INHBA overexpression promotes cell proliferation and may be epigenetically regulated in esophageal adenocarcinoma

Journal of Thoracic Oncology

Volumn 4, Issue 4, 2009, Pages 455-462

  Seder, Christopher W ^a   Hartojo, Wibisono ^a   Lin, Lin ^a   Silvers, Amy L ^a   Wang, Zhuwen ^a   Thomas, Dafydd G ^a   Giordano, Thomas J ^a   Chen, Guoan ^a   Chang, Andrew C ^a   Orringer, Mark B ^a   Beer, David G ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Activin; Epigenetic regulation; Esophageal adenocarcinoma; INHBA

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ACTIVIN; FOLLISTATIN; HISTONE ACETYLTRANSFERASE; INHIBIN A; MESSENGER RNA; SMALL INTERFERING RNA; TRICHOSTATIN A; HISTONE ACETYLTRANSFERASE TYPE B COMPLEX; INHIBIN; INHIBIN BETA A SUBUNIT;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; ESOPHAGEAL ADENOCARCINOMA; GENE OVEREXPRESSION; GENE TARGETING; GENETIC REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN INDUCTION; UPREGULATION; ADENOCARCINOMA; ANIMAL; CATTLE; DRUG ANTAGONISM; DRUG EFFECT; ESOPHAGUS TUMOR; GENETIC EPIGENESIS; GENETICS; IMMUNOHISTOCHEMISTRY; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ACTIVINS; ADENOCARCINOMA; ANIMALS; CATTLE; CELL LINE, TUMOR; CELL PROLIFERATION; EPIGENESIS, GENETIC; ESOPHAGEAL NEOPLASMS; FOLLISTATIN; HISTONE ACETYLTRANSFERASES; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBIN-BETA SUBUNITS; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 67649391498     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e31819c791a     Document Type: Article

References (47)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43-66. (Pubitemid 46148091)
2. Beer DG, Kardia SL, Huang CC, et al. Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med 2002;8:816-824.
3. Garber ME, Troyanskaya OG, Schluens K, et al. Diversity of gene expression in adenocarcinoma of the lung. Proc Nat Acad Sci USA 2001;98:13784-13789. (Pubitemid 33115976)
4. Bhattacharjee A, Richards WG, Staunton J, et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci USA 2001;98:13790-13795. (Pubitemid 33115977)
5. Gaddy-Kurten D, Tsuchida K, Vale W, et al. Activins and the receptor serine kinase superfamily. Recent Prog Horm Res 1995;50:109-129.
6. Vale W, Rivier C, Hsueh A, et al. Chemical and biological characterization of the inhibin family of protein hormones. Recent Prog Horm Res 1988;44:1-34.
7. Lorenzen JR, Channing CP, Schwartz NB. Partial characterization of FSH suppressing activity (follicostatin) in porcine follicular fluid using the metestrous rat as an in vivo bioassay model. Biol Reprod 1978;19: 635-640.
8. Boitani C, Stefanini M, Fragale A, Morena AR. Activin stimulates Seroli cell proliferation in a defined period of rat testis development. Endocrinology 1995;136:5438-5444.
9. Green JB, New HV, Smith JC. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 1992;71:731-739.
10. Smith JC, Price JMB, van Nimmen K, Huylebroeck D. Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A. Nature 1990;345:729-731. (Pubitemid 20186552)
11. Yoshinaga K, Yamashita K, Mimori K, Tanaka F, Inoue H, Mori M. Activin A causes cancer cell aggressiveness in esophageal squamous cell carcinoma cells. Ann Surg Onc 2008;15:96-103.
12. Yoshinaga K, Mimori K, Yamashita K, Utsunomiya T, Inoue H, Mori M. Clinical significance of the expression of activin A in esophageal carcinoma. Int J Oncol 2003;22:75-80.
13. Matzuk MM, Finegold MJ, Jyan-Gwo JS, et al. Alpha-inhibin is a tumor suppressor gene with gonadal specificity in mice. Nature 1992;360:313-319.
14. Thomas TZ, Wang H, Niclasen P, et al. Expression and localization of activin subunits and follistatins in tissues from men with high grade prostate cancer. J Clin Endocrinol Metab 1997;82:3851-3858. (Pubitemid 27509382)
15. Kleeff J, Ishiwata T, Friess H, et al. Concomitant over-expression of activin/inhibin beta subunits and their receptors in human pancreatic cancer. Int J Cancer 1998;77:860-868. (Pubitemid 28378134)
16. Zheng W, Luo MP, Welt C, et al. Imbalanced expression of inhibin and activin subunits in primary epithelial ovarian cancer. Gynecol Oncol 1998;69:23-31. (Pubitemid 28201667)
17. Wildi S, Kleeff J, Maruyama H, Maurer CA, Buchler MW, Korc M. Overexpression of activin A in stage IV colorectal cancer. Gut 2001;49: 409-417. (Pubitemid 32802577)
18. Petraglia F, Florio P, Luisi S, et al. Expression and secretion of inhibin and activin in normal and neoplastic uterine tissues. High levels of serum activin A in women with endometrial and cervical carcinoma. J Clin Endocrinol Metab 1998;33:1194-1200. (Pubitemid 28496392)
19. Zhang Z, Zhao Y, Batres Y, Lin MF, Ying SY. Regulation of growth and prostatic marker expression by activin A in a androgen sensitive prostate cancer cell line LNCAP. Biochem Biophys Res Comm 1997;234:362-365. (Pubitemid 27243908)
20. Dalkin AC, Gilrain JT, Bradshaw D, et al. Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells. Endocrinology 1996;137:5230-5235. (Pubitemid 26423078)
21. McCarthy SA, Bicknell R. Inhibition of vascular endothelial cell growth by activin A. J Biol Chem 1993;268:23066-23071. (Pubitemid 23328013)
22. Liu QY, Niranjan B, Gomes P, et al. Inhibitory effects of activin on the growth and morphogenesis of primary transformed mammary epithelial cells. Cancer Res 1996;56:1155-1163. (Pubitemid 26065416)
23. Sternberg D, Honigwachs-Sha'anani J, Brosh N, Malik Z, Burstein Y, Zipori D. Restrictin-P/stromal activin A, kills its target cells via an apoptotic mechanism. Growth Factors 1995;12:277-287. (Pubitemid 26046273)
24. Yasuda H, Mine T, Shibata H, et al. Activin-A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J Clin Invest 1993;92: 1491-1496. (Pubitemid 23273929)
25. D'Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, Baetge EE. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 2005;23:1534-1541. (Pubitemid 41752931)
26. Hughes SJ, Nambu Y, Soldes OS, et al. Fas/APO-1 (CD95) is not translocated to the cell membrane in esophageal adenocarcinoma. Cancer Res 1997;57:5571-5578. (Pubitemid 28006766)
27. Giordano TJ, Shedden KA, Schwartz DR, et al. Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles. Am J Pathol 2001;159:1231-1238.
28. Lin J, Raoof DA, Wang Z, et al. Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma. Neoplasia 2006;8:1062-1071. (Pubitemid 44936156)
29. de Caestecker MP, Piek E, Roberts AB. Role of transforming growth factor-beta signaling in cancer. J Natl Cancer Inst 2000;92:1388-1402. (Pubitemid 30696191)
30. Wakefield LM, Piek E, Bottinger EP. TGF-beta signaling in mammarygland development and tumorigenesis. J Mammary Gland Biol Neoplasia 2001;6:67-82.
31. Massagué J, Blain SW, Lo RS. TGF-beta signaling in growth control, cancer, and heritable disorders. Cell 2000;103:295-309.
32. Petraglia F, Garg S, Florio P, et al. Activin A and activin B measured in maternal serum, cord blood serum and amniotic fluid during human pregnancy. Endocr J 1993;1:323-327.
33. Riley SC, Balfour C, Wathen NC, et al. Follistatin and activin A in extra-embryonic coelomic and amniotic fluids and maternal serum in early pregnancy. Hum Reprod 1998;13:2624-2628. (Pubitemid 28451252)
34. Luisi S, Battaglia C, Florio P, et al. Activin A and inhibin B in extra-embryonic coelomic and amniotic fluids, and maternal serum in early pregnancy. Placenta 1998;19:435-438. (Pubitemid 28327704)
35. Fowler PA, Evans LW, Groome NP, et al. A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-C and follistatin during pregnancy. Hum Reprod 1998;13:3530-3536.
36. Wallace EM, D'Antona D, Shearing C, et al. Amniotic fluid levels of dimeric inhibins, pro-C inhibin, activin A and follistatin in Down's syndrome. Clin Endocrinol 1999;50:669-673. (Pubitemid 29236345)
37. Muttukrishna S, Chamberlain P, Evans LW, et al. Amniotic fluid concentrations of dimeric inhibins, activin A and follistatin in pregnancy. Eur J Endocrinol 1999;140:420-424. (Pubitemid 29254008)
38. Debieve F, Beerlandt S, Hubinont C, et al. Gonadotropins, prolactin, inhibin A, inhibin B, and activin A in human fetal serum from midpregnancy and term pregnancy. J Clin Endocrinol Metab 2000; 85:270-274. (Pubitemid 32268825)
39. Matzuk MM, Kumar TR, Vassalli A, et al. Functional analysis of activins during mammalian development. Nature 1995;374:354-356.
40. Matzuk MM, Kumar TR, Bradley A. Different phenotypes for mice deficient in either activins or activin receptor type II. Nature 1995;374: 356-360.
41. Ueno N, Ling N, Ying SY, et al. Isolation and partial characterization of follistatin: A single-chain 35,000 monomeric protein that inhibits the release of follicle stimulating hormone. Proc Natl Acad Sci 1987;84: 8282-8286.
42. Robertson DM, Klein R, de Vos FL, et al. The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin. Biochem Biophys Res Commun 1987; 149:744-749. (Pubitemid 18023042)
43. Nakamura T, Takio K, Eto Y, et al. Activin binding protein from rat ovary is follistatin. Science 1990;247:836-838. (Pubitemid 20078560)
44. Hemmati-Brivanlou A, Kelly OG, Melton DA. Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell 1994;77:283-295. (Pubitemid 124000755)
45. Klose RJ, Bird AP. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 2006;31:89-97.
46. Fuks F. DNA methylation and histone modifications: teaming up to silence genes. Curr Opin Genet Dev 2005;15:490-495. (Pubitemid 41262404)
47. Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003; 33:245-254. (Pubitemid 36278835)