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Volumn 36, Issue 1-2, 2014, Pages 33-38

A review of the preclinical development of dexrazoxane

Author keywords

Cardioprotection; Dexrazoxane; Doxorubicin; Experimental models; Extravasation; Mechanism

Indexed keywords

ALLOXAN; BLEOMYCIN; DAUNORUBICIN; DOXORUBICIN; OXYGEN; PARACETAMOL; RAZOXANE;

EID: 84926101316     PISSN: 10589813     EISSN: 15581519     Source Type: Journal    
DOI: 10.1016/j.ppedcard.2014.09.006     Document Type: Review
Times cited : (13)

References (68)
  • 1
    • 0015990773 scopus 로고
    • Adriamycin: a new anticancer drug with significant clinical activity
    • Blum R.H., Carter S.K. Adriamycin: a new anticancer drug with significant clinical activity. Ann Intern Med 1974, 80:244-259.
    • (1974) Ann Intern Med , vol.80 , pp. 244-259
    • Blum, R.H.1    Carter, S.K.2
  • 3
    • 0031658201 scopus 로고    scopus 로고
    • Preclinical animal models of cardiac protection from anthracycline-induced cardiotoxicity
    • Herman E.H., Ferrans V.J. Preclinical animal models of cardiac protection from anthracycline-induced cardiotoxicity. Semin Oncol 1998, (Suppl. 10):15-21.
    • (1998) Semin Oncol , pp. 15-21
    • Herman, E.H.1    Ferrans, V.J.2
  • 4
    • 0031420364 scopus 로고    scopus 로고
    • Animal models of anthracycline cardiotoxicity: basic mechanisms and cardioprotective activity
    • Herman E.H., Ferrans V.J. Animal models of anthracycline cardiotoxicity: basic mechanisms and cardioprotective activity. Prog Pediatr Cardiol 1998, 8:49-58.
    • (1998) Prog Pediatr Cardiol , vol.8 , pp. 49-58
    • Herman, E.H.1    Ferrans, V.J.2
  • 5
    • 0000137504 scopus 로고
    • Methods of reducing anthracycline cardiotoxicity
    • Johns Hopkins Press, Baltimore, F. Muggia, M.D. Green, J. Speyer (Eds.)
    • Herman E.H., Ferrans V.J., Sanchez J. Methods of reducing anthracycline cardiotoxicity. Cancer Treatment and the Heart 1992, 114-169. Johns Hopkins Press, Baltimore. F. Muggia, M.D. Green, J. Speyer (Eds.).
    • (1992) Cancer Treatment and the Heart , pp. 114-169
    • Herman, E.H.1    Ferrans, V.J.2    Sanchez, J.3
  • 6
    • 84873836880 scopus 로고    scopus 로고
    • Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection
    • Sterba M., Popelova O., Vavrova A., et al. Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection. Antioxid Redox Signal 2013, 18:899-929.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 899-929
    • Sterba, M.1    Popelova, O.2    Vavrova, A.3
  • 7
    • 0015849162 scopus 로고
    • A clinicopathologic analysis of adriamycin cardiotoxicity
    • Lefrak E.A., Pitha J., Rosenheim S., Gottlieb J.A. A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 1973, 32:302-314.
    • (1973) Cancer , vol.32 , pp. 302-314
    • Lefrak, E.A.1    Pitha, J.2    Rosenheim, S.3    Gottlieb, J.A.4
  • 8
    • 0014493234 scopus 로고
    • Comparative cardiac toxicity of daunomycin in three rodent species
    • Herman E.H., Schein P., Farmer R.M. Comparative cardiac toxicity of daunomycin in three rodent species. Proc Soc Exp Biol Med 1970, 130:1098-1102.
    • (1970) Proc Soc Exp Biol Med , vol.130 , pp. 1098-1102
    • Herman, E.H.1    Schein, P.2    Farmer, R.M.3
  • 9
    • 0014730044 scopus 로고
    • The acute pharmacological actions of daunomycin in the dog and monkey
    • Herman E.H., Vick J.A. The acute pharmacological actions of daunomycin in the dog and monkey. Pharmacology 1970, 3:291-304.
    • (1970) Pharmacology , vol.3 , pp. 291-304
    • Herman, E.H.1    Vick, J.A.2
  • 10
    • 0014818155 scopus 로고
    • Role of the sympathetic nervous system in daunomycin-induced arrhythmia in the monkey
    • Burka B., Herman E., Vick J. Role of the sympathetic nervous system in daunomycin-induced arrhythmia in the monkey. Br J Pharmacol 1970, 39:501-510.
    • (1970) Br J Pharmacol , vol.39 , pp. 501-510
    • Burka, B.1    Herman, E.2    Vick, J.3
  • 11
    • 0015185424 scopus 로고
    • An isolated dog or monkey heart preparation for studying cardioactive compounds
    • Vick J.A., Herman E.H. An isolated dog or monkey heart preparation for studying cardioactive compounds. Pharmacology 1971, 6:290-299.
    • (1971) Pharmacology , vol.6 , pp. 290-299
    • Vick, J.A.1    Herman, E.H.2
  • 12
    • 0015337898 scopus 로고
    • Prevention of the cardiotoxic effects of adriamycin and daunomycin in the isolated dog heart
    • Herman E.H., Mhatre R.M., Lee I.P., Waravdekar V.S. Prevention of the cardiotoxic effects of adriamycin and daunomycin in the isolated dog heart. Proc Soc Exp Biol Med 1972, 140:234-239.
    • (1972) Proc Soc Exp Biol Med , vol.140 , pp. 234-239
    • Herman, E.H.1    Mhatre, R.M.2    Lee, I.P.3    Waravdekar, V.S.4
  • 15
    • 0022620588 scopus 로고
    • Pretreatment with ICRF-187 provides long lasting protection against chronic daunorubicin cardiotoxicity in rabbits
    • Herman E.H., Ferrans V.J. Pretreatment with ICRF-187 provides long lasting protection against chronic daunorubicin cardiotoxicity in rabbits. Cancer Chemother Pharmacol 1986, 16:102-106.
    • (1986) Cancer Chemother Pharmacol , vol.16 , pp. 102-106
    • Herman, E.H.1    Ferrans, V.J.2
  • 16
    • 0019518585 scopus 로고
    • Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (+/-)-1,2-bis(3,5-dioxopiperazynl-1-propane (ICRF-187)
    • Herman E.H., Ferrans V.J. Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (+/-)-1,2-bis(3,5-dioxopiperazynl-1-propane (ICRF-187). Cancer Res 1981, 41:3436-3440.
    • (1981) Cancer Res , vol.41 , pp. 3436-3440
    • Herman, E.H.1    Ferrans, V.J.2
  • 17
    • 0021814289 scopus 로고
    • Comparison of the severity of the chronic cardiac cardiotoxicity produced by doxorubicin in normotensive and hypertensive rats
    • Herman E.H., El-Hage A.N., Ferrans V.J., Ardalan B. Comparison of the severity of the chronic cardiac cardiotoxicity produced by doxorubicin in normotensive and hypertensive rats. Toxicol Appl Parmacol 1983, 78:202-214.
    • (1983) Toxicol Appl Parmacol , vol.78 , pp. 202-214
    • Herman, E.H.1    El-Hage, A.N.2    Ferrans, V.J.3    Ardalan, B.4
  • 18
    • 0023873326 scopus 로고
    • Protective effect of ICRF-187 on doxorubicin-induced cardiac and renal toxicity in spontaneously hypertensive (SHR) and normotensive (WKY) rats
    • Herman E.H., El-Hage A.N., Ferrans V.J. Protective effect of ICRF-187 on doxorubicin-induced cardiac and renal toxicity in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Toxicol Appl Pharmacol 1988, 92:42-53.
    • (1988) Toxicol Appl Pharmacol , vol.92 , pp. 42-53
    • Herman, E.H.1    El-Hage, A.N.2    Ferrans, V.J.3
  • 19
    • 0027181374 scopus 로고
    • Timing of treatment with ICRF-187 and its effect on chronic doxorubicin cardiotoxicity
    • Herman E.H., Ferrans V.J. Timing of treatment with ICRF-187 and its effect on chronic doxorubicin cardiotoxicity. Cancer Chemother Pharmacol 1993, 32:445-449.
    • (1993) Cancer Chemother Pharmacol , vol.32 , pp. 445-449
    • Herman, E.H.1    Ferrans, V.J.2
  • 20
    • 0024217559 scopus 로고
    • Effect of pretreatment with ICRF-187 on the total cumulative dose of doxorubicin tolerated by beagle dogs
    • Herman E.H., Ferrans V.J., Young R.S., Hamlin R.L. Effect of pretreatment with ICRF-187 on the total cumulative dose of doxorubicin tolerated by beagle dogs. Cancer Res 1988, 48:6918-6925.
    • (1988) Cancer Res , vol.48 , pp. 6918-6925
    • Herman, E.H.1    Ferrans, V.J.2    Young, R.S.3    Hamlin, R.L.4
  • 21
    • 0023693833 scopus 로고
    • Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiotoxicity in women with advanced breast cancer
    • Speyer J.L., Green M.D., Kramer E., et al. Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiotoxicity in women with advanced breast cancer. New Engl J Med 1988, 319:745-752.
    • (1988) New Engl J Med , vol.319 , pp. 745-752
    • Speyer, J.L.1    Green, M.D.2    Kramer, E.3
  • 22
    • 77957355941 scopus 로고    scopus 로고
    • Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long term follow-up
    • Lipshultz S.E., Scully R.E., Lipsitz S.R., et al. Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long term follow-up. Lancet Oncol 2010, 11:950-961.
    • (2010) Lancet Oncol , vol.11 , pp. 950-961
    • Lipshultz, S.E.1    Scully, R.E.2    Lipsitz, S.R.3
  • 23
    • 84866688380 scopus 로고    scopus 로고
    • Dexrazoxane for the prevention of cardiac toxicity and treatment of extravasation injury from the anthracycline antibiotics
    • Doroshow J.H. Dexrazoxane for the prevention of cardiac toxicity and treatment of extravasation injury from the anthracycline antibiotics. Curr Pharm Biotechnol 2012, 13:1949-1956.
    • (2012) Curr Pharm Biotechnol , vol.13 , pp. 1949-1956
    • Doroshow, J.H.1
  • 24
    • 0031974196 scopus 로고    scopus 로고
    • Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity
    • Herman E.H., Lipshultz S.E., Rifai N., et al. Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity. Cancer Res 1998, 58:1995-1997.
    • (1998) Cancer Res , vol.58 , pp. 1995-1997
    • Herman, E.H.1    Lipshultz, S.E.2    Rifai, N.3
  • 25
    • 0032983504 scopus 로고    scopus 로고
    • Correlation between the serum levels of cardiac troponin T and the severity of the chronic cardiomyopathy induced by doxorubicin
    • Herman E.H., Zhang J., Lipshultz S.E., et al. Correlation between the serum levels of cardiac troponin T and the severity of the chronic cardiomyopathy induced by doxorubicin. J Clin Oncol 1999, 17:2237-2243.
    • (1999) J Clin Oncol , vol.17 , pp. 2237-2243
    • Herman, E.H.1    Zhang, J.2    Lipshultz, S.E.3
  • 26
    • 0033817796 scopus 로고    scopus 로고
    • Treatment of anthracycline extravasation with dexrazoxane
    • Langer S.W., Sehested M., Jensen P.B. Treatment of anthracycline extravasation with dexrazoxane. Clin Cancer Res 2000, 6:3680-3686.
    • (2000) Clin Cancer Res , vol.6 , pp. 3680-3686
    • Langer, S.W.1    Sehested, M.2    Jensen, P.B.3
  • 28
    • 33847662074 scopus 로고    scopus 로고
    • Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies
    • Mouridsen H.T., Langer S.W., Buter J., et al. Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies. Ann Oncol 2007, 18:546-550.
    • (2007) Ann Oncol , vol.18 , pp. 546-550
    • Mouridsen, H.T.1    Langer, S.W.2    Buter, J.3
  • 29
    • 39049089593 scopus 로고    scopus 로고
    • The use of dexrazoxane for the prevention of anthracycline extravasation injury
    • Hasinoff B.B. The use of dexrazoxane for the prevention of anthracycline extravasation injury. Expert Opin Investig Drugs 2008, 17:217-223.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 217-223
    • Hasinoff, B.B.1
  • 31
    • 0021084131 scopus 로고
    • Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters
    • El-Hage A.N., Herman E.H., Ferrans V.J. Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters. Toxicology 1983, 28:295-303.
    • (1983) Toxicology , vol.28 , pp. 295-303
    • El-Hage, A.N.1    Herman, E.H.2    Ferrans, V.J.3
  • 32
    • 0026701351 scopus 로고
    • Effect of ICRF-187 on the pulmonary damage induced by hypoxia in the rat
    • Fukuda Y., Herman E.H., Ferrans V.J. Effect of ICRF-187 on the pulmonary damage induced by hypoxia in the rat. Toxicology 1992, 74:186-202.
    • (1992) Toxicology , vol.74 , pp. 186-202
    • Fukuda, Y.1    Herman, E.H.2    Ferrans, V.J.3
  • 33
    • 0028915312 scopus 로고
    • Morphologic and morphometric evaluation of the effect of ICRF-187 on bleomycin-induced pulmonary toxicity
    • Herman E.H., Hasinoff B.B., Zhang J., et al. Morphologic and morphometric evaluation of the effect of ICRF-187 on bleomycin-induced pulmonary toxicity. Toxicology 1995, 98:163-175.
    • (1995) Toxicology , vol.98 , pp. 163-175
    • Herman, E.H.1    Hasinoff, B.B.2    Zhang, J.3
  • 34
    • 34548299563 scopus 로고    scopus 로고
    • Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?
    • Hasinoff B.B., Herman E.H. Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?. Cardiovasc Toxicol 2007, 7:140-144.
    • (2007) Cardiovasc Toxicol , vol.7 , pp. 140-144
    • Hasinoff, B.B.1    Herman, E.H.2
  • 35
    • 84926130100 scopus 로고    scopus 로고
    • The pharmacology of dexrazoxane: iron chelating prodrug and topoisomerase II inhibitor
    • Springer, Dordrecht, K. Hellmann, W. Rhomberg (Eds.)
    • Hasinoff B.B. The pharmacology of dexrazoxane: iron chelating prodrug and topoisomerase II inhibitor. Razoxane and Dexrazoxane-Two Multifunctional Agents 2010, 158-167. Springer, Dordrecht. K. Hellmann, W. Rhomberg (Eds.).
    • (2010) Razoxane and Dexrazoxane-Two Multifunctional Agents , pp. 158-167
    • Hasinoff, B.B.1
  • 36
    • 39049089593 scopus 로고    scopus 로고
    • The use of dexrazoxane for the prevention of anthracycline extravasation injury
    • Hasinoff B.B. The use of dexrazoxane for the prevention of anthracycline extravasation injury. Expert Opin Investig Drugs 2008, 17:217-223.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 217-223
    • Hasinoff, B.B.1
  • 37
    • 0028810791 scopus 로고
    • A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane)
    • Hasinoff B.B., Kuschak T.I., Yalowich J.C., Creighton A.M. A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane). Biochem Pharmacol 1995, 50:953-958.
    • (1995) Biochem Pharmacol , vol.50 , pp. 953-958
    • Hasinoff, B.B.1    Kuschak, T.I.2    Yalowich, J.C.3    Creighton, A.M.4
  • 38
    • 84891511978 scopus 로고    scopus 로고
    • A high-throughput fluorescence anisotropy-based assay for human topoisomerase II beta-catalyzed ATP-dependent supercoiled DNA relaxation
    • Shapiro A.B., Austin C.A. A high-throughput fluorescence anisotropy-based assay for human topoisomerase II beta-catalyzed ATP-dependent supercoiled DNA relaxation. Anal Biochem 2014, 448:23-29.
    • (2014) Anal Biochem , vol.448 , pp. 23-29
    • Shapiro, A.B.1    Austin, C.A.2
  • 39
    • 0031906718 scopus 로고    scopus 로고
    • Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines
    • Hasinoff B.B., Hellmann K., Herman E.H., Ferrans V.J. Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines. Curr Med Chem 1998, 5:1-28.
    • (1998) Curr Med Chem , vol.5 , pp. 1-28
    • Hasinoff, B.B.1    Hellmann, K.2    Herman, E.H.3    Ferrans, V.J.4
  • 40
    • 34548785032 scopus 로고    scopus 로고
    • Topoisomerase IIβ mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane
    • Lyu Y.L., Kerrigan J.E., Lin C.P., et al. Topoisomerase IIβ mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane. Cancer Res 2007, 67:8839-8846.
    • (2007) Cancer Res , vol.67 , pp. 8839-8846
    • Lyu, Y.L.1    Kerrigan, J.E.2    Lin, C.P.3
  • 41
    • 84891009434 scopus 로고    scopus 로고
    • Topoisomerase 2β: a promising molecular target for primary prevention of anthracycline-induced cardiotoxicity
    • Vejpongsa P., Yeh E.T. Topoisomerase 2β: a promising molecular target for primary prevention of anthracycline-induced cardiotoxicity. Clin Pharmacol Ther 2014, 95:45-52.
    • (2014) Clin Pharmacol Ther , vol.95 , pp. 45-52
    • Vejpongsa, P.1    Yeh, E.T.2
  • 42
    • 84869209094 scopus 로고    scopus 로고
    • Identification of the molecular basis of doxorubicin-induced cardiotoxicity
    • Zhang S., Liu X., Bawa-Khalfe T., et al. Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med 2012, 18:1639-1642.
    • (2012) Nat Med , vol.18 , pp. 1639-1642
    • Zhang, S.1    Liu, X.2    Bawa-Khalfe, T.3
  • 43
    • 0016775708 scopus 로고
    • Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells
    • Dawson K.M. Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells. Biochem Pharmacol 1975, 24:2249-2253.
    • (1975) Biochem Pharmacol , vol.24 , pp. 2249-2253
    • Dawson, K.M.1
  • 44
    • 0034136253 scopus 로고    scopus 로고
    • Iron complexes of the cardioprotective agent dexrazoxane (ICRF-187) and its desmethyl derivative, ICRF-154: solid state structure, solution thermodynamics, and DNA cleavage activity
    • Diop N.K., Vitellaro L.K., Arnold P., Shang M., Marusak R.A. Iron complexes of the cardioprotective agent dexrazoxane (ICRF-187) and its desmethyl derivative, ICRF-154: solid state structure, solution thermodynamics, and DNA cleavage activity. J Inorg Biochem 2000, 78:209-216.
    • (2000) J Inorg Biochem , vol.78 , pp. 209-216
    • Diop, N.K.1    Vitellaro, L.K.2    Arnold, P.3    Shang, M.4    Marusak, R.A.5
  • 45
    • 0041854306 scopus 로고    scopus 로고
    • The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity
    • Hasinoff B.B., Schroeder P.E., Patel D. The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity. Mol Pharmacol 2003, 64:670-678.
    • (2003) Mol Pharmacol , vol.64 , pp. 670-678
    • Hasinoff, B.B.1    Schroeder, P.E.2    Patel, D.3
  • 46
    • 0036363028 scopus 로고    scopus 로고
    • Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxia-reoxygenation damage
    • Hasinoff B.B. Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxia-reoxygenation damage. Cardiovasc Toxicol 2002, 2:111-118.
    • (2002) Cardiovasc Toxicol , vol.2 , pp. 111-118
    • Hasinoff, B.B.1
  • 47
    • 0027740137 scopus 로고
    • The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes
    • Buss J.L., Hasinoff B.B. The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes. Agents Actions 1993, 40:86-95.
    • (1993) Agents Actions , vol.40 , pp. 86-95
    • Buss, J.L.1    Hasinoff, B.B.2
  • 48
    • 0033628701 scopus 로고    scopus 로고
    • Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice
    • Fortune J.M., Osheroff N. Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Prog Nucleic Acid Res Mol Biol 2000, 64:221-253.
    • (2000) Prog Nucleic Acid Res Mol Biol , vol.64 , pp. 221-253
    • Fortune, J.M.1    Osheroff, N.2
  • 49
    • 0033006172 scopus 로고    scopus 로고
    • A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
    • Gewirtz D.A. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol 1999, 57:727-741.
    • (1999) Biochem Pharmacol , vol.57 , pp. 727-741
    • Gewirtz, D.A.1
  • 50
    • 77954187741 scopus 로고    scopus 로고
    • DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
    • Pommier Y., Leo E., Zhang H., Marchand C. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol 2010, 17:421-433.
    • (2010) Chem Biol , vol.17 , pp. 421-433
    • Pommier, Y.1    Leo, E.2    Zhang, H.3    Marchand, C.4
  • 51
    • 0034075866 scopus 로고    scopus 로고
    • Localization of dichlorofluorescein in cardiac myocytes: implications for assessment of oxidative stress
    • Swift L.M., Sarvazyan N. Localization of dichlorofluorescein in cardiac myocytes: implications for assessment of oxidative stress. Am J Physiol Heart Circ Physiol 2000, 278:H982-H990.
    • (2000) Am J Physiol Heart Circ Physiol , vol.278 , pp. H982-H990
    • Swift, L.M.1    Sarvazyan, N.2
  • 52
    • 0642280672 scopus 로고    scopus 로고
    • Dexrazoxane (ICRF-187) protects cardiac myocytes against doxorubicin by preventing damage to mitochondria
    • Hasinoff B.B., Schnabl K.L., Marusak R.A., Patel D., Huebner E. Dexrazoxane (ICRF-187) protects cardiac myocytes against doxorubicin by preventing damage to mitochondria. Cardiovasc Toxicol 2003, 3:89-99.
    • (2003) Cardiovasc Toxicol , vol.3 , pp. 89-99
    • Hasinoff, B.B.1    Schnabl, K.L.2    Marusak, R.A.3    Patel, D.4    Huebner, E.5
  • 53
    • 33750688601 scopus 로고    scopus 로고
    • Visualization of doxorubicin-induced oxidative stress in isolated cardiac myocytes
    • Sarvazyan N. Visualization of doxorubicin-induced oxidative stress in isolated cardiac myocytes. Am J Physiol 1996, 271:H2079-H2085.
    • (1996) Am J Physiol , vol.271 , pp. H2079-H2085
    • Sarvazyan, N.1
  • 54
    • 0038596403 scopus 로고    scopus 로고
    • Hydroxyl radical production by the iron complex of the hydrolysis product of the antioxidant cardioprotective agent ICRF-187 (dexrazoxane)
    • Malisza K.L., Hasinoff B.B. Hydroxyl radical production by the iron complex of the hydrolysis product of the antioxidant cardioprotective agent ICRF-187 (dexrazoxane). Redox Rep 1996, 2:69-73.
    • (1996) Redox Rep , vol.2 , pp. 69-73
    • Malisza, K.L.1    Hasinoff, B.B.2
  • 56
    • 1842866539 scopus 로고    scopus 로고
    • Dihydroorotase catalyzes the ring-opening of the hydrolysis intermediates of the cardioprotective drug dexrazoxane (ICRF-187)
    • Schroeder P.E., Davidson J.N., Hasinoff B.B. Dihydroorotase catalyzes the ring-opening of the hydrolysis intermediates of the cardioprotective drug dexrazoxane (ICRF-187). Drug Metab Dispos 2002, 30:1431-1435.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1431-1435
    • Schroeder, P.E.1    Davidson, J.N.2    Hasinoff, B.B.3
  • 57
    • 18844435708 scopus 로고    scopus 로고
    • Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes and by blood
    • Schroeder P.E., Wang G.Q., Burczynski F.J., Hasinoff B.B. Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes and by blood. Drug Metab Dispos 2005, 33:719-725.
    • (2005) Drug Metab Dispos , vol.33 , pp. 719-725
    • Schroeder, P.E.1    Wang, G.Q.2    Burczynski, F.J.3    Hasinoff, B.B.4
  • 58
    • 23944434434 scopus 로고    scopus 로고
    • Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal chelating form in the rat
    • Schroeder P.E., Hasinoff B.B. Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal chelating form in the rat. Drug Metab Dispos 2005, 33:1367-1372.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1367-1372
    • Schroeder, P.E.1    Hasinoff, B.B.2
  • 59
    • 50049129357 scopus 로고    scopus 로고
    • The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites
    • Schroeder P.E., Patel D., Hasinoff B.B. The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites. Drug Metab Dispos 2008, 36:1780-1785.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1780-1785
    • Schroeder, P.E.1    Patel, D.2    Hasinoff, B.B.3
  • 60
    • 63349086953 scopus 로고    scopus 로고
    • The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing
    • Deweese J.E., Osheroff N. The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res 2009, 37:738-748.
    • (2009) Nucleic Acids Res , vol.37 , pp. 738-748
    • Deweese, J.E.1    Osheroff, N.2
  • 61
    • 64649090292 scopus 로고    scopus 로고
    • Targeting DNA, topoisomerase II in cancer chemotherapy
    • Nitiss J.L. Targeting DNA, topoisomerase II in cancer chemotherapy. Nat Rev Cancer 2009, 9:338-350.
    • (2009) Nat Rev Cancer , vol.9 , pp. 338-350
    • Nitiss, J.L.1
  • 62
    • 0141591551 scopus 로고    scopus 로고
    • Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187
    • Classen S., Olland S., Berger J.M. Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A 2003, 100:14510.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14510
    • Classen, S.1    Olland, S.2    Berger, J.M.3
  • 63
    • 0141591551 scopus 로고    scopus 로고
    • Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187
    • Classen S., Olland S., Berger J.M. Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A 2003, 100:10629-10634.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10629-10634
    • Classen, S.1    Olland, S.2    Berger, J.M.3
  • 64
    • 84855347756 scopus 로고    scopus 로고
    • Interfacial inhibitors: targeting macromolecular complexes
    • Pommier Y., Marchand C. Interfacial inhibitors: targeting macromolecular complexes. Nat Rev Drug Discov 2012, 11:25-36.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 25-36
    • Pommier, Y.1    Marchand, C.2
  • 65
    • 84872547120 scopus 로고    scopus 로고
    • Drugging topoisomerases: lessons and challenges
    • Pommier Y. Drugging topoisomerases: lessons and challenges. ACS Chem Biol 2013, 8:82-95.
    • (2013) ACS Chem Biol , vol.8 , pp. 82-95
    • Pommier, Y.1
  • 66
    • 0742269397 scopus 로고    scopus 로고
    • The current and future role of dexrazoxane as a cardioprotectant in anthracycline treatment: expert panel review
    • Swain S.M., Vici P. The current and future role of dexrazoxane as a cardioprotectant in anthracycline treatment: expert panel review. J Cancer Res Clin Oncol 2004, 130:1-7.
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 1-7
    • Swain, S.M.1    Vici, P.2
  • 67
    • 57449120634 scopus 로고    scopus 로고
    • Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy
    • Martin E., Thougaard A.V., Grauslund M., et al. Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy. Toxicology 2009, 255:72-79.
    • (2009) Toxicology , vol.255 , pp. 72-79
    • Martin, E.1    Thougaard, A.V.2    Grauslund, M.3
  • 68
    • 0021812284 scopus 로고
    • Comparison of the protective effect of ICRF-187 and structurally related analogues against acute daunorubicin toxicity in Syrian golden hamsters
    • Herman E.H., El-Hage A.N., Creighton A.M., Witiak D.T., Ferrans V.J. Comparison of the protective effect of ICRF-187 and structurally related analogues against acute daunorubicin toxicity in Syrian golden hamsters. Res Commun Chem Pathol Pharmacol 1985, 48:39-55.
    • (1985) Res Commun Chem Pathol Pharmacol , vol.48 , pp. 39-55
    • Herman, E.H.1    El-Hage, A.N.2    Creighton, A.M.3    Witiak, D.T.4    Ferrans, V.J.5


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