Simultaneous determination of simvastatin and simvastatin acid in human plasma by LC-MS/MS without polarity switch: Application to a bioequivalence study

Journal of Separation Science

Volumn 31, Issue 2, 2008, Pages 301-313

  Patel, Bhavin N ^a,b   Sharma, Naveen ^b   Sanyal, Mallika ^c   Shrivastav, Pranav S ^a  

^a GUJARAT UNIVERSITY   (India)

^b BA Research India Limited   (India)

^c ST XAVIER S COLLEGE   (India)

Author keywords

Flash freezing; Human plasma; LC MS MS; Simvastatin; Simvastatin acid

Indexed keywords

BIOEQUIVALENCE STUDY; FLASH FREEZING; LIQUID-LIQUID EXTRACTION; SIMVASTATIN ACID; TURBO ION SPRAY INTERFACE;

CHEMICAL ANALYSIS; EXTRACTION; FREEZING; MASS SPECTROMETRY; ORGANIC ACIDS; PLASMA (HUMAN);

LIQUID CHROMATOGRAPHY;

SIMVASTATIN; SIMVASTATIN ACID; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ARTICLE; BIOEQUIVALENCE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION COEFFICIENT; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG DETERMINATION; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; MONITORING; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TABLET FORMULATION; VALIDATION PROCESS;

CHROMATOGRAPHY, LIQUID; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SIMVASTATIN; TANDEM MASS SPECTROMETRY; THERAPEUTIC EQUIVALENCY;

EID: 39549091516     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200700367     Document Type: Article

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