Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 13, 2015, Pages 4074-4079

  McClellan, James Scott ^a   Dove, Christopher ^a   Gentles, Andrew J ^a   Ryan, Christine E ^a   Majeti, Ravindra ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute lymphoblastic leukemia; CCAAT enhancer binding protein alpha; Ineage reprogramming; Macrophage; Transdifferentiation

Indexed keywords

BCR ABL PROTEIN; CCAAT ENHANCER BINDING PROTEIN; CD14 ANTIGEN; CELL SURFACE MARKER; REACTIVE OXYGEN METABOLITE; BCR-ABL1 FUSION PROTEIN, HUMAN; CD19 ANTIGEN; CYTOKINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; DOWN REGULATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE FUNCTION; HUMAN; IMMUNOPHENOTYPING; IN VITRO STUDY; LEUKEMIA CELL; MACROPHAGE; MYELOID PROGENITOR CELL; NONHUMAN; NUCLEAR REPROGRAMMING; PHILADELPHIA CHROMOSOME POSITIVE CELL; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSIENT EXPRESSION; UPREGULATION; ADULT; AGED; ANIMAL; B LYMPHOCYTE; CULTURE TECHNIQUE; CYTOLOGY; FEMALE; GENETICS; LEUKOCYTE; MALE; METABOLISM; MIDDLE AGED; MOUSE; PHILADELPHIA 1 CHROMOSOME; PROGNOSIS; TRANSGENIC MOUSE;

ADULT; AGED; ANIMALS; ANTIGENS, CD14; ANTIGENS, CD19; B-LYMPHOCYTES; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CYTOKINES; FEMALE; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKOCYTES; MACROPHAGES; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; PHILADELPHIA CHROMOSOME; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS;

EID: 84926028060     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1413383112     Document Type: Article

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