Protein ingestion increases myofibrillar protein synthesis after concurrent exercise

Medicine and Science in Sports and Exercise

Volumn 47, Issue 1, 2015, Pages 82-91

  Camera, Donny M ^a,b   West, Daniel W D ^c   Phillips, Stuart M ^c   Rerecich, Tracy ^c   Stellingwerff, Trent ^d,e   Hawley, John A ^a,f   Coffey, Vernon G ^b,g  

^a AUSTRALIAN CATHOLIC UNIVERSITY   (Australia)

^b RMIT UNIVERSITY   (Australia)

^c MCMASTER UNIVERSITY   (Canada)

^d NESTLÉ RESEARCH CENTER   (Switzerland)

^e CANADIAN SPORT INSTITUTE PACIFIC   (Canada)

^f LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^g QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Anabolic signaling; Atrogenes; Endurance exercise; Fractional synthetic rate; Resistance exercise

Indexed keywords

BMI1 PROTEIN; FBXO32 PROTEIN, HUMAN; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MTOR PROTEIN, HUMAN; MUSCLE PROTEIN; PPARGC1A PROTEIN, HUMAN; PROTEIN KINASE B; RING1 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE; WHEY PROTEIN;

ADOLESCENT; BIOSYNTHESIS; CROSSOVER PROCEDURE; DIETARY SUPPLEMENT; DOUBLE BLIND PROCEDURE; EXERCISE; GENETICS; HUMAN; MALE; METABOLISM; MUSCLE FIBRIL; PHOSPHORYLATION; PHYSIOLOGY; RANDOMIZATION; RESISTANCE TRAINING; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; YOUNG ADULT;

ADOLESCENT; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; EXERCISE; HUMANS; MALE; MITOCHONDRIAL PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOFIBRILS; PHOSPHORYLATION; POLYCOMB REPRESSIVE COMPLEX 1; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; RESISTANCE TRAINING; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; WHEY PROTEINS; YOUNG ADULT;

EID: 84926109527     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000000390     Document Type: Article

References (40)

1. Apró W, Wang L, Pontén M, Blomstrand E, Sahlin K. Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle. Am J Physiol Endocrinol Metab. 2013;305(1):E22-32.
2. Batterham A, Hopkins W. Making meaningful inferences about magnitudes. Int J Sports Physiol Perform. 2006;1(1):50-7.
3. Benziane B, Burton TJ, Scanlan B, et al. Divergent cell signaling after short-term intensified endurance training in human skeletal muscle. Am J Physiol Endocrinol Metab. 2008;295(6): E1427-38.
4. Borgenvik M, Apró W, Blomstrand E. Intake of branched-chain amino acids influences the levels of MAFbx mRNA and MuRF-1 total protein in resting and exercising human muscle. Am J Physiol Endocrinol Metab. 2012;302(5):E510-21.
5. Breen L, Philp A, Witard OC, et al. The influence of carbohydrate-protein co-ingestion following endurance exercise on myofibrillar and mitochondrial protein synthesis. J Physiol. 2011;589(16): 4011-25.
6. Camera DM, Edge J, Short MJ, Hawley JA, Coffey VG. Early time course of Akt phosphorylation after endurance and resistance exercise. Med Sci Sports Exerc. 2010;42(10):1843-52.
7. Camera DM, West DW, Burd NA, et al. Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise. J Appl Physiol. 2012;113(2):206-14.
8. Cermak NM, Res PT, de Groot LC, Saris WH, van Loon LJ. Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Am J Clin Nutr. 2012;96(6):1454-64.
9. Coffey VG, Moore DR, Burd NA, et al. Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints. Eur J Appl Physiol. 2011;111(7):1473-83.
10. Coffey VG, Hawley JA. The molecular bases of training adaptation. Sports Med. 2007;37(9):737-63.
11. Coffey VG, Jemiolo B, Edge J, Garnham AP, Trappe SW, Hawley JA. Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2009;297(5):R1441-51.
12. Coffey VG, Pilegaard H, Garnham AP, O'Brien BJ, Hawley JA. Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle. J Appl Physiol (1985). 2009; 106(4):1187-97.
13. D'Antona G, Lanfranconi F, Pellegrino MA, et al. Skeletal muscle hypertrophy and structure and function of skeletal muscle fibres in male body builders. J Physiol. 2006;570(3):611-27.
14. Di Donato DM, West DW, Churchward-Venne TA, Breen L, Baker SK, Phillips SM. Influence of aerobic exercise intensity on myofibrillar and mitochondrial protein synthesis in young men during early and late postexercise recovery. Am J Physiol Endocrinol Metab. 2014;306(9):E1025-32.
15. Donges CE, Burd NA, Duffield R, et al. Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men. J Appl Physiol (1985). 2012;112(12):1992-2001.
16. Dreyer HC, Fujita S, Cadenas JG, Chinkes DL, Volpi E, Rasmussen BB. Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol. 2006;576(2):613-24.
17. Dudley GA, Djamil R. Incompatibility of endurance- and strength-training modes of exercise. J Appl Physiol (1985). 1985;59(5): 1446-51.
18. Harber MP, Konopka AR, Jemiolo B, Trappe SW, Trappe TA, Reidy PT. Muscle protein synthesis and gene expression during recovery from aerobic exercise in the fasted and fed states. Am J Physiol Regul Integr Comp Physiol. 2010;299(5):R1254-62.
19. Hawley JA, Burke LM, Phillips SM, Spriet LL. Nutritional modulation of training-induced skeletal muscle adaptations. J Appl Physiol (1985). 2011;110(3):834-45.
20. Hickson RC. Interference of strength development by simultaneously training for strength and endurance. Eur J Appl Physiol Occup Physiol. 1980;45(2-3):255-63.
21. Holloszy JO, Booth FW. Biochemical adaptations to endurance exercise in muscle. Annu Rev Physiol. 1976;38(1):273-91.
22. Hopkins W, Marshall S, Batterham A, Hanin J. Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc. 2009;41(1):3-13.
23. Karavirta L, Häkkinen K, Kauhanen A, et al. Individual responses to combined endurance and strength training in older adults. Med Sci Sports Exerc. 2011;43(3):484-90.
24. Konopka AR, Harber MP. Skeletal muscle hypertrophy after aerobic exercise training. Exerc Sport Sci Rev. 2014;42(2):53-61.
25. Koopman R, Pennings B, Zorenc AH, van Loon LJ. Protein ingestion further augments S6K1 phosphorylation in skeletal muscle following resistance type exercise in males. J Nutr. 2007;137(8): 1880-6.
26. Leveritt M, Abernethy PJ, Barry BK, Logan PA. Concurrent strength and endurance training. A review. Sports Med. 1999; 28(6):413-27.
27. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2jΔΔCT method. Methods. 2001;25(4):402-8.
28. Louis E, Raue U, Yang Y, Jemiolo B, Trappe S. Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle. J Appl Physiol (1985). 2007; 103(5):1744-51.
29. Lundberg T, Fernandez-Gonzalo R, Gustafsson T, Tesch P. Aerobic exercise alters skeletal muscle molecular responses to resistance exercise. Med Sci Sports Exerc. 2012;44(9):1680-8.
30. Lundberg TR, Fernandez-Gonzalo R, Gustafsson T, Tesch PA. Aerobic exercise does not compromise muscle hypertrophy response to short-term resistance training. J Appl Physiol (1985). 2013;114(1):81-9.
31. Moore DR, Tang JE, Burd NA, Rerecich T, Tarnopolsky MA, Phillips SM. Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise. J Physiol. 2009;587:897-904.
32. Phillips BE, Williams JP, Gustafsson T, et al. Molecular networks of human muscle adaptation to exercise and age. PLoS Genet. 2013;9(3):e1003389.
33. Phillips SM, Tipton KD, Ferrando AA, Wolfe RR. Resistance training reduces the acute exercise-induced increase in muscle protein turnover. Am J Physiol Endocrinol Metab. 1999;276(1):E118-24.
34. Rowlands DS, Thomson JS, Timmons BW, et al. Transcriptome and translational signaling following endurance exercise in trained skeletal muscle: impact of dietary protein. Physiol Genomics. 2011;43(17):1004-20.
35. Scalzo RL, Peltonen GL, Binns SE, et al. Greater muscle protein synthesis and mitochondrial biogenesis in males compared with females during sprint interval training. FASEB J. 2014;28(6): 2705-14.
36. Timmons JA, Jansson E, Fischer H, et al. Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans. BMC Biol. 2005;3:19.
37. van Wijck K, Pennings B, van Bijnen AA, et al. Dietary protein digestion and absorption are impaired during acute postexercise recovery in young men. Am J Physiol Regul Integr Comp Physiol. 2013;304(5):R356-61.
38. Wang L, Mascher H, Psilander N, Blomstrand E, Sahlin K. Resistance exercise enhances the molecular signaling of mitochondrial biogenesis induced by endurance exercise in human skeletal muscle. J Appl Physiol (1985). 2011;111(5):1335-44.
39. Wilkinson SB, Phillips SM, Atherton PJ, et al. Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle. J Physiol. 2008;586(15):3701-17.
40. Wilson JM, Marin PJ, Rhea MR, Wilson SM, Loenneke JP, Anderson JC. Concurrent training: a meta-analysis examining interference of aerobic and resistance exercises. J Strength Cond Res. 2012;26(8):2293-307.