Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion

Journal of Biological Chemistry

Volumn 290, Issue 13, 2015, Pages 8271-8282

  Nolan, Krystal D ^a   Franco, Omar E ^b,c   Hance, Michael W ^a   Hayward, Simon W ^b,c   Isaacs, Jennifer S ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; UROLOGY;

CANCER CELLS; DISEASE PROGRESSION; EXTRACELLULAR; HISTONE METHYLATION; POLYCOMB; PROSTATE TUMOR; TUMORIGENESIS;

TUMORS;

HEAT SHOCK PROTEIN 90; METHYLTRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; POLYCOMB GROUP PROTEIN; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; CADHERIN; CDH1 PROTEIN, HUMAN; EZH2 PROTEIN, HUMAN; POLYCOMB REPRESSIVE COMPLEX 2;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOIKIS; ARTICLE; CANCER CELL; CANCER GROWTH; CELL MOTILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IN VIVO STUDY; MESENCHYME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE SECRETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR CELL; TUMOR INVASION; UPREGULATION; ANIMAL; CANCER TRANSPLANTATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HEK293 CELL LINE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; SCID MOUSE; SECRETION (PROCESS); TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; CADHERINS; CELL LINE, TUMOR; EPIGENESIS, GENETIC; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MICE, SCID; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; POLYCOMB REPRESSIVE COMPLEX 2; POLYCOMB-GROUP PROTEINS; PROSTATIC NEOPLASMS; TUMOR BURDEN;

EID: 84925831809     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.637496     Document Type: Article

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