-
1
-
-
0015990773
-
Adriamycin: a new anticancer drug with significant clinical activity
-
Blum R.H., Carter S.K. Adriamycin: a new anticancer drug with significant clinical activity. Ann Intern Med 1974, 80:244-259.
-
(1974)
Ann Intern Med
, vol.80
, pp. 244-259
-
-
Blum, R.H.1
Carter, S.K.2
-
2
-
-
0016708242
-
Adriamycin (NSC 123127) cardiotoxicity: a clinicopathologic correlation
-
Cortes E.P., Lutman G., Wanta J., Wallace J., Holland J. Adriamycin (NSC 123127) cardiotoxicity: a clinicopathologic correlation. Cancer Chemother Rep 1975, 6(part3):215-225.
-
(1975)
Cancer Chemother Rep
, vol.6
, pp. 215-225
-
-
Cortes, E.P.1
Lutman, G.2
Wanta, J.3
Wallace, J.4
Holland, J.5
-
3
-
-
0031658201
-
Preclinical animal models of cardiac protection from anthracycline-induced cardiotoxicity
-
Herman E.H., Ferrans V.J. Preclinical animal models of cardiac protection from anthracycline-induced cardiotoxicity. Semin Oncol 1998, (Suppl. 10):15-21.
-
(1998)
Semin Oncol
, pp. 15-21
-
-
Herman, E.H.1
Ferrans, V.J.2
-
4
-
-
0031420364
-
Animal models of anthracycline cardiotoxicity: basic mechanisms and cardioprotective activity
-
Herman E.H., Ferrans V.J. Animal models of anthracycline cardiotoxicity: basic mechanisms and cardioprotective activity. Prog Pediatr Cardiol 1998, 8:49-58.
-
(1998)
Prog Pediatr Cardiol
, vol.8
, pp. 49-58
-
-
Herman, E.H.1
Ferrans, V.J.2
-
5
-
-
0000137504
-
Methods of reducing anthracycline cardiotoxicity
-
Johns Hopkins Press, Baltimore, F. Muggia, M.D. Green, J. Speyer (Eds.)
-
Herman E.H., Ferrans V.J., Sanchez J. Methods of reducing anthracycline cardiotoxicity. Cancer Treatment and the Heart 1992, 114-169. Johns Hopkins Press, Baltimore. F. Muggia, M.D. Green, J. Speyer (Eds.).
-
(1992)
Cancer Treatment and the Heart
, pp. 114-169
-
-
Herman, E.H.1
Ferrans, V.J.2
Sanchez, J.3
-
6
-
-
84873836880
-
Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection
-
Sterba M., Popelova O., Vavrova A., et al. Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection. Antioxid Redox Signal 2013, 18:899-929.
-
(2013)
Antioxid Redox Signal
, vol.18
, pp. 899-929
-
-
Sterba, M.1
Popelova, O.2
Vavrova, A.3
-
7
-
-
0015849162
-
A clinicopathologic analysis of adriamycin cardiotoxicity
-
Lefrak E.A., Pitha J., Rosenheim S., Gottlieb J.A. A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 1973, 32:302-314.
-
(1973)
Cancer
, vol.32
, pp. 302-314
-
-
Lefrak, E.A.1
Pitha, J.2
Rosenheim, S.3
Gottlieb, J.A.4
-
8
-
-
0014493234
-
Comparative cardiac toxicity of daunomycin in three rodent species
-
Herman E.H., Schein P., Farmer R.M. Comparative cardiac toxicity of daunomycin in three rodent species. Proc Soc Exp Biol Med 1970, 130:1098-1102.
-
(1970)
Proc Soc Exp Biol Med
, vol.130
, pp. 1098-1102
-
-
Herman, E.H.1
Schein, P.2
Farmer, R.M.3
-
9
-
-
0014730044
-
The acute pharmacological actions of daunomycin in the dog and monkey
-
Herman E.H., Vick J.A. The acute pharmacological actions of daunomycin in the dog and monkey. Pharmacology 1970, 3:291-304.
-
(1970)
Pharmacology
, vol.3
, pp. 291-304
-
-
Herman, E.H.1
Vick, J.A.2
-
10
-
-
0014818155
-
Role of the sympathetic nervous system in daunomycin-induced arrhythmia in the monkey
-
Burka B., Herman E., Vick J. Role of the sympathetic nervous system in daunomycin-induced arrhythmia in the monkey. Br J Pharmacol 1970, 39:501-510.
-
(1970)
Br J Pharmacol
, vol.39
, pp. 501-510
-
-
Burka, B.1
Herman, E.2
Vick, J.3
-
11
-
-
0015185424
-
An isolated dog or monkey heart preparation for studying cardioactive compounds
-
Vick J.A., Herman E.H. An isolated dog or monkey heart preparation for studying cardioactive compounds. Pharmacology 1971, 6:290-299.
-
(1971)
Pharmacology
, vol.6
, pp. 290-299
-
-
Vick, J.A.1
Herman, E.H.2
-
12
-
-
0015337898
-
Prevention of the cardiotoxic effects of adriamycin and daunomycin in the isolated dog heart
-
Herman E.H., Mhatre R.M., Lee I.P., Waravdekar V.S. Prevention of the cardiotoxic effects of adriamycin and daunomycin in the isolated dog heart. Proc Soc Exp Biol Med 1972, 140:234-239.
-
(1972)
Proc Soc Exp Biol Med
, vol.140
, pp. 234-239
-
-
Herman, E.H.1
Mhatre, R.M.2
Lee, I.P.3
Waravdekar, V.S.4
-
13
-
-
0020615079
-
Reduction by ICRF-187 of acute daunorubicin toxicity in Syrian golden hamsters
-
Herman E.H., El-Hage A.N., Ferrans V.J., Witiak D.T. Reduction by ICRF-187 of acute daunorubicin toxicity in Syrian golden hamsters. Res Commun Pathol Pharmacol 1983, 40:217-231.
-
(1983)
Res Commun Pathol Pharmacol
, vol.40
, pp. 217-231
-
-
Herman, E.H.1
El-Hage, A.N.2
Ferrans, V.J.3
Witiak, D.T.4
-
14
-
-
0019352522
-
Reduction of chronic daunorubicin cardiotoxicity by ICRF-187 in rabbits
-
Herman E.H., Ferrans V.J., Jordan W., Ardalan B. Reduction of chronic daunorubicin cardiotoxicity by ICRF-187 in rabbits. Res Commun Chem Pathol Pharmacol 1981, 31:85-97.
-
(1981)
Res Commun Chem Pathol Pharmacol
, vol.31
, pp. 85-97
-
-
Herman, E.H.1
Ferrans, V.J.2
Jordan, W.3
Ardalan, B.4
-
15
-
-
0022620588
-
Pretreatment with ICRF-187 provides long lasting protection against chronic daunorubicin cardiotoxicity in rabbits
-
Herman E.H., Ferrans V.J. Pretreatment with ICRF-187 provides long lasting protection against chronic daunorubicin cardiotoxicity in rabbits. Cancer Chemother Pharmacol 1986, 16:102-106.
-
(1986)
Cancer Chemother Pharmacol
, vol.16
, pp. 102-106
-
-
Herman, E.H.1
Ferrans, V.J.2
-
16
-
-
0019518585
-
Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (+/-)-1,2-bis(3,5-dioxopiperazynl-1-propane (ICRF-187)
-
Herman E.H., Ferrans V.J. Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (+/-)-1,2-bis(3,5-dioxopiperazynl-1-propane (ICRF-187). Cancer Res 1981, 41:3436-3440.
-
(1981)
Cancer Res
, vol.41
, pp. 3436-3440
-
-
Herman, E.H.1
Ferrans, V.J.2
-
17
-
-
0021814289
-
Comparison of the severity of the chronic cardiac cardiotoxicity produced by doxorubicin in normotensive and hypertensive rats
-
Herman E.H., El-Hage A.N., Ferrans V.J., Ardalan B. Comparison of the severity of the chronic cardiac cardiotoxicity produced by doxorubicin in normotensive and hypertensive rats. Toxicol Appl Parmacol 1983, 78:202-214.
-
(1983)
Toxicol Appl Parmacol
, vol.78
, pp. 202-214
-
-
Herman, E.H.1
El-Hage, A.N.2
Ferrans, V.J.3
Ardalan, B.4
-
18
-
-
0023873326
-
Protective effect of ICRF-187 on doxorubicin-induced cardiac and renal toxicity in spontaneously hypertensive (SHR) and normotensive (WKY) rats
-
Herman E.H., El-Hage A.N., Ferrans V.J. Protective effect of ICRF-187 on doxorubicin-induced cardiac and renal toxicity in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Toxicol Appl Pharmacol 1988, 92:42-53.
-
(1988)
Toxicol Appl Pharmacol
, vol.92
, pp. 42-53
-
-
Herman, E.H.1
El-Hage, A.N.2
Ferrans, V.J.3
-
19
-
-
0027181374
-
Timing of treatment with ICRF-187 and its effect on chronic doxorubicin cardiotoxicity
-
Herman E.H., Ferrans V.J. Timing of treatment with ICRF-187 and its effect on chronic doxorubicin cardiotoxicity. Cancer Chemother Pharmacol 1993, 32:445-449.
-
(1993)
Cancer Chemother Pharmacol
, vol.32
, pp. 445-449
-
-
Herman, E.H.1
Ferrans, V.J.2
-
20
-
-
0024217559
-
Effect of pretreatment with ICRF-187 on the total cumulative dose of doxorubicin tolerated by beagle dogs
-
Herman E.H., Ferrans V.J., Young R.S., Hamlin R.L. Effect of pretreatment with ICRF-187 on the total cumulative dose of doxorubicin tolerated by beagle dogs. Cancer Res 1988, 48:6918-6925.
-
(1988)
Cancer Res
, vol.48
, pp. 6918-6925
-
-
Herman, E.H.1
Ferrans, V.J.2
Young, R.S.3
Hamlin, R.L.4
-
21
-
-
0023693833
-
Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiotoxicity in women with advanced breast cancer
-
Speyer J.L., Green M.D., Kramer E., et al. Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiotoxicity in women with advanced breast cancer. New Engl J Med 1988, 319:745-752.
-
(1988)
New Engl J Med
, vol.319
, pp. 745-752
-
-
Speyer, J.L.1
Green, M.D.2
Kramer, E.3
-
22
-
-
77957355941
-
Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long term follow-up
-
Lipshultz S.E., Scully R.E., Lipsitz S.R., et al. Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long term follow-up. Lancet Oncol 2010, 11:950-961.
-
(2010)
Lancet Oncol
, vol.11
, pp. 950-961
-
-
Lipshultz, S.E.1
Scully, R.E.2
Lipsitz, S.R.3
-
23
-
-
84866688380
-
Dexrazoxane for the prevention of cardiac toxicity and treatment of extravasation injury from the anthracycline antibiotics
-
Doroshow J.H. Dexrazoxane for the prevention of cardiac toxicity and treatment of extravasation injury from the anthracycline antibiotics. Curr Pharm Biotechnol 2012, 13:1949-1956.
-
(2012)
Curr Pharm Biotechnol
, vol.13
, pp. 1949-1956
-
-
Doroshow, J.H.1
-
24
-
-
0031974196
-
Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity
-
Herman E.H., Lipshultz S.E., Rifai N., et al. Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity. Cancer Res 1998, 58:1995-1997.
-
(1998)
Cancer Res
, vol.58
, pp. 1995-1997
-
-
Herman, E.H.1
Lipshultz, S.E.2
Rifai, N.3
-
25
-
-
0032983504
-
Correlation between the serum levels of cardiac troponin T and the severity of the chronic cardiomyopathy induced by doxorubicin
-
Herman E.H., Zhang J., Lipshultz S.E., et al. Correlation between the serum levels of cardiac troponin T and the severity of the chronic cardiomyopathy induced by doxorubicin. J Clin Oncol 1999, 17:2237-2243.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2237-2243
-
-
Herman, E.H.1
Zhang, J.2
Lipshultz, S.E.3
-
26
-
-
0033817796
-
Treatment of anthracycline extravasation with dexrazoxane
-
Langer S.W., Sehested M., Jensen P.B. Treatment of anthracycline extravasation with dexrazoxane. Clin Cancer Res 2000, 6:3680-3686.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3680-3686
-
-
Langer, S.W.1
Sehested, M.2
Jensen, P.B.3
-
28
-
-
33847662074
-
Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies
-
Mouridsen H.T., Langer S.W., Buter J., et al. Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies. Ann Oncol 2007, 18:546-550.
-
(2007)
Ann Oncol
, vol.18
, pp. 546-550
-
-
Mouridsen, H.T.1
Langer, S.W.2
Buter, J.3
-
29
-
-
39049089593
-
The use of dexrazoxane for the prevention of anthracycline extravasation injury
-
Hasinoff B.B. The use of dexrazoxane for the prevention of anthracycline extravasation injury. Expert Opin Investig Drugs 2008, 17:217-223.
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 217-223
-
-
Hasinoff, B.B.1
-
30
-
-
0022573323
-
Mechanism of the protective activity of ICRF-187 against alloxan-induced diabetes in mice
-
El Hage A., Herman E.H., Yang G.C., Crouch R.K., Ferrans V.J. Mechanism of the protective activity of ICRF-187 against alloxan-induced diabetes in mice. Res Commun Pathol Pharmacol 1986, 52:341-360.
-
(1986)
Res Commun Pathol Pharmacol
, vol.52
, pp. 341-360
-
-
El Hage, A.1
Herman, E.H.2
Yang, G.C.3
Crouch, R.K.4
Ferrans, V.J.5
-
31
-
-
0021084131
-
Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters
-
El-Hage A.N., Herman E.H., Ferrans V.J. Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters. Toxicology 1983, 28:295-303.
-
(1983)
Toxicology
, vol.28
, pp. 295-303
-
-
El-Hage, A.N.1
Herman, E.H.2
Ferrans, V.J.3
-
32
-
-
0026701351
-
Effect of ICRF-187 on the pulmonary damage induced by hypoxia in the rat
-
Fukuda Y., Herman E.H., Ferrans V.J. Effect of ICRF-187 on the pulmonary damage induced by hypoxia in the rat. Toxicology 1992, 74:186-202.
-
(1992)
Toxicology
, vol.74
, pp. 186-202
-
-
Fukuda, Y.1
Herman, E.H.2
Ferrans, V.J.3
-
33
-
-
0028915312
-
Morphologic and morphometric evaluation of the effect of ICRF-187 on bleomycin-induced pulmonary toxicity
-
Herman E.H., Hasinoff B.B., Zhang J., et al. Morphologic and morphometric evaluation of the effect of ICRF-187 on bleomycin-induced pulmonary toxicity. Toxicology 1995, 98:163-175.
-
(1995)
Toxicology
, vol.98
, pp. 163-175
-
-
Herman, E.H.1
Hasinoff, B.B.2
Zhang, J.3
-
34
-
-
34548299563
-
Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?
-
Hasinoff B.B., Herman E.H. Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?. Cardiovasc Toxicol 2007, 7:140-144.
-
(2007)
Cardiovasc Toxicol
, vol.7
, pp. 140-144
-
-
Hasinoff, B.B.1
Herman, E.H.2
-
35
-
-
84926130100
-
The pharmacology of dexrazoxane: iron chelating prodrug and topoisomerase II inhibitor
-
Springer, Dordrecht, K. Hellmann, W. Rhomberg (Eds.)
-
Hasinoff B.B. The pharmacology of dexrazoxane: iron chelating prodrug and topoisomerase II inhibitor. Razoxane and Dexrazoxane-Two Multifunctional Agents 2010, 158-167. Springer, Dordrecht. K. Hellmann, W. Rhomberg (Eds.).
-
(2010)
Razoxane and Dexrazoxane-Two Multifunctional Agents
, pp. 158-167
-
-
Hasinoff, B.B.1
-
36
-
-
39049089593
-
The use of dexrazoxane for the prevention of anthracycline extravasation injury
-
Hasinoff B.B. The use of dexrazoxane for the prevention of anthracycline extravasation injury. Expert Opin Investig Drugs 2008, 17:217-223.
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 217-223
-
-
Hasinoff, B.B.1
-
37
-
-
0028810791
-
A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane)
-
Hasinoff B.B., Kuschak T.I., Yalowich J.C., Creighton A.M. A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane). Biochem Pharmacol 1995, 50:953-958.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 953-958
-
-
Hasinoff, B.B.1
Kuschak, T.I.2
Yalowich, J.C.3
Creighton, A.M.4
-
38
-
-
84891511978
-
A high-throughput fluorescence anisotropy-based assay for human topoisomerase II beta-catalyzed ATP-dependent supercoiled DNA relaxation
-
Shapiro A.B., Austin C.A. A high-throughput fluorescence anisotropy-based assay for human topoisomerase II beta-catalyzed ATP-dependent supercoiled DNA relaxation. Anal Biochem 2014, 448:23-29.
-
(2014)
Anal Biochem
, vol.448
, pp. 23-29
-
-
Shapiro, A.B.1
Austin, C.A.2
-
39
-
-
0031906718
-
Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines
-
Hasinoff B.B., Hellmann K., Herman E.H., Ferrans V.J. Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines. Curr Med Chem 1998, 5:1-28.
-
(1998)
Curr Med Chem
, vol.5
, pp. 1-28
-
-
Hasinoff, B.B.1
Hellmann, K.2
Herman, E.H.3
Ferrans, V.J.4
-
40
-
-
34548785032
-
Topoisomerase IIβ mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane
-
Lyu Y.L., Kerrigan J.E., Lin C.P., et al. Topoisomerase IIβ mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane. Cancer Res 2007, 67:8839-8846.
-
(2007)
Cancer Res
, vol.67
, pp. 8839-8846
-
-
Lyu, Y.L.1
Kerrigan, J.E.2
Lin, C.P.3
-
41
-
-
84891009434
-
Topoisomerase 2β: a promising molecular target for primary prevention of anthracycline-induced cardiotoxicity
-
Vejpongsa P., Yeh E.T. Topoisomerase 2β: a promising molecular target for primary prevention of anthracycline-induced cardiotoxicity. Clin Pharmacol Ther 2014, 95:45-52.
-
(2014)
Clin Pharmacol Ther
, vol.95
, pp. 45-52
-
-
Vejpongsa, P.1
Yeh, E.T.2
-
42
-
-
84869209094
-
Identification of the molecular basis of doxorubicin-induced cardiotoxicity
-
Zhang S., Liu X., Bawa-Khalfe T., et al. Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med 2012, 18:1639-1642.
-
(2012)
Nat Med
, vol.18
, pp. 1639-1642
-
-
Zhang, S.1
Liu, X.2
Bawa-Khalfe, T.3
-
43
-
-
0016775708
-
Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells
-
Dawson K.M. Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells. Biochem Pharmacol 1975, 24:2249-2253.
-
(1975)
Biochem Pharmacol
, vol.24
, pp. 2249-2253
-
-
Dawson, K.M.1
-
44
-
-
0034136253
-
Iron complexes of the cardioprotective agent dexrazoxane (ICRF-187) and its desmethyl derivative, ICRF-154: solid state structure, solution thermodynamics, and DNA cleavage activity
-
Diop N.K., Vitellaro L.K., Arnold P., Shang M., Marusak R.A. Iron complexes of the cardioprotective agent dexrazoxane (ICRF-187) and its desmethyl derivative, ICRF-154: solid state structure, solution thermodynamics, and DNA cleavage activity. J Inorg Biochem 2000, 78:209-216.
-
(2000)
J Inorg Biochem
, vol.78
, pp. 209-216
-
-
Diop, N.K.1
Vitellaro, L.K.2
Arnold, P.3
Shang, M.4
Marusak, R.A.5
-
45
-
-
0041854306
-
The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity
-
Hasinoff B.B., Schroeder P.E., Patel D. The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity. Mol Pharmacol 2003, 64:670-678.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 670-678
-
-
Hasinoff, B.B.1
Schroeder, P.E.2
Patel, D.3
-
46
-
-
0036363028
-
Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxia-reoxygenation damage
-
Hasinoff B.B. Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxia-reoxygenation damage. Cardiovasc Toxicol 2002, 2:111-118.
-
(2002)
Cardiovasc Toxicol
, vol.2
, pp. 111-118
-
-
Hasinoff, B.B.1
-
47
-
-
0027740137
-
The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes
-
Buss J.L., Hasinoff B.B. The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes. Agents Actions 1993, 40:86-95.
-
(1993)
Agents Actions
, vol.40
, pp. 86-95
-
-
Buss, J.L.1
Hasinoff, B.B.2
-
48
-
-
0033628701
-
Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice
-
Fortune J.M., Osheroff N. Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Prog Nucleic Acid Res Mol Biol 2000, 64:221-253.
-
(2000)
Prog Nucleic Acid Res Mol Biol
, vol.64
, pp. 221-253
-
-
Fortune, J.M.1
Osheroff, N.2
-
49
-
-
0033006172
-
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
-
Gewirtz D.A. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol 1999, 57:727-741.
-
(1999)
Biochem Pharmacol
, vol.57
, pp. 727-741
-
-
Gewirtz, D.A.1
-
50
-
-
77954187741
-
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
-
Pommier Y., Leo E., Zhang H., Marchand C. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol 2010, 17:421-433.
-
(2010)
Chem Biol
, vol.17
, pp. 421-433
-
-
Pommier, Y.1
Leo, E.2
Zhang, H.3
Marchand, C.4
-
51
-
-
0034075866
-
Localization of dichlorofluorescein in cardiac myocytes: implications for assessment of oxidative stress
-
Swift L.M., Sarvazyan N. Localization of dichlorofluorescein in cardiac myocytes: implications for assessment of oxidative stress. Am J Physiol Heart Circ Physiol 2000, 278:H982-H990.
-
(2000)
Am J Physiol Heart Circ Physiol
, vol.278
, pp. H982-H990
-
-
Swift, L.M.1
Sarvazyan, N.2
-
52
-
-
0642280672
-
Dexrazoxane (ICRF-187) protects cardiac myocytes against doxorubicin by preventing damage to mitochondria
-
Hasinoff B.B., Schnabl K.L., Marusak R.A., Patel D., Huebner E. Dexrazoxane (ICRF-187) protects cardiac myocytes against doxorubicin by preventing damage to mitochondria. Cardiovasc Toxicol 2003, 3:89-99.
-
(2003)
Cardiovasc Toxicol
, vol.3
, pp. 89-99
-
-
Hasinoff, B.B.1
Schnabl, K.L.2
Marusak, R.A.3
Patel, D.4
Huebner, E.5
-
53
-
-
33750688601
-
Visualization of doxorubicin-induced oxidative stress in isolated cardiac myocytes
-
Sarvazyan N. Visualization of doxorubicin-induced oxidative stress in isolated cardiac myocytes. Am J Physiol 1996, 271:H2079-H2085.
-
(1996)
Am J Physiol
, vol.271
, pp. H2079-H2085
-
-
Sarvazyan, N.1
-
54
-
-
0038596403
-
Hydroxyl radical production by the iron complex of the hydrolysis product of the antioxidant cardioprotective agent ICRF-187 (dexrazoxane)
-
Malisza K.L., Hasinoff B.B. Hydroxyl radical production by the iron complex of the hydrolysis product of the antioxidant cardioprotective agent ICRF-187 (dexrazoxane). Redox Rep 1996, 2:69-73.
-
(1996)
Redox Rep
, vol.2
, pp. 69-73
-
-
Malisza, K.L.1
Hasinoff, B.B.2
-
55
-
-
0042830919
-
Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide
-
Schroeder P.E., Jensen P.B., Sehested M., Hofland K.F., Langer S.W., Hasinoff B.B. Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide. Cancer Chemother Pharmacol 2003, 52:167-174.
-
(2003)
Cancer Chemother Pharmacol
, vol.52
, pp. 167-174
-
-
Schroeder, P.E.1
Jensen, P.B.2
Sehested, M.3
Hofland, K.F.4
Langer, S.W.5
Hasinoff, B.B.6
-
56
-
-
1842866539
-
Dihydroorotase catalyzes the ring-opening of the hydrolysis intermediates of the cardioprotective drug dexrazoxane (ICRF-187)
-
Schroeder P.E., Davidson J.N., Hasinoff B.B. Dihydroorotase catalyzes the ring-opening of the hydrolysis intermediates of the cardioprotective drug dexrazoxane (ICRF-187). Drug Metab Dispos 2002, 30:1431-1435.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 1431-1435
-
-
Schroeder, P.E.1
Davidson, J.N.2
Hasinoff, B.B.3
-
57
-
-
18844435708
-
Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes and by blood
-
Schroeder P.E., Wang G.Q., Burczynski F.J., Hasinoff B.B. Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes and by blood. Drug Metab Dispos 2005, 33:719-725.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 719-725
-
-
Schroeder, P.E.1
Wang, G.Q.2
Burczynski, F.J.3
Hasinoff, B.B.4
-
58
-
-
23944434434
-
Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal chelating form in the rat
-
Schroeder P.E., Hasinoff B.B. Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal chelating form in the rat. Drug Metab Dispos 2005, 33:1367-1372.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 1367-1372
-
-
Schroeder, P.E.1
Hasinoff, B.B.2
-
59
-
-
50049129357
-
The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites
-
Schroeder P.E., Patel D., Hasinoff B.B. The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites. Drug Metab Dispos 2008, 36:1780-1785.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 1780-1785
-
-
Schroeder, P.E.1
Patel, D.2
Hasinoff, B.B.3
-
60
-
-
63349086953
-
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing
-
Deweese J.E., Osheroff N. The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res 2009, 37:738-748.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 738-748
-
-
Deweese, J.E.1
Osheroff, N.2
-
61
-
-
64649090292
-
Targeting DNA, topoisomerase II in cancer chemotherapy
-
Nitiss J.L. Targeting DNA, topoisomerase II in cancer chemotherapy. Nat Rev Cancer 2009, 9:338-350.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 338-350
-
-
Nitiss, J.L.1
-
62
-
-
0141591551
-
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187
-
Classen S., Olland S., Berger J.M. Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A 2003, 100:14510.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 14510
-
-
Classen, S.1
Olland, S.2
Berger, J.M.3
-
63
-
-
0141591551
-
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187
-
Classen S., Olland S., Berger J.M. Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A 2003, 100:10629-10634.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 10629-10634
-
-
Classen, S.1
Olland, S.2
Berger, J.M.3
-
64
-
-
84855347756
-
Interfacial inhibitors: targeting macromolecular complexes
-
Pommier Y., Marchand C. Interfacial inhibitors: targeting macromolecular complexes. Nat Rev Drug Discov 2012, 11:25-36.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 25-36
-
-
Pommier, Y.1
Marchand, C.2
-
65
-
-
84872547120
-
Drugging topoisomerases: lessons and challenges
-
Pommier Y. Drugging topoisomerases: lessons and challenges. ACS Chem Biol 2013, 8:82-95.
-
(2013)
ACS Chem Biol
, vol.8
, pp. 82-95
-
-
Pommier, Y.1
-
66
-
-
0742269397
-
The current and future role of dexrazoxane as a cardioprotectant in anthracycline treatment: expert panel review
-
Swain S.M., Vici P. The current and future role of dexrazoxane as a cardioprotectant in anthracycline treatment: expert panel review. J Cancer Res Clin Oncol 2004, 130:1-7.
-
(2004)
J Cancer Res Clin Oncol
, vol.130
, pp. 1-7
-
-
Swain, S.M.1
Vici, P.2
-
67
-
-
57449120634
-
Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy
-
Martin E., Thougaard A.V., Grauslund M., et al. Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy. Toxicology 2009, 255:72-79.
-
(2009)
Toxicology
, vol.255
, pp. 72-79
-
-
Martin, E.1
Thougaard, A.V.2
Grauslund, M.3
-
68
-
-
0021812284
-
Comparison of the protective effect of ICRF-187 and structurally related analogues against acute daunorubicin toxicity in Syrian golden hamsters
-
Herman E.H., El-Hage A.N., Creighton A.M., Witiak D.T., Ferrans V.J. Comparison of the protective effect of ICRF-187 and structurally related analogues against acute daunorubicin toxicity in Syrian golden hamsters. Res Commun Chem Pathol Pharmacol 1985, 48:39-55.
-
(1985)
Res Commun Chem Pathol Pharmacol
, vol.48
, pp. 39-55
-
-
Herman, E.H.1
El-Hage, A.N.2
Creighton, A.M.3
Witiak, D.T.4
Ferrans, V.J.5
|