Genome-scale methods converge on key mitochondrial genes for the survival of human cardiomyocytes in Hypoxia

Circulation: Cardiovascular Genetics

Volumn 7, Issue 4, 2014, Pages 407-415

  Edwards, Lindsay M ^a   Sigurdsson, Martin I ^b   Robbins, Peter A ^c   Weale, Michael E ^d   Cavalleri, Gianpiero L ^e   Montgomery, Hugh E ^f   Thiele, Ines ^g  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^f ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^g UNIVERSITY OF LUXEMBOURG   (Luxembourg)

Author keywords

Computational biology; Genomics; Mitochondria; Systems biology

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ACONITATE HYDRATASE; ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE; FUMARATE HYDRATASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); TRICARBOXYLIC ACID; HEME; PHOSPHOLIPID; TRANSCRIPTOME;

ARTICLE; BIOLOGY; CELL SURVIVAL; FEASIBILITY STUDY; GENOME; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEME SYNTHESIS; HUMAN; HUMAN CELL; HYPOXIA; MITOCHONDRIAL GENE; PHOSPHOLIPID SYNTHESIS; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STEADY STATE; UREA CYCLE; ANOXIA; BIOLOGICAL MODEL; BIOSYNTHESIS; GENETICS; HUMAN GENOME; METABOLISM; MITOCHONDRION; PROTEOMICS;

ADENOSINE TRIPHOSPHATE; ANOXIA; GENOME, HUMAN; HEME; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MITOCHONDRIA; MODELS, BIOLOGICAL; MYOCYTES, CARDIAC; PHOSPHOLIPIDS; POLYMORPHISM, SINGLE NUCLEOTIDE; PRINCIPAL COMPONENT ANALYSIS; PROTEOMICS; TRANSCRIPTOME;

EID: 84925944098     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.113.000269     Document Type: Article

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