Spontaneous calcification process in primary renal cells from a medullary sponge kidney patient harbouring a GDNF mutation

Journal of Cellular and Molecular Medicine

Volumn 19, Issue 4, 2015, Pages 889-902

  Mezzabotta, Federica ^a   Cristofaro, Rosalba ^a   Ceol, Monica ^a   Del Prete, Dorella ^a   Priante, Giovanna ^a   Familiari, Alessandra ^a   Fabris, Antonia ^b   D'Angelo, Angela ^a   Gambaro, Giovanni ^c   Anglani, Franca ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY HOSPITAL OF VERONA   (Italy)

^c FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

GDNF; Medullary sponge kidney; Mesenchymal stromal stem cells; Nephrocalcinosis

Indexed keywords

ACTIN; CD146 ANTIGEN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; OSTEONECTIN; OSTEOPONTIN; PROTEIN ZO1; TJP1 PROTEIN, HUMAN; VIMENTIN;

AGED; BONE MINERALIZATION; CALCINOSIS; CELL CULTURE; CELL LINE; CHEMISTRY; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; KIDNEY; MEDULLARY SPONGE KIDNEY; METABOLISM; MIDDLE AGED; MUTATION; PATHOLOGY; PRIMARY CELL CULTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SCANNING ELECTRON MICROSCOPY; SMOOTH MUSCLE; ULTRASTRUCTURE;

ACTINS; AGED; ANTIGENS, CD146; CALCIFICATION, PHYSIOLOGIC; CALCINOSIS; CELL LINE; CELLS, CULTURED; FEMALE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; MEDULLARY SPONGE KIDNEY; MICROSCOPY, ELECTRON, SCANNING; MIDDLE AGED; MUSCLE, SMOOTH; MUTATION; OSTEONECTIN; OSTEOPONTIN; PRIMARY CELL CULTURE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; VIMENTIN; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84925969453     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12514     Document Type: Article

References (32)

1. Vervaet BA, Verhulst A, D'Haese PC, et al. Nephrocalcinosis: new insights into mechanisms and consequences. Nephrol Dial Transplant Rev. 2009; 24: 2030-5.
2. Sayer JA, Carr G, Simmons NL. Nephrocalcinosis: molecular insights into calcium precipitation within the kidney. Clin Sci (Lond). 2004; 106: 549-61.
3. Bushinsky DA. Nephrolithiasis: site of the initial solid phase. J Clin Invest. 2003; 111: 602-5.
4. Gambaro G, D'Angelo A, Fabris A, et al. Crystals, Randall's plaques and renal stones: do bone and atherosclerosis teach us something? J Nephrol. 2004; 17: 774-7.
5. Miyazawa K, Aihara K, Ikeda R, et al. cDNA macroarray analysis of genes in renal epithelial cells exposed to calcium oxalate crystals. Urol Res. 2009; 37: 27-33.
6. Peerapen P, Thongboonkerd V. Effects of calcium oxalate monohydrate crystals on expression and function of tight junction of renal tubular epithelial cells. Lab Invest. 2011; 91: 97-105.
7. Kumar V, Farell G, Yu S, et al. Cell biology of pathologic renal calcification: contribution of crystal transcytosis, cell-mediated calcification, and nanoparticles. J Investig Med. 2006; 54: 412-24.
8. Gambaro G, Fabris A, Citron L, et al. An unusual association of contralateral congenital small kidney, reduced renal function and hyperparathyroidism in sponge kidney patients: on the track of the molecular basis. Nephrol Dial Transplant. 2005; 20: 1042-7.
9. Torregrossa R, Anglani F, Fabris A, et al. Identification of GDNF gene sequence variations in patients with medullary sponge kidney disease. Clin J Am Soc Nephrol. 2010; 5: 1205-10.
10. Meloan SN, Puchtler H. Chemical mechanisms of staining methods: von Kossa's technique. What von Kossa really wrote and a modified reaction for selective demonstration of inorganic phosphate. J Histotechol. 1985; 8: 11-3.
11. Forino M, Torregrossa R, Ceol M, et al. TGFbeta1 induces epithelial-mesenchymal transition, but not myofibroblast transdifferentiation of human kidney tubular epithelial cells in primary culture. Int J Exp Pathol. 2006; 87: 197-208.
12. + cells, metabolic syndrome, and cardiovascular risk. Eur Heart J. 2006; 27: 2247-55.
13. Conconi MT, De Coppi P, Di Liddo R, et al. Tracheal matrices, obtained by a detergent-enzymatic method, support in vitro the adhesion of chondrocytes and tracheal epithelial cells. Transpl Int. 2005; 18: 727-34.
14. Ceol M, Forino M, Gambaro G, et al. Quantitation of TGF-beta1 mRNA in porcine mesangial cells by comparative kinetic RT/PCR: comparison with ribonuclease protection assay and in situ hybridization. J Clin Lab Anal. 2001; 15: 215-22.
15. Huggett J, Dheda K, Bustin S, et al. Real-time RT-PCR normalisation; strategies and considerations. Genes Immun. 2005; 6: 279-84.
16. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data bygeometric averaging of multiple internal control genes. Genome Biol. 2002; 3: research0034.
17. Kirkham GR, Cartmell SH. Genes and proteins involved in the regulation of osteogenesis. In: Ashammakhi N, Reis R, Chiellini E, editors. Topics in tissue engineering (vol 3, Chapter 13). 2007. pp. 1-22.
18. Wesson JA, Johnson RJ, Mazzali M, et al. Osteopontin is a critical inhibitor of calcium oxalate crystal formation and retention in renal tubules. J Am Soc Nephrol. 2003; 14: 139-47.
19. McKe MD, Nanci A, Khan SR. Ultrastructural immunodetection of osteopontin and osteocalcin as major matrix components of renal calculi. J Bone Miner Res. 1995; 10: 1913-29.
20. Hoyer JR, Asplin JR, Otvos L. Phosphorylated osteopontin peptides suppress crystallization by inhibiting the growth of calcium oxalate crystals. Kidney Int. 2001; 60: 77-82.
21. Cohen MM. Perspectives on RUNX genes: an update. Am J Med Genet. 2009; 149: 2629-46.
22. Jensen ED, Gopalakrishnan R, Westendorf JJ. Regulation of gene expression in osteoblasts. BioFactors. 2010; 36: 25-32.
23. Schor AM, Allen TD, Canfield AE, et al. Pericytes derived from the retinal microvasculature undergo calcification in vitro. J Cell Sci. 1990; 97: 449-61.
24. Iyemere VP, Proudfoot D, Weissberg PL. Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification. J Intern Med. 2006; 260: 192-210.
25. Majors AK, Boehm CA, Nitto H, et al. Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation. J Orthop Res. 1997; 15: 546-57.
26. Crisan M, Yap S, Casteilla L, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell. 2008; 3: 301-13.
27. Ward HH, Romero E, Welford A, et al. Adult human CD133/1(+) kidney cells isolated from papilla integrate into developing kidney tubules. Biochim Biophys Acta. 2011; 1812: 1344-57.
28. + progenitors through Oct4/miR-145 balance. Am J Physiol Renal Physiol. 2012; 30: 116-28.
29. Anglani F, Mezzabotta F, Ceol M, et al. The regenerative potential of the kidney: what can we learn from developmental biology? Stem Cell Rev. 2010; 6: 650-7.
30. Pallone TL, Silldorff EP. Pericyte regulation of renal medullary blood flow. Exp Nephrol. 2001; 9: 165-70.
31. Tovar-Y-Romo LB, Ramírez-Jarquín UN, Lazo-Gómez R, et al. Trophic factors as modulators of motor neuron physiology and survival: implications for ALS therapy. Front Cell Neurosci. 2014; 8: 61.
32. Tsui CC, Shankland SJ, Pierchala BA. Glial cell line-derived neurotrophic factor and its receptor ret is a novel ligand-receptor complex critical for survival response during podocyte injury. J Am Soc Nephrol. 2006; 17: 1543-52.