Determination of simvastatin and its active metabolite in human plasma by column-switching high-performance liquid chromatography with fluorescence detection after derivatization with 1-bromoacetylpyrene

Journal of Chromatography B: Biomedical Applications

Volumn 694, Issue 1, 1997, Pages 211-217

  Ochiai, Hisao ^a   Uchiyama, Naotaka ^a   Imagaki, Kazuhide ^a   Hata, Shunsuke ^a   Kamei, Toshio ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

1 Bromoacetylpyrene; Simvastatin

Indexed keywords

DRUG METABOLITE; REAGENT; SIMVASTATIN;

ANALYTIC METHOD; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; FLUORESCENCE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VOLUNTEER;

ANTICHOLESTEREMIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORESCENT DYES; HUMANS; LOVASTATIN; PYRENES; SENSITIVITY AND SPECIFICITY; SIMVASTATIN; SPECTROMETRY, FLUORESCENCE;

EID: 0030918397     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(97)00091-1     Document Type: Article

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