d,e   Li, Wenbo ^b,j   Nardone, Gerardo ^f   Phillips, Wayne A ^d,e   Sharma, Anamay ^a   Singh, Ishtpreet ^a   Upton, Melissa P ^k   Vega, Kenneth J ⁱ   Wu, Xifeng ^h  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^b NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d PETER MACCALLUM CANCER CENTRE   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^g VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^h UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

ⁱ UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^j JINAN MILITARY GENERAL HOSPITAL   (China)

^k UNIVERSITY OF WASHINGTON   (United States)

more..

Author keywords

Barrett's esophagus; DCLK; Esophageal adenocarcinoma; Microsatellite instability; Modeling; OESO; Oxidative stress

Indexed keywords

ANTIOXIDANT; DOUBLECORTIN; DOUBLECORTIN LIKE KINASE 1; PROTEIN P63; PROTEINASE ACTIVATED RECEPTOR; TRANSCRIPTION FACTOR CDX2; TUMOR MARKER; UNCLASSIFIED DRUG; MICROSATELLITE DNA;

ARTICLE; BARRETT ESOPHAGUS; BLOOD; CANCER MODEL; CANCER RESEARCH; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; DISEASE COURSE; EPIGENETICS; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS CANCER; GENE OVEREXPRESSION; GENETIC VARIABILITY; GENOMIC INSTABILITY; GERMLINE MUTATION; HISTOPATHOLOGY; HUMAN; IN VIVO STUDY; METAPLASIA; MICROSATELLITE INSTABILITY; MOLECULAR PATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PREDICTION; REGENERATIVE MEDICINE; SOMATIC MUTATION; TISSUE REGENERATION; TRANSCRIPTION REGULATION; TRANSLATIONAL RESEARCH; ANIMAL; FRANCE; GENETICS; PROCEDURES; TRENDS;

ANIMALS; BARRETT ESOPHAGUS; DISEASE PROGRESSION; HUMANS; MICROSATELLITE REPEATS; OXIDATIVE STRESS; PARIS; TRANSLATIONAL MEDICAL RESEARCH; TUMOR MARKERS, BIOLOGICAL;

EID: 84926115200     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12531     Document Type: Article

References (71)

1. Bhat, S., H.G. Coleman, F. Yousef, et al. 2011. Risk of malignant progression in Barrett's esophagus patients: results from a large population-based study. J. Natl. Cancer Inst. 103: 1049-1057.
2. Gu, J., J.A. Ajani, E.T. Hawk, et al. 2010. Genome-wide catalogue of chromosomal aberrations in Barrett's esophagus and esophageal adenocarcinoma: a high-density single nucleotide polymorphism array analysis. Cancer Prev. Res. 3: 1176-1186.
3. Agrawal, N., Y. Jiao, C. Bettegowda, et al. 2012. Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. Cancer Discov. 2: 899-905.
4. Xu, E., J. Gu, E.T. Hawk, et al. 2013. Genome-wide methylation analysis shows similar patterns in Barrett's esophagus and esophageal adenocarcinoma. Carcinogenesis 34: 2750-2756.
5. Wu, X., J.A. Ajani, J. Gu, et al. 2013. MicroRNA expression signatures during malignant progression from Barrett's esophagus to esophageal adenocarcinoma. Cancer Prev. Res. 6: 196-205.
6. Levine, D.M., W.E. Ek, R. Zhang, et al. 2013. A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. Nat. Genet. 45: 1487-1493.
7. Xu, E., Y. Gong, J. Gu, et al. 2013. Risk assessment of esophageal adenocarcinoma using gamma-H2AX assay. Cancer Epidemiol Biomarkers Prev. 22: 1797-1804.
8. Risques, R.A., T.L. Vaughan, X. Li, et al. 2007. Leukocyte telomere length predicts cancer risk in Barrett's esophagus. Cancer Epidemiol Biomarkers Prev. 16: 2649-2655.
9. Xing, J., J.A. Ajani, M. Chen, et al. 2009. Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer. Cancer Prev. Res. 2: 459-465.
10. Xu, E., W. Sun, J. Gu, et al. 2013. Association of mitochondrial DNA copy number in peripheral blood leukocytes with risk of esophageal adenocarcinoma. Carcinogenesis 34: 2521-2524.
11. Paulson, T.G. & B.J. Reid . 2004. Focus on Barrett's esophagus and esophageal adenocarcinoma. Cancer Cell 6: 11-16.
12. Sato, F. & S.J. Meltzer . 2006. CPG island hypermethylation in progression of esophageal and gastric cancer. Cancer 106: 483-493.
13. Shiraishi, H., T. Mikami, J. Aida, et al. 2009. Telomere shortening in Barrett's mucosa and adenocarcinoma and its association with loss of heterozygosity. Scand. J. Gastroenterol. 44: 538-544.
14. Yanagi, M., G. Keller, J. Mueller, et al. 2000. Comparison of loss of heterozygosity and microsatellite instability in adenocarcinomas of distal esophagus and proximal stomach. Virchows Arch. 437: 605-610.
15. Farris, A.B., E.G. Demicco, L.P. Le, et al. 2011. Clinicopathologic and molecular profiles of microsatellite unstable Barrett esophagus-associated adenocarcinoma. Am. J. Surg. Path. 35: 647-655.
16. Ronkainen, J., P. Aro, T. Storskrubb, et al. 2005. Prevalence of Barrett's esophagus in the general population: an endoscopic study. Gastroenterology 129: 1825-1831.
17. Wang, J.S. & M.I. Canto . 2010. Predicting neoplastic progression in Barrett's esophagus. Ann. Gastroenterol. Hepatol. 1: 1-10.
18. Corley, D.A., K. Methani, C. Quesenberry, et al. 2013. Impact of endoscopic surveillance on Mortality of Barrett's esophagus-associated esophageal adenocarcinomas. Gastroenterology 145: 312-319.
19. Shaheen, N.J. & C. Hur . 2013. Garlic, silver bullets and surveillance endoscopy for Barrett's esophagus. Gastroenterology 145: 273-276.
20. Fels Elloitt, D.R. & R.C. Fitzgerald . 2013. Molecular markers for Barrett's esophagus and its progression to cancer. Curr. Opin. Gastroenterol. 29: 437-445.
21. May, R., T.E. Riehl, C. Hunt, et al. 2008. Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, double cortin and CaM kinase like-1, following radiation injury and in adenomatous polyposis coli/ multiple intestinal neoplasia mice. Stem Cells 26: 630-637.
22. May, R., S.M. Sureban, N. Hoang, et al. 2009. Doublecortin and CaM kinase like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells respectively. Stem Cells 27: 2571-2579.
23. Nakanishi, Y., H. Seno, A. Fukuoka, et al. 2012. DCLK1 distinguishes between tumor and normal stem cells in the intestine. Nat. Genet. 45: 98-103.
24. Vega, K.J., R. May, S.M. Sureban, et al. 2012. Identification of the putative intestinal stem cell marker doublecortin and CaM kinase like-1 in Barrett's esophagus and esophageal adenocarcinoma. J. Gastroenterol. Hepatol. 27: 773-780.
25. Panayiotidis, M. 2008. Reactive oxygen species (ROS) in multistage carcinogenesis. Cancer Lett. 266: 3-5.
26. Droge, W. 2002. Free radicals in the physiological control of cell function. Physiol. Rev. 82: 47-95.
27. Farhadi, A., J. Fields, A. Banan & A. Keshavarzian . 2002. Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus, and the latter's progression toward esophageal cancer? Am. J. Gastroenterol. 97: 22-26.
28. Chen, X., Y.W. Ding, G. Yang, et al. 2000. Oxidative damage in an esophageal adenocarcinoma model with rats. Carcinogenesis 21: 257-263.
29. Dvorak, K., C.M. Payne, M. Chavarria, et al. 2007. Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus. Gut 56: 763-771.
30. Peng, D., A. Belkhiri, T. Hu, et al. 2012. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut 61: 1250-1260.
31. Miyamoto, Y., Y.H. Koh, Y.S. Park, et al. 2003. Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses. Biol. Chem. 384: 567-574.
32. Salinas, A.E. & M.G. Wong . 1999. Glutathione S-transferases: a review. Curr. Med. Chem. 6: 279-309.
33. van Lieshout, E.M., D.M. Tiemessen, B.J. Witteman, et al. 1999. Low glutathione and glutathione S-transferase levels in Barrett's esophagus as compared to normal esophageal epithelium. Jpn. J. Cancer Res. 90: 81-85.
34. Peng, D.F., M. Razvi, H. Chen, et al. 2009. DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. Gut 58: 5-15.
35. Peng, D., T. Hu, M. Soutto, et al. 2014. Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma. Gut 63: 540-551.
36. De Hertogh, G., N. Ectors, P. Van Eyken & K. Geboes . 2006. Review article: the nature of oesophageal injury in gastro-oesophageal reflux disease. Aliment. Pharmacol. Ther. 24: 17-26.
37. Hollenberg, M.D. 2010. Getting the message across: pathophysiology and signaling via receptors for polypeptide hormones and proteinases. Clin. Invest. Med. 33: E133.
38. Ramachandran, R. & M.D. Hollenberg . 2008. Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br. J. Pharmacol. 153: S263-S282.
39. Soh, U.J., M.R. Dores, B. Chen & J. Trejo . 2010. Signal transduction by protease-activated receptors. Br. J. Pharmacol. 160: 191-203.
40. Kawabata, A., M. Matsunami & F. Sekiguchi . 2008. Gastrointestinal roles for proteinase-activated receptors in health and disease. Br. J. Pharmacol. 153: S230-S240.
41. Inci, K., A. Edebo, L. Olbe & A. Casselbrant . 2009. Expression of protease-activated-receptor 2 (PAR-2) in human esophageal mucosa. Scand. J. Gastroenterol. 44: 664-671.
42. Kandulski, A., T. Wex, K. Monkemuller, et al. 2010. Proteinase-activated receptor-2 in the pathogenesis of gastroesophageal reflux disease. Am. J. Gastroenterol. 105: 1934-1943.
43. Shan, J., T. Oshima, X. Chen, et al. 2012. Trypsin impaired epithelial barrier function and induced IL-8 secretion through basolateral PAR-2: a lesson from a stratified squamous epithelial model. Am. J. Physiol. Gastrointest. Liver Physiol. 303: G1105-1112.
44. Yoshida, N., K. Katada, O. Handa, et al. 2007. Interleukin-8 production via protease-activated receptor 2 in human esophageal epithelial cells. Int. J. Mol. Med. 19: 335-340.
45. Seymour, M.L., D.G. Binion, S.J. Compton, et al. 2005. Expression of proteinase-activated receptor 2 on human primary gastrointestinal myofibroblasts and stimulation of prostaglandin synthesis. Can. J. Physiol. Pharmacol. 83: 605-616.
46. Hu, B., H. Chen, X. Liu, et al. 2013. Transgenic overexpression of cdx1b induces metaplastic changes of gene expression in zebrafish esophageal squamous epithelium. Zebrafish 10: 218-227.
47. Kong, J., M.A. Crissey, S. Funakoshi, et al. 2011. Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett's esophagus. PLoS One 6: e18280.
48. Quante, M., G. Bhagat, J.A. Abrams, et al. 2012. Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia. Cancer Cell 21: 36-51.
49. Wang, X., H. Ouyang, Y. Yamamoto, et al. 2011. Residual embryonic cells as precursors of a Barrett's-like metaplasia. Cell 145: 1023-1035.
50. Milano, F., J.W. van Baal, N.S. Buttar, et al. 2007. Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells. Gastroenterology 132: 2412-2421.
51. Parikh, K., D. Straub, A. Pacha, et al. 2012. Bone morphogenetic protein 4 (BMP4) overexpression in the squamous epithelium of mice oesophagi leads to the development of non-specialized columnar epithelium (NSCE). Presented at 11th OESO World Conference, Como, Italy, September 1 to 4, 2012.
52. Rodriguez, P., S. Da Silva, L. Oxburgh, et al. 2010. BMP signaling in the development of the mouse esophagus and forestomach. Development 137: 4171-4176.
53. Chen, H., Y. Fang, W. Tevebaugh, et al. 2011. Molecular mechanisms of Barrett's esophagus. Dig. Dis. Sci. 56: 3405-3420.
54. Szot, G.L., P. Koudria & J.A. Bluestone . 2007. Transplantation of pancreatic islets into the kidney capsule of diabetic mice. J. Vis. Exp. 9: 404.
55. Crissey, M.A., R.J. Guo, S. Funakoshi, et al. 2011. Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development. Gastroenterology 140: 517-528 e518.
56. Buttar, N.S. & K.K. Wang . 2004. Mechanisms of disease: Carcinogenesis in Barrett's esophagus. Nat. Clin. Pract. Gastroenterol. Hepatol. 1: 106-112.
57. Schuster-Böckler, B. & B. Lehner . 2012. Chromatin organization is a major influence on regional mutation rates in human cancer cells. Nature 488: 504-507.
58. Agarwal, A., R. Polineni & Z. Hussein . 2012. Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma. Int. J. Clin. Exp. Pathol. 5: 382-396.
59. Alvarez, H., J. Opalinska, L. Zhou, et al. 2011. Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis. PLoS Genet 7: e1001356.
60. Jin, Z., Y.L. Cheng, A. Olaru, et al. 2008. Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors. Int. J. Cancer 123: 2331-2336.
61. Kaz, A.M. & W.M. Grady . 2014. Epigenetic biomarkers in esophageal cancer. Cancer Lett. 342: 193-199.
62. Buttar, N.S., C.J. DeMars, G. Lomberk, et al. 2010. Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin e 2 biosynthesis. J. Biol. Chem. 285: 11433-11444.
63. Seder, C.W., W. Hartojo, L. Lin, et al. 2009. INHBA overexpression promotes cell proliferation and may be epigenetically regulated in esophageal adenocarcinoma. J. Thorac. Oncol. 4: 455-462.
64. Orlando, R.C. 2010. The integrity of the esophageal mucosa. Balance between offensive and defensive mechanisms. Best Pract. Res. Clin. Gastroenterol. 24: 873-882.
65. Burke, Z.D. & D. Tosh . 2012. Barrett's metaplasia as a paradigm for understanding the development of cancer. Curr. Opin. Genet. Dev. 22: 494-499.
66. von Holzen, U. & G.H. Enders . 2012. A surprise cell of origin for Barrett's esophagus. Cancer Biol Ther. 13: 588-591.
67. Dvorak, K., A. Goldman, J. Kong, et al. 2011. Molecular mechanisms of Barrett's esophagus and adenocarcinoma. Ann. N. Y. Acad. Sci. 1232: 381-391.
68. Souza, R.F., K. Krishnan & S.J. Spechler . 2008. Acid, bile and CDX: the ABCs of making Barrett's metaplasia. Am. J. Physiol. Gastrointest. Liver Physiol. 295: 211-218.
69. Sarosi, G., G. Brown, K. Jaiswal, et al. 2008. Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus. Dis. Esophagus. 21: 43-50.
70. Orlando, G., J.D. Bendala, T. Shupe, et al. 2013. Cell and organ bioengineering technology as applied to gastrointestinal diseases. Gut 62: 774-786.
71. Badylak, S.F., T. Hoppo, A. Nieponice, et al. 2011. Esophageal preservation in five male patients after endoscopic inner-layer circumferential resection in the setting of superficial cancer: a regenerative medicine approach with a biologic scaffold. Tissue Eng. Part A. 17: 1643-1650.