TGF-β/BMP signaling pathway is involved in cerium-promoted osteogenic differentiation of mesenchymal stem cells

Journal of Cellular Biochemistry

Volumn 114, Issue 5, 2013, Pages 1105-1114

  Liu, Dan Dan ^a   Zhang, Jin Chao ^a   Zhang, Qun ^a   Wang, Shu Xiang ^a   Yang, Meng Su ^b  

^a HEBEI UNIVERSITY   (China)

^b CITY UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

adipogenic differentiation; cerium; mesenchymal stem cells; osteogenic differentiation; signaling pathway

Indexed keywords

ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR; CERIUM; COLLAGEN TYPE 1; OSTEOCALCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA;

ADIPOGENESIS; ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL VIABILITY; DOWN REGULATION; FEMALE; GENE EXPRESSION; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ADIPOGENESIS; ANIMALS; BLOTTING, WESTERN; BONE MATRIX; BONE MORPHOGENETIC PROTEINS; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL SURVIVAL; CERIUM; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MESENCHYMAL STROMAL CELLS; MICE; OSTEOGENESIS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84875148614     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24451     Document Type: Article

References (48)

1. Ailhaud G, Grimaldi P, Negrel R,. 1992. Cellular and molecular aspects of adipose tissue development. Annu Rev Nutr 12: 207-233.
2. Benayahu D, Zipori D, Wientroub S,. 1993. Marrow adipocytes regulate growth and differentiation of osteoblasts. Biochem Biophys Res Commun 197: 1245-1252.
3. Berthon G,. 2002. Aluminum speciation in relation to aluminum bioavailability, metabolism and toxicity. Coord Chem Rev 228: 319-341.
4. Byeong SY, Robert P, Dmitri AO, Isaac Y, Yuji M, Richard RB, Karen ML,. 2006. BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development 133: 4667-4678.
5. + perivascular cells and fibroblasts. Exp Hematol 36: 642-654.
6. Ducy P, Schinke T, Karsenty G,. 2000. The osteoblast: A sophisticated fibroblast under central surveillance. Science 289: 1501-1504.
7. Erlebacher A, Price KA, Glimcher LH,. 2004. Maintenance of mouse trophoblast stem cell proliferation by TGF-beta/activin. Dev Biol 275: 158-169.
8. Evan DR, Ormond AM,. 2006. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7: 885-896.
9. Francis-West PH, Abdelfattah A, Chen P, Allen C, Parish J, Ladher R, Allen S, MacPherson S, Luyten FP, Archer CW,. 1999. Mechanisms of GDF-5 action during skeletal development. Development 126: 1305-1315.
10. Fricker SP,. 2006. The therapeutic application of lanthanides. Chem Soc Rev 35: 524-533.
11. l-[pyridine-2-ylethylidene]acetohydrazide. Der Pharma Chemica 3: 292-304.
12. Komori T,. 2003. Requisite roles of Runx2 and Cbfb in skeletal development. J Bone Miner Metab 21: 193-197.
13. Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL,. 2002. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology 143: 2376-2384.
14. Lee MH, Kim YJ, Kim HJ, Park HD, Kang AR, Kyung HM, Sung JH, Wozney JM, Kim HJ, Ryoo HM,. 2003. BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-β1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 differentiation. J Biol Chem 278: 34387-34394.
15. Lee SJ, Kang SW, Do HJ, Han I, Shin DA, Kim JH, Lee SH,. 2010. Enhancement of bone regeneration by gene delivery of BMP2/Runx2 bicistronic veBTor into adipose-derived stromal cells. Biomaterials 31: 5652-5659.
16. Li BJ,. 2008. Bone morphogenetic protein-smad pathway as drug targets for osteoporosis and cancer therapy. Endocr Metab Immune Disord Drug Targets 8: 208-219.
17. Li JX, Liu JC, Wang K, Yang XG,. 2010. Gadolinium-containing bioparticles as an active entity to promote cell cycle progression in mouse embryo fibroblast NIH3T3 cells. J Biol Inorg Chem 15: 547-557.
18. Limbach LK, Bereiter R, Muller E, Krebs R, Galli R, Stark WJ,. 2008. Removal of oxide nanoparticles in a model wastewater treatment plant: Influence of agglomeration and surfactants on clearing efficiency. Environ Sci Technol 42: 5828-5833.
19. 3+ on osteoblastic differentiation of rat bone marrow stromal cells. Chin Sci Bull 51: 31-37.
20. Liu DD, Yi CQ, Zhang DW, Zhang JC, Yang MS,. 2010. Inhibition of proliferation and differentiation of mesenchymal stem cells by carboxylated carbon nanotubes. ACS Nano 4: 2185-2195.
21. Luo J, Tang M, Huang JY, He BC, Gao JL, Chen L, Guo WZ, Zhang WL, Luo Q, Shi Q, Zhang Q, Yang B, Luo XJ, Jian W, Su YX, Shen JK, Kim SH, Huang EY, Gao YH, Zhou JZ, Yang K, Luu HH, Pan XC, Haydon RC, Deng ZL, He TC,. 2010. TGFβ/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells. J Biol Chem 285: 29588-29598.
22. Mu QX, Du GQ, Chen TS, Zhang B, Yan B,. 2009. Suppression of human bone mophorgenetic protein (BMP) signaling by carboxylated single-walled carbon nanotubes. ACS Nano 3: 1139-1144.
23. Nuttall ME, Gimble JM,. 2000. Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis? Bone 27: 177-184.
24. Owen M, Friedenstein AJ,. 1988. Stromal stem cells: Marrow-derived osteogenic precursors. Ciba Found Symp 136: 42-60.
25. Park B, Donaldson K, Duffin R, Tran L, Kelly F, Mudway I, Morin JP, Guest R, Jenkinson P, Samaras Z, Giannouli M, Kouridis H, Martin P,. 2008a. Hazard and risk assessment of a nanoparticulate cerium oxide-based diesel fuel additive-A case study. Inhal Toxicol 20: 547-566.
26. Park EJ, Choi J, Park YK, Park K,. 2008b. Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells. Toxicology 245: 90-100.
27. Preeta R, Nair RR,. 1999. Stimulation of cardiac fibroblast proliferation by cerium: A superoxide anion-mediated response. J Mol Cell Cardiol 31: 1573-1580.
28. Prockop DJ,. 1997. Marrow stromal cells as stem cells for non-hematopoietic tissues. Science 276: 71-74.
29. Robinson JM, Karnovsky MJ,. 1983. Ultrastructural localization of several phosphatases with cerium. J Histochem Cytochem 31: 1191-1208.
30. Rodrigues M, Griffith LG, Wells A,. 2010. Growth factor regulation of proliferation and survival of multipotential stromal cells. Stem Cell Ther 1: 32-37.
31. Russell KC, Phinney DG, Lacey MR, Barrilleaux BL, Meyertholen KE, O'Connor KC,. 2010. In vitro high-capacity assay to quantify the clonal heterogeniety in tri-lineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage committment. Stem Cells 28: 788-798.
32. Rzigalinski BA,. 2005. Nanoparticles and cell longevity. Technol Cancer Res Treat 4: 651-659.
33. Sekiya I, Larson BL, Smith JR, Pochampally R, Cui JG, Prockop DJ,. 2002. Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progentitors and evaluate their quality. Stem Cells 20: 530-541.
34. Skolnick J, Fetrow JS, Kolinski A,. 2000. Structural genomics and its importance for gene function analysis. Nat Biotechnol 18: 283-287.
35. Snjezana M, Sanja M, Veronika K, Nikolina B, Jasminka JR, Fran B, Drago B, Petra S, Lovorka G, Boris L, Slobodan V,. 2004. Expression of bone morphogenetic proteins in stromal cells from human bone marrow long-term culture. J Histochem Cytochem 52: 1159-1167.
36. Sowa H, Kaji H, Canaff L, Hendy GN, Tsukamoto T, Yamaguchi T, Miyazono K, Sugimoto T, Chihara K,. 2003. Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage. J Biol Chem 278: 21058-21069.
37. Tamama K, Sen CK, Wells A,. 2008. Differentiation of bone marrow mesenchymal stem cells into the smooth muscle lineage by blocking ERK/MAPK signaling pathway. Stem Cells Dev 17: 897-908.
38. Tauber SC, Stadelmann C, Spreer A, Brück W, Nau R, Gerber J,. 2005. Increased expression of BDNF and proliferation of dentate granule cells after bacterial meningitis. J Neuropathol Exp Neurol 64: 806-815.
39. Tsai S, Hollenbeck ST, Ryer EJ, Edlin R, Yamanouchi D, Kundi R, Wang CJ, Liu B, Craig KK,. 2009. TGF-β through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation. Am J Physiol Heart Circ Physiol 297: H540-H549.
40. Wang K, Li RC, Cheng Y, Zhu B,. 1999. Lanthanides-The future drugs? Coord Chem Rev 190-192: 297-308.
41. Wang K, Cheng Y, Yang XD, Li RC,. 2003. Cell responses to lanthanides and potential pharmmacological actions of lanthanides. Met Ions Biol Syst 40: 707-751.
42. Wang J, Ding F, Gu Y, Liu J, Gu XS,. 2009. Bone marrow mesenchymal stem cells promote cell proliferation and neurotrophic function of Schwann cells in vitro and in vivo. Brain Res 1262: 7-15.
43. 2 nanocrystals: Seed-mediated synthesis and size control. Mater Res Bull 43: 990-995.
44. Yi CQ, Liu DD, Fong CC, Zhang JC, Yang MS,. 2010. Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells through p38 MAPK pathway. ACS Nano 4: 6439-6448.
45. Zhang DW, Yi CQ, Zhang JC, Chen Y, Yao XS, Yang MS,. 2007. The effects of carbon nanotubes on the proliferation and differentiation of primary osteoblasts. Nanotechnology 18: 475102-475111.
46. Zhang WX, Yang NL, Shi XM,. 2008. Regulation of mesenchymal stem cell osteogenic differentiation by glucocorticoid-induced leucine zipper (GILZ). J Biol Chem 283: 4723-4729.
47. Zhang F, Qiu T, Wu X, Wan C, Shi W, Wang Y, Chen JG, Wan M, Clemens TL, Cao X,. 2009. Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation. J Bone Miner Res 24: 1224-1233.
48. Zhang JC, Liu CL, Li YP, Sun J, Wang P, Di KQ, Zhao YY,. 2010. Effect of cerium ion on the proliferation, differentiation and mineralization function of primary mouse osteoblasts in vitro. J Rare Earth 28: 138-142.