The effects of secretion factors from umbilical cord derived mesenchymal stem cells on osteogenic differentiation of mesenchymal stem cells

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Wang, Kui Xing ^a   Xu, Liang Liang ^a,b,c   Rui, Yun Feng ^d   Huang, Shuo ^b,c   Lin, Si En ^b,c   Xiong, Jiang Hui ^a,e   Li, Ying Hui ^a,e   Lee, Wayne Yuk Wai ^a,b,c   Li, Gang ^a,b,c,d  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c Prince of Wales Hospital   (Hong Kong)

^d AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

^e State Key Laboratory of Space Medical Fundamentation and Application Astronaut Research and Training Center of China (ACC)   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALP GENE; ANIMAL CELL; ARTICLE; BMP2 GENE; BONE DEFECT; BONE DEVELOPMENT; BONE REGENERATION; BONE REMODELING; CALVARIA; CELL DIFFERENTIATION; CELL PROLIFERATION; COL1A GENE; CONTROLLED STUDY; GENE; GENE EXPRESSION; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OCN GENE; OSSIFICATION; OSTEOBLAST; OSTERIX GENE; RUNX2 GENE; UMBILICAL CORD; UPREGULATION; ANIMAL; AUTOCRINE EFFECT; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECTS; HUMAN; MALE; MESENCHYMAL STROMA CELL; METABOLISM; NUDE MOUSE; PHENOTYPE; RAT; SECRETION (PROCESS);

MUS MUSCULUS; RATTUS;

BIOLOGICAL MARKER; MEMBRANE ANTIGEN;

ANIMALS; ANTIGENS, SURFACE; AUTOCRINE COMMUNICATION; BIOMARKERS; BONE REGENERATION; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; HUMANS; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, NUDE; OSTEOGENESIS; PHENOTYPE; RATS; UMBILICAL CORD;

EID: 84925847497     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120593     Document Type: Article

References (43)

1. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284: 143-147. PMID: 10102814
2. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002; 418: 41-49. PMID: 12077603
3. Bruder SP, Fink DJ, Caplan AI. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem. 1994; 56: 283-294. PMID: 7876320
4. Krampera M, Pizzolo G, Aprili G, Franchini M. Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair. Bone. 2006; 39: 678-683. PMID: 16765663
5. Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, et al. Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells. 2004; 22: 1330-1337. PMID: 15579650
6. Hendijani F, Sadeghi-Aliabadi H, Haghjooy Javanmard S. Comparison of human mesenchymal stem cells isolated by explant culture method from entire umbilical cord and Wharton's jelly matrix. Cell Tissue Bank. 2014;
7. Carlin R, Davis D, Weiss M, Schultz B, Troyer D. Expression of early transcription factors Oct-4, Sox-2 and Nanog by porcine umbilical cord (PUC) matrix cells. Reprod Biol Endocrinol. 2006; 4: 8. PMID: 16460563
8. Thein-Han W, Xu HH. Collagen-calcium phosphate cement scaffolds seeded with umbilical cord stem cells for bone tissue engineering. Tissue Eng Part A. 2011; 17: 2943-2954. doi: 10.1089/ten.tea.2010.\0674 PMID: 21851269
9. Wang L, Zhao L, Detamore MS. Human umbilical cord mesenchymal stromal cells in a sandwich approach for osteochondral tissue engineering. J Tissue Eng Regen Med. 2011; 5: 712-721. doi: 10. 1002/term.370 PMID: 21953869
10. Can A, Karahuseyinoglu S. Concise review: human umbilical cord stroma with regard to the source of fetus-derived stem cells. Stem Cells. 2007; 25: 2886-2895. PMID: 17690177
11. Baksh D, Yao R, Tuan RS. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells. 2007; 25: 1384-1392. PMID: 17332507
12. Fong CY, Chak LL, Biswas A, Tan JH, Gauthaman K, Chan WK, et al. Human Wharton's jelly stem cells have unique transcriptome profiles compared to human embryonic stem cells and other mesenchymal stem cells. Stem Cell Rev. 2011; 7: 1-16. doi: 10.1007/s12015-010-9166-x PMID: 20602182
13. Wang L, Singh M, Bonewald LF, Detamore MS. Signalling strategies for osteogenic differentiation of human umbilical cord mesenchymal stromal cells for 3D bone tissue engineering. J Tissue Eng Regen Med. 2009; 3: 398-404. doi: 10.1002/term.176 PMID: 19434662
14. Hou T, Xu J, Wu X, Xie Z, Luo F, Zhang Z, et al. Umbilical cord Wharton's Jelly: a new potential cell source of mesenchymal stromal cells for bone tissue engineering. Tissue Eng Part A. 2009; 15: 2325-2334. doi: 10.1089/ten.tea.2008.0402 PMID: 19231937
15. Wang L, Dormer NH, Bonewald LF, Detamore MS. Osteogenic differentiation of human umbilical cord mesenchymal stromal cells in polyglycolic acid scaffolds. Tissue Eng Part A. 2010; 16: 1937-1948. doi: 10.1089/ten.TEA.2009.0706 PMID: 20070186
16. Zhao L, Weir MD, Xu HH. Human umbilical cord stem cell encapsulation in calcium phosphate scaffolds for bone engineering. Biomaterials. 2010; 31: 3848-3857. doi: 10.1016/j.biomaterials.2010.01.093 PMID: 20149437
17. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9: 654-659. PMID: 17486113
18. Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009; 9: 581-593. doi: 10.1038/nri2567 PMID: 19498381
19. Lai RC, Chen TS, Lim SK. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. Regen Med. 2011; 6: 481-492. doi: 10.2217/rme.11.35 PMID: 21749206
20. Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006; 98: 1076-1084. PMID: 16619257
21. Gnecchi M, He H, Liang OD, Melo LG, Morello F, Mu H, et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med. 2005; 11: 367-368. PMID: 15812508
22. Kinnaird T, Stabile E, Burnett MS, Shou M, Lee CW, Barr S, et al. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation. 2004; 109: 1543-1549. PMID: 15023891
23. Byeon YE, Ryu HH, Park SS, Koyama Y, Kikuchi M, Kim WH, et al. Paracrine effect of canine allogenic umbilical cord blood-derived mesenchymal stromal cells mixed with beta-tricalcium phosphate on bone regeneration in ectopic implantations. Cytotherapy. 2010; 12: 626-636. doi: 10.3109/14653249.2010. 481665 PMID: 20438297
24. Patel AN, Vargas V, Revello P, Bull DA. Mesenchymal stem cell population isolated from the subepithelial layer of umbilical cord tissue. Cell Transplant. 2013; 22: 513-519. doi: 10.3727/096368912X655064 PMID: 23057960
25. Majore I, Moretti P, Stahl F, Hass R, Kasper C. Growth and differentiation properties of mesenchymal stromal cell populations derived from whole human umbilical cord. Stem Cell Rev. 2011; 7: 17-31. doi: 10.1007/s12015-010-9165-y PMID: 20596801
26. Hsieh JY, Wang HW, Chang SJ, Liao KH, Lee IH, Lin WS, et al. Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and angiogenesis. PLoS ONE. 2013; 8: e72604. doi: 10.1371/journal.pone.0072604 PMID: 23991127
27. Ando Y, Matsubara K, Ishikawa J, Fujio M, Shohara R, Hibi H, et al. Stem cell-conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms. Bone. 2014; 61: 82-90. doi: 10.1016/j.bone.2013.12.029 PMID: 24389414
28. Sze SK, de Kleijn DP, Lai RC, Khia Way Tan E, Zhao H, Yeo KS, et al. Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007; 6: 1680-1689. PMID: 17565974
29. Timmers L, Lim SK, Hoefer IE, Arslan F, Lai RC, van Oorschot AA, et al. Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. Stem Cell Res. 2011; 6: 206-214. doi: 10.1016/j.scr.2011.01.001 PMID: 21419744
30. Liu Y, Wang L, Kikuiri T, Akiyama K, Chen C, Xu X, et al. Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-gamma and TNF-alpha. Nat Med. 2011; 17: 1594-1601. doi: 10.1038/nm.2542 PMID: 22101767
31. Amable PR, Teixeira MV, Carias RB, Granjeiro JM, Borojevic R. Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton's jelly. Stem Cell Res Ther. 2014; 5: 53. doi: 10.1186/scrt442 PMID: 24739658
32. Baek WY, Lee MA, Jung JW, Kim SY, Akiyama H, de Crombrugghe B, et al. Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix. Journal of Bone and Mineral Research. 2009; 24: 1055-1065. doi: 10.1359/jbmr.081248 PMID: 19113927
33. Liu DD, Zhang JC, Zhang Q, Wang SX, Yang MS. TGF-beta/BMP signaling pathway is involved in ceri-um-promoted osteogenic differentiation of mesenchymal stem cells. J Cell Biochem. 2013; 114: 1105-1114. doi: 10.1002/jcb.24451 PMID: 23150386
34. Komori T. Requisite roles of Runx2 and Cbfb in skeletal development. J Bone Miner Metab. 2003; 21: 193-197. PMID: 12811622
35. Chen D, Li Y, Zhou Z, Xing Y, Zhong Y, Zou X, et al. Synergistic inhibition of Wnt pathway by HIF-1alpha and osteoblast-specific transcription factor osterix (Osx) in osteoblasts. PLoS ONE. 2012; 7: e52948. doi: 10.1371/journal.pone.0052948 PMID: 23300831
36. Ducy P, Schinke T, Karsenty G. The osteoblast: a sophisticated fibroblast under central surveillance. Science. 2000; 289: 1501-1504. PMID: 10968779
37. Staines KA, Pollard AS, McGonnell IM, Farquharson C, Pitsillides AA. Cartilage to bone transitions in health and disease. J Endocrinol. 2013; 219: R1-R12. doi: 10.1530/JOE-13-0276 PMID: 23959079
38. Xu L, Song C, Ni M, Meng F, Xie H, Li G. Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXRalpha-induced betacatenin degradation. Int J Biochem Cell Biol. 2012; 44: 612-619. doi: 10.1016/j.biocel.2011.12.018 PMID: 22230368
39. Spicer PP, Kretlow JD, Young S, Jansen JA, Kasper FK, Mikos AG. Evaluation of bone regeneration using the rat critical size calvarial defect. Nat Protoc. 2012; 7: 1918-1929. doi: 10.1038/nprot.2012.113 PMID: 23018195
40. Cameron JA, Milner DJ, Lee JS, Cheng J, Fang NX, Jasiuk IM. Employing the biology of successful fracture repair to heal critical size bone defects. Curr Top Microbiol Immunol. 2013; 367: 113-132. doi: 10.1007/82-2012-291 PMID: 23239235
41. Bian L, Hou C, Tous E, Rai R, Mauck RL, Burdick JA. The influence of hyaluronic acid hydrogel crosslinking density and macromolecular diffusivity on human MSC chondrogenesis and hypertrophy. Biomaterials. 2013; 34: 413-421. doi: 10.1016/j.biomaterials.2012.09.052 PMID: 23084553
42. Jochmann K, Bachvarova V, Vortkamp A. Reprint of: Heparan sulfate as a regulator of endochondral ossification and osteochondroma development. Matrix Biol. 2014; 35C: 239-247.
43. Khan SN, Lane JM. The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applications. Expert Opin Biol Ther. 2004; 4: 741-748. PMID: 15155165