Iron complexes of the cardioprotective agent dexrazoxane (ICRF-187) and its desmethyl derivative, ICRF-154: Solid state structure, solution thermodynamics, and DNA cleavage activity

Journal of Inorganic Biochemistry

Volumn 78, Issue 3, 2000, Pages 209-216

  Diop, Ndeye Khady ^a   Vitellaro, Lizabeth K ^a   Arnold, Paul ^a   Shang, Maoyu ^b   Marusak, Rosemary A ^a  

^a KENYON COLLEGE   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

ADR 925; Dexrazoxane; DNA cleavage; ICRF 154; Iron chelates

Indexed keywords

1,2 BIS(3,5 DIOXOPIPERAZIN 1 YL)ETHANE; 1,2-BIS(3,5-DIOXOPIPERAZIN-1-YL)ETHANE; CARDIOVASCULAR AGENT; DNA; DRUG DERIVATIVE; IRON; RAZOXANE; 1,2 PROPANEDIAMINE N,N' DIACETAMIDE N,N' DIACETIC ACID; EDETATE IRON; EDETIC ACID; HYDROXYL RADICAL; ICRF 247; IRON COMPLEX; OXIDIZING AGENT; PROTECTIVE AGENT; REDUCING AGENT; SODIUM BROMIDE; SODIUM NITRATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLUTION AND SOLUBILITY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY; AQUEOUS SOLUTION; COMPLEX FORMATION; DIMERIZATION; DISSOCIATION CONSTANT; DNA CLEAVAGE; DRUG STRUCTURE; HEART PROTECTION; IRON CHELATION; MOLECULAR STABILITY; PH; PKA; POTENTIOMETRY; SOLID STATE;

CARDIOVASCULAR AGENTS; CRYSTALLOGRAPHY, X-RAY; DNA; HYDROLYSIS; IRON; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; RAZOXANE; SOLUTIONS; THERMODYNAMICS;

EID: 0034136253     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-0134(00)00013-1     Document Type: Article

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