Mitochondria defects are involved in lead-acetate-induced adult hematopoietic stem cell decline

Toxicology Letters

Volumn 235, Issue 1, 2015, Pages 37-44

  Liu, Jun ^a   Jia, Dao Yong ^a   Cai, Shi Zhong ^b   Li, Cheng Peng ^a   Zhang, Meng Si ^a   Zhang, Yan Yan ^a   Yan, Chong Huai ^c   Wang, Ya Ping ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Hematopoietic stem cell; Lead acetate (PbAc); Mitochondria defect; Reactive oxygen species (ROS); Senescence

Indexed keywords

ASCORBIC ACID; CD45 ANTIGEN; LEAD ACETATE; REACTIVE OXYGEN METABOLITE; THY 1 ANTIGEN; ANTIOXIDANT; ORGANOMETALLIC COMPOUND; PTPRC PROTEIN, RAT;

ADULT; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL LINEAGE; COLONY FORMING UNIT; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENVIRONMENTAL EXPOSURE; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; LIPID PEROXIDATION ASSAY; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; RAT; ADULT STEM CELL; ANIMAL; CELL AGING; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; FEMALE; HEMATOPOIESIS; LEAD POISONING; MALE; METABOLISM; MITOCHONDRION; PATHOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ADULT STEM CELLS; ANIMALS; ANTIGENS, CD45; ANTIGENS, THY-1; ANTIOXIDANTS; APOPTOSIS; CELL AGING; CELL LINEAGE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; LEAD POISONING; MALE; MITOCHONDRIA; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; PHENOTYPE; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84925844579     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2015.03.007     Document Type: Article

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