Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: A randomized trial

Annals of Internal Medicine

Volumn 157, Issue 6, 2012, Pages 398-406

  Horton, Maureen R ^a   Santopietro, Victoria ^b   Mathew, Leena ^b   Horton, Karen M ^a   Polito, Albert J ^a   Liu, Mark C ^b   Danoff, Sonye K ^a   Lechtzin, Noah ^a  

^a Asthma and Allergy Center ^*  (United States)

^b JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHISTAMINIC AGENT; BENZONATATE; DECONGESTIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; NARCOTIC AGENT; PROTON PUMP INHIBITOR; STEROID; THALIDOMIDE;

AGED; ANOREXIA; ARTICLE; BRADYCARDIA; CHRONIC SINUSITIS; CLINICAL ARTICLE; CONSTIPATION; CONTROLLED STUDY; COUGHING; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG WITHDRAWAL; FEMALE; FIBROSING ALVEOLITIS; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GASTROESOPHAGEAL REFLUX; HUMAN; MALAISE; MALE; OXYGEN THERAPY; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SOMNOLENCE; ST. GEORGE RESPIRATORY QUESTIONNAIRE; VISUAL ANALOG SCALE;

EID: 84868327008     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/0003-4819-157-6-201209180-00003     Document Type: Article

References (39)

1. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, et al; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidencebased guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183:788-824. [PMID: 21471066]
2. Katzenstein AL, Myers JL. Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification. Am J Respir Crit Care Med. 1998;157:1301-15. [PMID: 9563754]
3. King TE Jr, Tooze JA, Schwarz MI, Brown KR, Cherniack RM. Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model. Am J Respir Crit Care Med. 2001;164:1171-81. [PMID: 11673205]
4. Hope-Gill BD, Hilldrup S, Davies C, Newton RP, Harrison NK. A study of the cough reflex in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2003;168:995-1002. [PMID: 12917229]
5. Brown KK. Chronic cough due to chronic interstitial pulmonary diseases: ACCP evidence-based clinical practice guidelines. Chest. 2006;129:180S-185S. [PMID: 16428708]
6. Ryerson CJ, Abbritti M, Ley B, Elicker BM, Jones KD, Collard HR. Cough predicts prognosis in idiopathic pulmonary fibrosis. Respirology. 2011;16:969-75. [PMID: 21615619]
7. Selman M, King TE, Pardo A; American Thoracic Society. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med. 2001;134:136-51. [PMID:11177318]
8. Sime PJ, O'Reilly KM. Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment. Clin Immunol. 2001;99:308-19. [PMID:11358425]
9. King TE Jr. Clinical advances in the diagnosis and therapy of the interstitial lung diseases. Am J Respir Crit Care Med. 2005;172:268-79. [PMID:15879420]
10. Raghu G, Chang J. Idiopathic pulmonary fibrosis: current trends in management. Clin Chest Med. 2004;25:621-36, v. [PMID: 15564012]
11. Madison JM, Irwin RS. Chronic cough in adults with interstitial lung disease. Curr Opin Pulm Med. 2005;11:412-6. [PMID: 16093815]
12. Taussig HB. The thalidomide syndrome. Sci Am. 1962;207:29-35. [PMID:13919872]
13. Eisen T, Boshoff C, Mak I, Sapunar F, Vaughan MM, Pyle L, et al. Continuous low dose thalidomide: a phase II study in advanced melanoma, renal cell, ovarian and breast cancer. Br J Cancer. 2000;82:812-7. [PMID: 10732751]
14. Singhal S, Mehta J, Desikan R, Ayers D, Roberson P, Eddlemon P, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med. 1999;341:1565-71. [PMID: 10564685]
15. Figg WD, Dahut W, Duray P, Hamilton M, Tompkins A, Steinberg SM, et al. A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer. Clin Cancer Res. 2001;7: 1888-93. [PMID: 11448901]
16. Horton MR, Danoff SK, Lechtzin N. Thalidomide inhibits the intractable cough of idiopathic pulmonary fibrosis [Letter]. Thorax. 2008;63:749. [PMID:18663075]
17. Meinert C. Clinical Trials: Design, Conduct, and Analysis. New York: Oxford Univ Pr; 1986.
18. French CT, Irwin RS, Fletcher KE, Adams TM. Evaluation of a cough-specific quality-of-life questionnaire. Chest. 2002;121:1123-31. [PMID:11948042]
19. Jones PW, Quirk FH, Baveystock CM. The St George's Respiratory Questionnaire. Respir Med. 1991;85 Suppl B:25-31. [PMID: 1759018]
20. De Vries J, Seebregts A, Drent M. Assessing health status and quality of life in idiopathic pulmonary fibrosis: which measure should be used? Respir Med. 2000;94:273-8. [PMID: 10783939]
21. Nishiyama O, Taniguchi H, Kondoh Y, Kimura T, Ogawa T, Watanabe F, et al. Health-related quality of life in patients with idiopathic pulmonary fibrosis. What is the main contributing factor? Respir Med. 2005;99:408-14. [PMID:15763446]
22. Swigris JJ, Brown KK, Behr J, du Bois RM, King TE, Raghu G, et al. The SF-36 and SGRQ: validity and first look at minimum important differences in IPF. Respir Med. 2010;104:296-304. [PMID: 19815403]
23. Swigris JJ, Kuschner WG, Jacobs SS, Wilson SR, Gould MK. Healthrelated quality of life in patients with idiopathic pulmonary fibrosis: a systematic review. Thorax. 2005;60:588-94. [PMID: 15994268]
24. Senn S. Cross-over Trials in Clinical Research. West Sussex, United Kingdom: J Wiley; 2002.
25. Cundari S, Cavaletti G. Thalidomide chemotherapy-induced peripheral neuropathy: actual status and new perspectives with thalidomide analogues derivatives. Mini Rev Med Chem. 2009;9:760-8. [PMID: 19519501]
26. Fahim A, Dettmar PW, Morice AH, Hart SP. Gastroesophageal reflux and idiopathic pulmonary fibrosis: a prospective study. Medicina (Kaunas). 2011;47: 200-5. [PMID: 21829051]
27. Zisman DA, Schwarz M, Anstrom KJ, Collard HR, Flaherty KR, Hunninghake GW; Idiopathic Pulmonary Fibrosis Clinical Research Network. A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis. N Engl J Med. 2010;363:620-8. [PMID: 20484178]
28. Raghu G, King TE Jr, Behr J, Brown KK, du Bois RM, Leconte I, et al. Quality of life and dyspnoea in patients treated with bosentan for idiopathic pulmonary fibrosis (BUILD-1). Eur Respir J. 2010;35:118-23. [PMID:19679600]
29. Richeldi L, Costabel U, Selman M, Kim DS, Hansell DM, Nicholson AG, et al. Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis. N Engl J Med. 2011;365:1079-87. [PMID: 21992121]
30. Azuma A, Taguchi Y, Ogura T, Ebina M, Taniguchi H, Kondoh Y, et al; Pirfenidone Clinical Study Group in Japan. Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment. Respir Res. 2011;12:143. [PMID:22035508]
31. Lutherer LO, Nugent KM, Schoettle BW, Cummins MJ, Raj R, Birring SS, et al. Low-dose oral interferon possibly retards the progression of idiopathic pulmonary fibrosis and alleviates associated cough in some patients [Letter]. Thorax. 2011;66:446-7. [PMID: 20837877]
32. Key AL, Holt K, Hamilton A, Smith JA, Earis JE. Objective cough frequency in idiopathic pulmonary fibrosis. Cough. 2010;6:4. [PMID:20565979]
33. Yorke J, Jones PW, Swigris JJ. Development and validity testing of an IPF-specific version of the St George's Respiratory Questionnaire. Thorax. 2010; 65: 921-6. [PMID: 20861296]
34. Raj AA, Pavord DI, Birring SS. Clinical cough IV: what is the minimal important difference for the Leicester Cough Questionnaire? Handb Exp Pharmacol. 2009: 311-20. [PMID: 18825348]
35. Polley L, Yaman N, Heaney L, Cardwell C, Murtagh E, Ramsey J, et al. Impact of cough across different chronic respiratory diseases: comparison of two cough-specific health-related quality of life questionnaires. Chest. 2008;134:295-302. [PMID: 18071022]
36. Jones PW. St. George's Respiratory Questionnaire: MCID. COPD. 2005;2: 75-9. [PMID: 17136966]
37. Kaur A, Yu SS, Lee AJ, Chiao TB. Thalidomide-induced sinus bradycardia. Ann Pharmacother. 2003;37:1040-3. [PMID: 12841816]
38. King TE Jr, Albera C, Bradford WZ, Costabel U, Hormel P, Lancaster L, et al; INSPIRE Study Group. Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial. Lancet. 2009;374:222-8. [PMID: 19570573]
39. Noble PW, Albera C, Bradford WZ, Costabel U, Glassberg MK, Kardatzke D, et al; CAPACITY Study Group. Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials. Lancet. 2011;377: 1760-9. [PMID: 21571362]