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HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A
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Bartha I, Carlson JM, Brumme CJ, et al. A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control. eLife 2013;2:e01123. This study used viral and host genetic variation to identify regions of genetic conflict between HIV and the infected patient. Studies in which both host and pathogen genome sequences are available can enhance power for discovery and more fully explore the role of genetics in pathogenesis.
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Identification of host proteins required for HIV infection through a functional genomic screen
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Fraser C, Lythgoe K, Leventhal GE, et al. Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective. Science 2014;343:1243727. Understanding how much of the variability in HIV disease progression is because of genetics is of key importance. This perspective outlines the methods for measuring heritability and provides insight into how the host and viral components can be assessed.
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