Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 end point

Journal of Allergy and Clinical Immunology

Volumn 132, Issue 4, 2013, Pages

  Hilton, Emma C Y ^a   Baverel, Paul G ^b   Woodcock, Ashley ^a   Van Der Graaf, Piet H ^b,c   Smith, Jaclyn A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Capsaicin; challenge; cough; human; model; nonlinear; reflex; response; sensitivity

Indexed keywords

CAPSAICIN;

ADULT; ARTICLE; ASTHMA; CHRONIC COUGH; CLINICAL ARTICLE; CONTROLLED STUDY; COUGHING; DOSE RESPONSE; FEMALE; HUMAN; INHALATION; MALE; PRIORITY JOURNAL; TACHYPHYLAXIS;

EID: 84884904662     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.04.042     Document Type: Article

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