Gabapentin for refractory chronic cough: A randomised, double-blind, placebo-controlled trial

The Lancet

Volumn 380, Issue 9853, 2012, Pages 1583-1589

  Ryan, Nicole M ^a,b   Birring, Surinder S ^d   Gibson, Peter G ^a,b,c  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b JOHN HUNTER HOSPITAL   (Australia)

^c WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GABAPENTIN; PLACEBO;

ADULT; AMNESIA; ARTICLE; AUSTRALIA; BLURRED VISION; CHRONIC COUGH; COMPUTER PROGRAM; CONFIDENCE INTERVAL; CONFUSION; CONTROLLED STUDY; DEPRESSION; DISORIENTATION; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FATIGUE; FEMALE; HEADACHE; HUMAN; INTENTION TO TREAT ANALYSIS; LEICESTER COUGH QUESTIONNAIRE SCORE; MAJOR CLINICAL STUDY; MALE; NAUSEA; OUTCOME ASSESSMENT; OUTPATIENT DEPARTMENT; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; REFRACTORY CHRONIC COUGH; STATISTICAL SIGNIFICANCE; STOMACH PAIN; XEROSTOMIA;

EID: 84868201681     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(12)60776-4     Document Type: Article

References (30)

1. AC Ford, D Forman, P Maoayyedi, AH Morice Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms Thorax 61 2006 975 979
2. SS Birring, B Prudon, AJ Carr, SJ Singh, MDL Morgan, ID Pavord Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire Thorax 58 2003 339 343
3. RS Irwin Diagnosis and management of cough: ACCP evidence-based clinical practice guidelines Chest 129 suppl 2006 24S
4. RA Haque, OS Usmani, PJ Barnes Chronic idiopathic cough: a discrete clinical entity? Chest 127 2005 1710 1713
5. MR Pratter Unexplained (idiopathic) cough: ACCP evidence-based clinical practice guidelines Chest 129 suppl 2006 220S 221S
6. KF Chung Chronic 'cough hypersensitivity syndrome': a more precise label for chronic cough Pulm Pharmacol Ther 24 2011 267 271
7. A Latremoliere, C Woolf Central sensitization: a generator of pain hypersensitivity by central neural plasticity J Pain 10 2009 895 926
8. AE Vertigan, PG Gibson Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers J Voice 25 2011 596 601
9. S Mintz, JK Lee Gabapentin in the treatment of intractable idiopathic chronic cough: case reports Am J Med 119 2006 e13 e15
10. B Lee, P Woo Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment Ann Otol Rhinol Laryngol 114 2005 253 257
11. JY Hsu, RA Stone, RB Logan-Sinclar, M Worsdell, CM Busst, KF Chung Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder Eur Respir J 7 1994 1246 1253
12. NM Ryan, AE Vertigan, PG Gibson Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement Cough 5 2009 4
13. SS Birring, T Fleming, S Matos, AA Raj, DH Evans, ID Pavord The Leicester Cough Monitor: preliminary validation of an automated cough detection system in chronic cough Eur Respir J 31 2008 1013 1018
14. PV Dicpinigaitis Short- and long-term reproducibility of capsaicin cough challenge testing Pulm Pharmacol Ther 16 2003 61 65
15. European Respiratory Society American Thoracic Society ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 Am J Respir Crit Care Med 171 2005 912 930
16. NM Ryan, PG Gibson Extrathoracic airway hyperresponsiveness as a mechanism of post infectious cough: case report Cough 4 2008 7
17. C Bucca, G Rolla, E Scappaticci, S Baldi, E Caria, A Oliva Histamine hyperresponsiveness of the extrathoracic airway in patients with asthmatic symptoms Allergy 46 1991 147 153
18. CML Nieto, A De Diego, TM Perpina, PE Martinez, TL Compte, GV Macian Cough-inducing capsaicin challenge test in a healhy population Arch Bronconeumol 37 2001 292 296
19. ID Pavord, KF Chung Management of chronic cough Lancet 371 2008 1375 1384
20. AA Raj, DI Pavord, SS Birring Clinical cough IV: what is the minimal important difference for the Leicester Cough Questionnaire? Handb Exp Pharmacol 187 2009 311 320
21. P Kimos, C Biggs, J Mah et al. Analgesic action of gabapentin on chronic pain in the masticatory muscles: a randomized controlled trial Pain 127 2007 151 160
22. JN Davies Autonomous breathing Arc Neurol 30 1974 480 484
23. AH Morice, MS Menon, SA Mulrennan et al. Opiate therapy in chronic cough Am J Respir Crit Care Med 175 2007 312 315
24. SS Birring, CE Brightling, FA Symon, SG Barlow, AJ Wardlaw, ID Pavord Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis Thorax 58 2003 1066 1070
25. A Vertigan, D Theodoros, P Gibson, A Winkworth Voice and upper airway symptoms in people with chronic cough and paradoxical vocal fold movement J Voice 21 2007 361 383
26. N Patterson, I Mainie, G Rafferty et al. Nonacid reflux episodes reaching the pharynx are important factors associated with cough J Clin Gastroenterol 43 2009 414 419
27. JM Reich Chronic idiopathic cough: self-sustaining? Chest 131 2007 636
28. RW Bastian, AM Vaidya, KG Delsupehe Sensory neuropathic cough: a common and treatable cause of chronic cough Otolaryngol Head Neck Surg 135 2006 17 21
29. SM Greene, CB Simpson Evidence for sensory neuropathy and pharmacologic management Otolaryngol Clin North Am 43 2010 67 72
30. KK Lee, A Savani, S Matos, C Woods, ID Pavord, SS Birring 4 h cough frequency monitoring with the Leicester Cough Monitor Thorax 65 2010 A54