Validated LC-MS/MS method for simultaneous determination of SIM and its acid form in human plasma and cell lysate: Pharmacokinetic application

Journal of Pharmaceutical Analysis

Volumn 2, Issue 6, 2012, Pages 403-411

  Ahmed, Tamer A ^a   Horn, Jamie ^a   Hayslip, John ^b   Leggas, Markos ^a,b  

^a University of Kentucky   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Cell lysate; High dose; Human plasma; LC MS MS; Pharmacokinetic; Simvastatin

Indexed keywords

AMMONIUM ACETATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SIMVASTATIN; SIMVASTATIN ACID; UNCLASSIFIED DRUG;

ARTICLE; CANCER PATIENT; CELL LYSATE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MEGADOSE; DRUG STABILITY; HUMAN; IONIZATION; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PERIPHERAL BLOOD MONONUCLEAR CELL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY;

EID: 84925835413     PISSN: 20951779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpha.2012.07.010     Document Type: Article

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