Nephrocalcinosis: New insights into mechanisms and consequences

Nephrology Dialysis Transplantation

Volumn 24, Issue 7, 2009, Pages 2030-2035

  Vervaet, Benjamin A ^a   Verhulst, Anja ^a   D'Haese, Patrick C ^a   De Broe, Marc E ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Crystal formation; Crystal retention; Nephrocalcinosis; Nephrolithiasis; Randall's plaque

Indexed keywords

CAUSAL ATTRIBUTION; HUMAN; KIDNEY CALCIFICATION; KIDNEY INTERSTITIUM; KIDNEY TUBULE DISORDER; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

HUMANS; KIDNEY TUBULES; NEPHROCALCINOSIS;

EID: 67651096037     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp115     Document Type: Review

References (76)

1. Asplin JR, Parks JH, Coe FL. Dependence of upper limit of metastability on supersaturation in nephrolithiasis. Kidney Int 1997; 52: 1602-1608
2. Kok DJ. Crystallization and stone formation inside the nephron. Scanning Microsc 1996; 10: 471-484
3. Ryall RL, Fleming DE, Grover PK et al. The hole truth: intracrystalline proteins and calcium oxalate kidney stones. Mol Urol 2000; 4: 391-402
4. Ryall RL. Macromolecules and urolithiasis: parallels and paradoxes. Nephron Physiol 2004; 98: 37-42
5. Asselman M, Verhulst A, De Broe ME et al. Calcium oxalate crystal adherence to hyaluronan-, osteopontin-, and CD44-expressing injured/regenerating tubular epithelial cells in rat kidneys. J Am Soc Nephrol 2003; 14: 3155-3166
6. Verhulst A, Asselman M, Persy VP et al. Crystal retention capacity of cells in the human nephron: involvement of CD44 and its ligands hyaluronic acid and osteopontin in the transition of a crystal binding-into a nonadherent epithelium. J Am Soc Nephrol 2003; 14: 107-115
7. Verkoelen CF, Van Der Boom BG, Romijn JC. Identification of hyaluronan as a crystal-binding molecule at the surface of migrating and proliferating MDCK cells. Kidney Int 2000; 58: 1045-1054
8. Verkoelen CF, Van Der Boom BG, Houtsmuller AB et al. Increased calcium oxalate monohydrate crystal binding to injured renal tubular epithelial cells in culture. Am J Physiol 1998; 274: F958-F965
9. Verkoelen CF, Van Der Boom BG, Kok DJ et al. Cell type-specific acquired protection from crystal adherence by renal tubule cells in culture. Kidney Int 1999; 55: 1426-1433
10. Kumar V, Pena dl, V, Farell G et al. Urinary macromolecular inhibition of crystal adhesion to renal epithelial cells is impaired in male stone formers. Kidney Int 2005; 68: 1784-1792
11. Mo L, Huang HY, Zhu XH et al. Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation. Kidney Int 2004; 66: 1159-1166
12. Worcester EM. Inhibitors of stone formation. Semin Nephrol 1996; 16: 474-486
13. De Yoreo JJ, Qiu SR, Hoyer JR. Molecular modulation of calcium oxalate crystallization. Am J Physiol Renal Physiol 2006; 291: F1123-F1131
14. Hebert SC. Extracellular calcium-sensing receptor: implications for calcium and magnesium handling in the kidney. Kidney Int 1996; 50: 2129-2139
15. Hebert SC, Brown EM, Harris HW. Role of the Ca(2+)-sensing receptor in divalent mineral ion homeostasis. JExpBiol 1997; 200: 295-302
16. Verhulst A, Asselman M, De Naeyer S et al. Preconditioning of the distal tubular epithelium of the human kidney precedes nephrocalcinosis. Kidney Int 2005; 68: 1643-1647
17. Wiessner JH, Hasegawa AT, Hung LY et al. Mechanisms of calcium oxalate crystal attachment to injured renal collecting duct cells. Kidney Int 2001; 59: 637-644
18. Asselman M, Verkoelen CF. Crystal-cell interaction in the pathogenesis of kidney stone disease. Curr Opin Urol 2002; 12: 271-276
19. Asselman M, Verhulst A, Van Ballegooijen ES et al. Hyaluronan is apically secreted and expressed by proliferating or regenerating renal tubular cells. Kidney Int 2005; 68: 71-83
20. Carr G, Simmons NL, Sayer JA. Disruption of clc-5 leads to a redistribution of annexin A2 and promotes calcium crystal agglomeration in collecting duct epithelial cells. Cell Mol Life Sci 2006; 63: 367-377
21. Khan SR, Shevock PN, Hackett RL. Acute hyperoxaluria, renal injury and calcium oxalate urolithiasis. JUrol 1992; 147: 226-230
22. Kumar V, Farell G, Deganello S et al. Annexin II is present on renal epithelial cells and binds calcium oxalate monohydrate crystals. JAm Soc Nephrol 2003; 14: 289-297
23. Sorokina EA, Wesson JA, Kleinman JG. An acidic peptide sequence of nucleolin-related protein can mediate the attachment of calcium oxalate to renal tubule cells. J Am Soc Nephrol 2004; 15: 2057-2065
24. Riese RJ, Mandel NS, Wiessner JH et al. Cell polarity and calcium oxalate crystal adherence to cultured collecting duct cells. Am J Physiol 1992; 262: F177-F184
25. Lieske JC, Toback FG, Deganello S. Sialic acid-containing glycoproteins on renal cells determine nucleation of calcium oxalate dihydrate crystals. Kidney Int 2001; 60: 1784-1791
26. Bigelow MW, Wiessner JH, Kleinman JG et al. Surface exposure of phosphatidylserine increases calcium oxalate crystal attachment to IMCD cells. Am J Physiol 1997; 272: F55-F62
27. Riese RJ, Riese JW, Kleinman JG et al. Specificity in calcium oxalate adherence to papillary epithelial cells in cultures. Am J Physiol 1988; 255: F1025-F1032
28. Schepers MS, Duim RA, Asselman M et al. Internalization of calcium oxalate crystals by renal tubular cells: a nephron segment-specific process? Kidney Int 2003; 64: 493-500
29. Schepers MS, Van Ballegooijen ES, Bangma CH et al. Crystals cause acute necrotic cell death in renal proximal tubule cells, but not in collecting tubule cells. Kidney Int 2005; 68: 1543-1553
30. Gambaro G, Valente ML, Zanetti E et al. Mild tubular damage induces calcium oxalate crystalluria in a model of subtle hyperoxaluria: evidence that a second hit is necessary for renal lithogenesis. JAm Soc Nephrol 2006; 17: 2213-2219
31. Schell-Feith EA, Kist-Van Holthe JE, Conneman N et al. Etiology of nephrocalcinosis in preterm neonates: association of nutritional intake and urinary parameters. Kidney Int 2000; 58: 2102-2110
32. Schell-Feith EA, Kist-Van Holthe JE, van Zwieten PH et al. Preterm neonates with nephrocalcinosis: natural course and renal function. Pediatr Nephrol 2003; 18: 1102-1108
33. Evan AP, Lingeman JE, Coe FL et al. Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. J Clin Invest 2003; 111: 607-616
34. Vervaet BA, Verhulst A, Dauwe SE et al. An active renal crystal clearance mechanism in rat and man. Kidney Int 2008; 75: 41-51
35. Marengo SR, Chen DH, Evan AP et al. Continuous infusion of oxalate by minipumps induces calcium oxalate nephrocalcinosis. Urol Res 2006; 34: 200-210
36. Guo C, McMartin KE. The cytotoxicity of oxalate, metabolite of ethylene glycol, is due to calcium oxalate monohydrate formation. Toxicology 2005; 208: 347-355
37. Schepers MS, Van Ballegooijen ES, Bangma CH et al. Oxalate is toxic to renal tubular cells only at supraphysiologic concentrations. Kidney Int 2005; 68: 1660-1669
38. Sarica K, Erbagci A, Yagci F et al. Limitation of apoptotic changes in renal tubular cell injury induced by hyperoxaluria. Urol Res 2004; 32: 271-277
39. Khan SR. Calcium oxalate crystal interaction with renal tubular epithelium, mechanism of crystal adhesion and its impact on stone development. Urol Res 1995; 23: 71-79
40. Verkoelen CF, Van Der Boom BG, Kok DJ et al. Sialic acid and crystal binding. Kidney Int 2000; 57: 1072-1082
41. Chevalier RL. Pathogenesis of renal injury in obstructive uropathy. Curr Opin Pediatr 2006; 18: 153-160
42. Bani-Hani AH, Campbell MT, Meldrum DR et al. Cytokines in epithelial-mesenchymal transition: a new insight into obstructive nephropathy. JUrol 2008; 180: 461-468
43. Markowitz GS, Nasr SH, Klein P et al. Renal failure due to acute nephrocalcinosis following oral sodium phosphate bowel cleansing. Hum Pathol 2004; 35: 675-684
44. Worcester E, Evan A, Bledsoe S et al. Pathophysiological correlates of two unique renal tubule lesions in rats with intestinal resection. Am J Physiol Renal Physiol 2006; 291: F1061-F1069
45. Yarlagadda SG, Perazella MA. Drug-induced crystal nephropathy: an update. Expert Opin Drug Saf 2008; 7: 147-158
46. Perazella MA. Crystal-induced acute renal failure. Am J Med 1999; 106: 459-465
47. Evan AE, Lingeman JE, Coe FL et al. Histopathology and surgical anatomy of patients with primary hyperparathyroidism and calcium phosphate stones. Kidney Int 2008; 74: 223-229
48. Evan AP, Lingeman JE, Coe FL et al. Crystal-associated nephropathy in patients with brushite nephrolithiasis. Kidney Int 2005; 67: 576-591
49. Evan AP, Lingeman J, Coe F et al. Renal histopathology of stone-forming patients with distal renal tubular acidosis. Kidney Int 2007; 71: 795-801
50. Evan AP, Coe FL, Lingeman JE et al. Renal crystal deposits and histopathology in patients with cystine stones. Kidney Int 2006; 69: 2227-2235
51. Escobar C, Byer KJ, Khaskheli H et al. Apatite induced renal epithelial injury: insight into the pathogenesis of kidney stones. JUrol 2008; 180: 379-387
52. Umekawa T, Chegini N, Khan SR. Increased expression of monocyte chemoattractant protein-1 (MCP-1) by renal epithelial cells in culture on exposure to calcium oxalate, phosphate and uric acid crystals. Nephrol Dial Transplant 2003; 18: 664-669
53. Umekawa T, Iguchi M, Uemura H et al. Oxalate ions and calcium oxalate crystal-induced up-regulation of osteopontin and monocyte chemoattractant protein-1 in renal fibroblasts. BJU Int 2006; 98: 656-660
54. Pinheiro HS, Camara NO, Osaki KS et al. Early presence of calcium oxalate deposition in kidney graft biopsies is associated with poor long-term graft survival. Am J Transplant 2005; 5: 323-329
55. Saarela T, Lanning P, Koivisto M. Prematurity-associated nephrocalcinosis and kidney function in early childhood. Pediatr Nephrol 1999; 13: 886-890
56. Porter E, McKie A, Beattie TJ et al. Neonatal nephrocalcinosis: long term follow up. Arch Dis Child Fetal Neonatal Ed 2006; 91: F333-F336
57. Abitbol CL, Bauer CR, Montane B et al. Long-term follow-up of extremely low birth weight infants with neonatal renal failure. Pediatr Nephrol 2003; 18: 887-893
58. Kist-Van Holthe JE, van Zwieten PH, Schell-Feith EA et al. Is nephrocalcinosis in preterm neonates harmful for long-term blood pressure and renal function? Pediatrics 2007; 119: 468-475
59. Lieske JC, Swift H, Martin T et al. Renal epithelial cells rapidly bind and internalize calcium oxalate monohydrate crystals. Proc Natl Acad Sci USA 1994; 91: 6987-6991
60. Lieske JC, Norris R, Swift H et al. Adhesion, internalization and metabolism of calcium oxalate monohydrate crystals by renal epithelial cells. Kidney Int 1997; 52: 1291-1301
61. Grover PK, Thurgood LA, Fleming DE et al. Intracrystalline urinary proteins facilitate degradation and dissolution of calcium oxalate crystals in cultured renal cells. Am J Physiol Renal Physiol 2008; 294: F355-F361
62. Kumar V, Farell G, Yu S et al. Cell biology of pathologic renal calcification: contribution of crystal transcytosis, cell-mediated calcification, and nanoparticles. J Investig Med 2006; 54: 412-424
63. De Bruijn WC, Boeve ER, van Run PR et al. Etiology of calcium oxalate nephrolithiasis in rats. I. Can this be a model for human stone formation? Scanning Microsc 1995; 9: 103-114
64. De Bruijn WC, Boeve ER, van Run PR et al. Etiology of experimental calcium oxalate monohydrate nephrolithiasis in rats. Scanning Microsc 1994; 8: 541-549
65. Lieske JC, Spargo BH, Toback FG. Endocytosis of calcium oxalate crystals and proliferation of renal tubular epithelial cells in a patient with type 1 primary hyperoxaluria. JUrol 1992; 148: 1517-1519
66. Steitz SA, Speer MY, Curinga G et al. Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res 2001; 89: 1147-1154
67. Evan AP, Coe FL, Rittling SR et al. Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization. Kidney Int 2005; 68: 145-154
68. Evan AP, Coe FL, Lingeman JE et al. Mechanism of formation of human calcium oxalate renal stones on Randall's plaque. Anat Rec (Hoboken) 2007; 290: 1315-1323
69. Ryall RL, Chauvet MC, Grover PK. Intracrystalline proteins and urolithiasis: a comparison of the protein content and ultrastructure of urinary calcium oxalate monohydrate and dihydrate crystals. BJU Int 2005; 96: 654-663
70. Lyons RR, Fleming DE, Doyle IR et al. Intracrystalline proteins and the hidden ultrastructure of calcium oxalate urinary crystals: implications for kidney stone formation. J Struct Biol 2001; 134: 5-14
71. Kuo RL, Lingeman JE, Evan AP et al. Urine calcium and volume predict coverage of renal papilla by Randall's plaque. Kidney Int 2003; 64: 2150-2154
72. Miller NL, Gillen DL, Williams JC, Jr. et al. A formal test of the hypothesis that idiopathic calcium oxalate stones grow on Randall's plaque. BJU Int 2008; Nov 19. [Epub ahead of print]
73. Randall A. The origin and growth of renal calculi. Ann Surg 1937; 105: 1009-1027
74. Randall A. Papillary pathology as a precursor of primary renal calculus. JUrol 1940; 44: 580-588
75. de Water R, Noordermeer C, Houtsmuller AB et al. Roleof macrophages in nephrolithiasis in rats: an analysis of the renal interstitium. Am J Kidney Dis 2000; 36: 615-625
76. de Water R, Noordermeer C, Van Der Kwast TH et al. Calcium oxalate nephrolithiasis: effect of renal crystal deposition on the cellular composition of the renal interstitium. Am J Kidney Dis 1999; 33: 761-771