Dietary protein digestion and absorption are impaired during acute postexercise recovery in young men

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 304, Issue 5, 2013, Pages

  van Wijck, Kim ^a,b   Pennings, Bart ^a,b   van Bijnen, Annemarie A ^b   Senden, Joan M G ^b   Buurman, Wim A ^a,b   Dejong, Cornelis H C ^a,b   van Loon, Luc J C ^a,b   Lenaerts, Kaatje ^a,b  

^a TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Exercise; Hypoperfusion; Intestine; Nutrition; Postprandial

Indexed keywords

FATTY ACID BINDING PROTEIN; PHENYLALANINE; PROTEIN;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORRELATION ANALYSIS; DIGESTION; EXERCISE RECOVERY; GASTROINTESTINAL ABSORPTION; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; INTESTINE INJURY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN INTAKE; RESISTANCE TRAINING; SMALL INTESTINE DISEASE;

ACUTE DISEASE; AMINO ACIDS; DIETARY PROTEINS; DIGESTION; EXERCISE; HUMANS; INTESTINAL ABSORPTION; INTESTINAL DISEASES; INTESTINE, SMALL; MALE; MODELS, BIOLOGICAL; POSTPRANDIAL PERIOD; RESISTANCE TRAINING; YOUNG ADULT;

EID: 84874594128     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00294.2012     Document Type: Article

References (32)

1. Beelen M, Burke LM, Gibala MJ, van Loon LJ. Nutritional strategies to promote postexercise recovery. Int J Sport Nutr Exerc Metab 20: 515-532, 2010.
2. Biolo G, Tessari P, Inchiostro S, Bruttomesso D, Fongher C, Sabadin L, Fratton MG, Valerio A, Tiengo A. Leucine and phenylalanine kinetics during mixed meal ingestion: a multiple tracer approach. Am J Physiol Endocrinol Metab 262: E455-E463, 1992.
3. Blikslager AT. Life in the gut without oxygen: adaptive mechanisms and inflammatory bowel disease. Gastroenterology 134: 346-348, 2008.
4. Blikslager AT, Moeser AJ, Gookin JL, Jones SL, Odle J. Restoration of barrier function in injured intestinal mucosa. Physiol Rev 87: 545-564, 2007.
5. Boirie Y, Gachon P, Corny S, Fauquant J, Maubois JL, Beaufrere B. Acute postprandial changes in leucine metabolism as assessed with an intrinsically labeled milk protein. Am J Physiol Endocrinol Metab 271: E1083-E1091, 1996.
6. Bosenberg AT, Brock-Utne JG, Gaffin SL, Wells MT, Blake GT. Strenuous exercise causes systemic endotoxemia. J Appl Physiol 65: 106-108, 1988.
7. Bradley SE, Childs AW, Combes B, Cournand A, Wade OL, Wheeler HO. The effect of exercise on the splanchnic blood flow and splanchnic blood volume in normal man. Clin Sci (Lond) 15: 457-463, 1956.
8. Dangin M, Guillet C, Garcia-Rodenas C, Gachon P, Bouteloup-Demange C, Reiffers-Magnani K, Fauquant J, Ballevre O, Beaufrere B. The rate of protein digestion affects protein gain differently during aging in humans. J Physiol 549: 635-644, 2003.
9. de Haan JJ, Lubbers T, Derikx JP, Relja B, Henrich D, Greve JW, Marzi I, Buurman WA. Rapid development of intestinal cell damage following severe trauma: a prospective observational cohort study. Crit Care 13: R86, 2009.
10. Derikx JP, Matthijsen RA, de Bruine AP, van Bijnen AA, Heineman E, van Dam RM, Dejong CH, Buurman WA. Rapid reversal of human intestinal ischemia-reperfusion induced damage by shedding of injured enterocytes and reepithelialisation. PLos One 3: e3428, 2008.
11. Derikx JP, van Waardenburg DA, Thuijls G, Willigers HM, Koenraads M, van Bijnen AA, Heineman E, Poeze M, Ambergen T, van Ooij A, van Rhijn LW, Buurman WA. New insight in loss of gut barrier during major non-abdominal surgery. PLos One 3: e3954, 2008.
12. Freeman HJ, Kim YS, Sleisenger MH. Protein digestion and absorption in man. Normal mechanisms and protein-energy malnutrition. Am J Med 67: 1030-1036, 1979.
13. Grootjans J, Lenaerts K, Derikx JP, Matthijsen RA, de Bruine AP, van Bijnen AA, van Dam RM, Dejong CH, Buurman WA. Human intestinal ischemia-reperfusion-induced inflammation characterized: experiences from a new translational model. Am J Pathol 176: 2283-2291, 2010.
14. Hawley JA, Tipton KD, Millard-Stafford ML. Promoting training adaptations through nutritional interventions. J Sports Sci 24: 709-721, 2006.
15. Jeukendrup AE, Vet-Joop K, Sturk A, Stegen JH, Senden J, Saris WH, Wagenmakers AJ. Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clin Sci (Lond) 98: 47-55, 2000.
16. Koopman R, Saris WH, Wagenmakers AJ, van Loon LJ. Nutritional interventions to promote post-exercise muscle protein synthesis. Sports Med 37: 895-906, 2007.
17. Koopman R, Walrand S, Beelen M, Gijsen AP, Kies AK, Boirie Y, Saris WH, van Loon LJ. Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men. J Nutr 139: 1707-1713, 2009.
18. Levenhagen DK, Carr C, Carlson MG, Maron DJ, Borel MJ, Flakoll PJ. Postexercise protein intake enhances whole-body and leg protein accretion in humans. Med Sci Sports Ex 34: 828-837, 2002.
19. Levenhagen DK, Gresham JD, Carlson MG, Maron DJ, Borel MJ, Flakoll PJ. Postexercise nutrient intake timing in humans is critical to recovery of leg glucose and protein homeostasis. Am J Physiol Endocrinol Metab 280: E982-E993, 2001.
20. Marchbank T, Davison G, Oakes JR, Ghatei MA, Patterson M, Moyer MP, Playford RJ. The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. Am J Physiol Gastrointest Liver Physiol 300: G477-G484, 2011.
21. Mayhew JL, Prinster JL, Ware JS, Zimmer DL, Arabas JR, Bemben MG. Muscular endurance repetitions to predict bench press strength in men of different training levels. J Sports Med Phys Fitness 35: 108-113, 1995.
22. Nixon SE, Mawer GE. The digestion and absorption of protein in man. 1. The site of absorption. Br J Nutr 24: 227-240, 1970.
23. Oktedalen O, Lunde OC, Opstad PK, Aabakken L, Kvernebo K. Changes in the gastrointestinal mucosa after long-distance running. Scand J Gastroenterol 27: 270-274, 1992.
24. Pals KL, Chang RT, Ryan AJ, Gisolfi CV. Effect of running intensity on intestinal permeability. J Appl Physiol 82: 571-576, 1997.
25. Pennings B, Koopman R, Beelen M, Senden JM, Saris WH, van Loon LJ. Exercising before protein intake allows for greater use of dietary protein-derived amino acids for de novo muscle protein synthesis in both young and elderly men. Am J Clin Nutr 93: 322-331, 2011.
26. Pennings B, Pellikaan WF, Senden JM, van Vuuren AM, Sikkema J, van Loon LJ. The production of intrinsically labeled milk and meat protein is feasible and provides functional tools for human nutrition research. J Dairy Sci 94: 4366-4373, 2011.
27. Sieber C, Beglinger C, Jager K, Stalder GA. Intestinal phase of superior mesenteric artery blood flow in man. Gut 33: 497-501, 1992.
28. van Eijk HM, Rooyakkers DR, Deutz NE. Rapid routine determination of amino acids in plasma by high-performance liquid chromatography with a 2-3 microns Spherisorb ODS II column. J Chromatogr 620: 143-148, 1993.
29. van Loon LJ, Boirie Y, Gijsen AP, Fauquant J, de Roos AL, Kies AK, Lemosquet S, Saris WH, Koopman R. The production of intrinsically labeled milk protein provides a functional tool for human nutrition research. J Dairy Sci 92: 4812-4822, 2009.
30. van Wijck K, Lenaerts K, van Loon LJ, Peters WH, Buurman WA, Dejong CH. Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men. PLos One 6: e22366, 2011.
31. Verdijk LB, Jonkers RA, Gleeson BG, Beelen M, Meijer K, Savelberg HH, Wodzig WK, Dendale P, van Loon LJ. Protein supplementation before and after exercise does not further augment skeletal muscle hypertrophy after resistance training in elderly men. Am J Clin Nutr 89: 608-616, 2009.
32. Wolfe RR. Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. New York, NY: Wiley-Liss, 1992.