Variants in host viral replication cycle genes are associated with heterosexual HIV-1 acquisition in Africans

Journal of Acquired Immune Deficiency Syndromes

Volumn 66, Issue 2, 2014, Pages 127-134

  Bigham, Abigail W ^a   Mackelprang, Romel D ^b   Celum, Connie ^b   Bruyn, Guy De ^c   Beima Sofie, Kristin ^b   John Stewart, Grace ^b   Ronald, Allan ^d   Mugo, Nelly R ^b,e   Buckingham, Kati ^f   Bamshad, Michael J ^b,f   Mullins, James I ^b,d   McElrath, M J ^d,g   Lingappa, Jairam R ^b,f  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^d UNIVERSITY OF MANITOBA   (Canada)

^e UNIVERSITY OF NAIROBI   (Kenya)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^g USA   (United States)

Author keywords

Africa; cell cycle genes; genotype phenotype association; HIV; HIV genetics

Indexed keywords

VIRUS RNA;

ADULT; CASE CONTROL STUDY; CCR5 GENE; CD4+ T LYMPHOCYTE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; FUT2 GENE; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MALE; MBL2 GENE; PPIA GENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMARCB1 GENE; VIRUS REPLICATION; VIRUS TRANSMISSION;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; DISEASE PROGRESSION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HIV INFECTIONS; HIV-1; HUMANS; LOGISTIC MODELS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPORTIONAL HAZARDS MODELS; RNA, VIRAL; VIRAL LOAD; VIRUS REPLICATION; YOUNG ADULT;

EID: 84901481450     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000000113     Document Type: Conference Paper

References (39)

1. Smith MW, Dean M, Carrington M, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science. 1997;277:959-965.
2. UN Joint Program on HIV/AIDS. Global Report: UNAIDS Report on the Global AIDS Epidemic: 2010. Available at: http://www.refworld.org/docid/4cfca9c62.html. Accessed August 1, 2013.
3. Mackelprang RD, Baeten JM, Donnell D, et al. Quantifying ongoing HIV-1 exposure in HIV-1-serodiscordant couples to identify individuals with potential host resistance to HIV-1. J Infect Dis. 2012;206:1299-1308.
4. Lingappa JR, Petrovski S, Kahle E, et al. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. PLoS One. 2011;6: e28632.
5. Celum C, Wald A, Lingappa JR, et al. Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N Engl J Med. 2010;362:427-439.
6. Campbell MS, Mullins JI, Hughes JP, et al. Viral linkage in HIV-1 seroconverters and their partners in an HIV-1 prevention clinical trial. PLoS One. 2011;6:e16986.
7. Kahle EM, Campbell M, Lingappa J, et al. HIV-1 subtype C is not associated with higher risk of heterosexual transmission: a multinational study among African HIV-1 serodiscordant couples. Presented at: AIDS 2012; July 22-27, 2012; Washington, DC.
8. Campbell MS, Kahle EM, Celum C, et al. Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters. J Infect Dis. 2013;207:1166-1170.
9. Lingappa JR, Dooher JE, Newman MA, Kiser PK, Klein KC. Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly. J Biol Chem. 2006;281:3773-3784. (Pubitemid 43847801)
10. Zimmerman C, Klein KC, Kiser PK, et al. Identification of a host protein essential for assembly of immature HIV-1 capsids. Nature. 2002;415: 88-92. (Pubitemid 34062455)
11. Jayappa KD, Ao Z, Yao X. The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration. Int J Biochem Mol Biol. 2012;3:70-85.
12. Malim MH. APOBEC proteins and intrinsic resistance to HIV-1 infection. Philos Trans R Soc Lond B Biol Sci. 2009;364:675-687.
13. Franke EK, Yuan HE, Luban J. Specific incorporation of cyclophilin A into HIV-1 virions. Nature. 1994;372:359-362. (Pubitemid 24363437)
14. Berthoux L, Sebastian S, Sokolskaja E, et al. Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells. Proc Natl Acad Sci USA. 2005;102:14849-14853. (Pubitemid 41457144)
15. Blot V, Perugi F, Gay B, et al. Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding. J Cell Sci. 2004;117(pt 11):2357-2367. (Pubitemid 38807502)
16. Strack B, Calistri A, Craig S, et al. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell. 2003;114: 689-699. (Pubitemid 37186765)
17. Bushman FD, Malani N, Fernandes J, et al. Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog. 2009;5: e1000437.
18. Price AL, Patterson NJ, Plenge RM, et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38:904-909. (Pubitemid 44141658)
19. Lingappa JR, Baeten JM, Wald A, et al. Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial. Lancet. 2010;375:824-833.
20. Luban J, Bossolt KL, Franke EK, et al. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell. 1993;73:1067-1078. (Pubitemid 23180482)
21. An P, Wang LH, Hutcheson-Dilks H, et al. Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. PLoS Pathog. 2007;3:e88.
22. Brown P. Integration. In: Coffin JM, Hughes SH, Varmus HE, eds. Retroviruses. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1997:161-203.
23. Yung E, Sorin M, Pal A, et al. Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1. Nat Med. 2001;7: 920-926. (Pubitemid 32756429)
24. Cano J, Kalpana GV. Inhibition of early stages of HIV-1 assembly by INI1/hSNF5 transdominant negative mutant S6. J Virol. 2011;85: 2254-2265.
25. Martin MP, Dean M, Smith MW, et al. Genetic acceleration of AIDS progression by a promoter variant of CCR5. Science. 1998;282: 1907-1911.
26. Fellay J, Ge D, Shianna KV, et al. Common genetic variation and the control of HIV-1 in humans. PLoS Genet. 2009;5:e1000791.
27. Salkowitz JR, Bruse SE, Meyerson H, et al. CCR5 promoter polymorphism determines macrophage CCR5 density and magnitude of HIV-1 propagation in vitro. Clin Immunol. 2003;108:234-240. (Pubitemid 37117369)
28. Malhotra R, Hu L, Song W, et al. Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians. Retrovirology. 2011;8:22.
29. Kindberg E, Hejdeman B, Bratt G, et al. A nonsense mutation (428G→A) in the fucosyltransferase FUT2 gene affects the progression of HIV-1 infection. AIDS. 2006;20:685-689. (Pubitemid 43884295)
30. Worthley DL, Bardy PG, Mullighan CG. Mannose-binding lectin: biology and clinical implications. Intern Med J. 2005;35:548-555. (Pubitemid 41291384)
31. Mombo LE, Lu CY, Ossari S, et al. Mannose-binding lectin alleles in sub-Saharan Africans and relation with susceptibility to infections. Genes Immun. 2003;4:362-367. (Pubitemid 38961144)
32. Garred P, Madsen HO, Balslev U, et al. Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin. Lancet. 1997;349:236-240. (Pubitemid 27050989)
33. da Silva GK, Guimaraes R, Mattevi VS, et al. The role of mannosebinding lectin gene polymorphisms in susceptibility to HIV-1 infection in Southern Brazilian patients. AIDS. 2011;25:411-418.
34. Fellay J, Shianna KV, Ge D, et al. A whole-genome association study of major determinants for host control of HIV-1. Science. 2007;317: 944-947. (Pubitemid 47301321)
35. McLaren PJ, Coulonges C, Ripke S, et al. Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls. PLoS Pathog. 2013;9:e1003515.
36. Hirschhorn JN, Daly MJ. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet. 2005;6:95-108. (Pubitemid 40179532)
37. Conrad DF, Jakobsson M, Coop G, et al. A worldwide survey of haplotype variation and linkage disequilibrium in the human genome. Nat Genet. 2006;38:1251-1260. (Pubitemid 44646287)
38. Teo YY, Small KS, Kwiatkowski DP. Methodological challenges of genome-wide association analysis in Africa. Nat Rev Genet. 2010;11: 149-160.
39. Petrovski S, Fellay J, Shianna KV, et al. Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. AIDS. 2011;25:513-518.