Virulence and pathogenesis of HIV-1 infection: An evolutionary perspective

Science

Volumn 343, Issue 6177, 2014, Pages

  Fraser, Christophe ^a   Lythgoe, Katrina ^a   Leventhal, Gabriel E ^b   Shirreff, George ^b   Hollingsworth, T Déirdre ^c,d,e   Alizon, Samuel ^f   Bonhoeffer, Sebastian ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF WARWICK   (United Kingdom)

^d UNIVERSITY OF WARWICK   (United Kingdom)

^e LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^f UNIV MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B57 ANTIGEN; VIRULENCE FACTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; DISEASE SEVERITY; FITNESS; GENETIC ANALYSIS; HUMAN IMMUNODEFICIENCY VIRUS; PATHOGENICITY; SELECTION; VIRULENCE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ASYMPTOMATIC INFECTION; CD4+ T LYMPHOCYTE; DISEASE SEVERITY; GENOTYPE; HERITABILITY; HOST SELECTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; MEN WHO HAVE SEX WITH MEN; MUTATION RATE; NATURAL SELECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SET LIKE VIRAL LOAD; T LYMPHOCYTE ACTIVATION; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS LOAD; VIRUS MUTATION; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TRANSMISSION; VIRUS VIRULENCE; ADAPTATION; BIOLOGICAL MODEL; DISEASE TRANSMISSION; GENETIC SELECTION; GENETICS; HOST PATHOGEN INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOLECULAR EVOLUTION; PATHOGENICITY; PHYSIOLOGY; VIROLOGY; VIRULENCE;

ADAPTATION, PHYSIOLOGICAL; EVOLUTION, MOLECULAR; HIV INFECTIONS; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; MODELS, BIOLOGICAL; SELECTION, GENETIC; VIRAL LOAD; VIRULENCE; VIRULENCE FACTORS; VIRUS REPLICATION;

EID: 84896918882     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1243727     Document Type: Review

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