High fidelity between saliva proteomics and the biologic state of salivary glands defines biomarker signatures for primary Sjögren's syndrome

Arthritis and Rheumatology

Volumn 67, Issue 4, 2015, Pages 1084-1095

  Delaleu, Nicolas ^a   Mydel, Piotr ^a   Kwee, Ivo ^b,c   Brun, Johan G ^a   Jonsson, Malin V ^a   Jonsson, Roland ^a  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

^c DALLE MOLLE INSTITUTE FOR ARTIFICIAL INTELLIGENCE IDSIA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A2; APOLIPOPROTEIN C1; APOLIPOPROTEIN E; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CD40 LIGAND; CLUSTERIN; CONNECTIVE TISSUE GROWTH FACTOR; CXCL9 CHEMOKINE; FIBROBLAST GROWTH FACTOR 4; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 1; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; PREGNANCY ASSOCIATED PLASMA PROTEIN A; PROTEOME; VASCULOTROPIN A;

ADULT; AGED; ARTICLE; ASYMPTOMATIC DISEASE; B LYMPHOCYTE ACTIVATION; CELL DIFFERENTIATION; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE ONTOLOGY; GERMINAL CENTER; GRANULOCYTE; HUMAN; HYPOSALIVATION; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOGLOBULIN PRODUCTION; INNATE IMMUNITY; LIPID TRANSPORT; LIPOPROTEIN BLOOD LEVEL; MACROPHAGE; PRIORITY JOURNAL; PROTEOMICS; RHEUMATOID ARTHRITIS; SALIVARY GLAND; SALIVATION; SIALOADENITIS; SJOEGREN SYNDROME; SYSTEMS BIOLOGY; ARTHRITIS, RHEUMATOID; METABOLISM; MIDDLE AGED; SALIVA; SJOGREN'S SYNDROME; YOUNG ADULT;

ADULT; AGED; ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CLUSTERIN; FEMALE; GERMINAL CENTER; HUMANS; INTERLEUKIN-4; INTERLEUKIN-5; MIDDLE AGED; PROTEOMICS; SALIVA; SALIVARY GLANDS; SJOGREN'S SYNDROME; YOUNG ADULT;

EID: 84925808775     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39015     Document Type: Article

References (46)

1. Maecker HT, Lindstrom TM, Robinson WH, Utz PJ, Hale M, Boyd SD, et al. New tools for classification and monitoring of autoimmune diseases. Nat Rev Rheumatol 2012; 8: 317-28.
2. Henson BS, Wong DT,. Collection, storage, and processing of saliva samples for downstream molecular applications. Methods Mol Biol 2010; 666: 21-30.
3. Jonsson MV, Delaleu N, Marthinussen MC, Jonsson R,. Oral and dental manifestations of Sjögren's syndrome: current approaches to diagnostics and therapy. In:, Fox RI, Fox C, editors. Sjögren's syndrome: current topics of pathogenesis and therapy. 1st ed. New York: Springer; 2011. p. 221-42.
4. Good DM, Thongboonkerd V, Novak J, Bascands JL, Schanstra JP, Coon JJ, et al. Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future. J Proteome Res 2007; 6: 4549-55.
5. Yoshizawa JM, Schafer CA, Schafer JJ, Farrell JJ, Paster BJ, Wong DT,. Salivary biomarkers: toward future clinical and diagnostic utilities. Clin Microbiol Rev 2013; 26: 781-91.
6. Baldini C, Gallo A, Perez P, Mosca M, Alevizos I, Bombardieri S,. Saliva as an ideal milieu for emerging diagnostic approaches in primary Sjögren's syndrome. Clin Exp Rheumatol 2012; 30: 785-90.
7. Hu S, Yu T, Xie Y, Yang Y, Li Y, Zhou X, et al. Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry. Cancer Genomics Proteomics 2007; 4: 55-64.
8. Delaleu N, Madureira AC, Immervoll H, Jonsson R,. Inhibition of experimental Sjögren's syndrome through immunization with Hsp60 and its peptide amino acids 437-460. Arthritis Rheum 2008; 58: 2318-28.
9. Goransson LG, Haldorsen K, Brun JG, Harboe E, Jonsson MV, Skarstein K, et al. The point prevalence of clinically relevant primary Sjögren's syndrome in two Norwegian counties. Scand J Rheumatol 2011; 40: 221-4.
10. Delaleu N, Jonsson MV, Appel S, Jonsson R,. New concepts in the pathogenesis of Sjögren's syndrome. Rheum Dis Clin North Am 2008; 34: 833-45, vii.
11. Delaleu N, Manoussakis MN, Moutsopoulos HM, Jonsson R,. Etiology and pathogenesis of Sjögren's syndrome with special emphasis on the salivary glands. In:, Fox RI, Fox C, editors. Sjögren's syndrome: current topics of pathogenesis and therapy. 1st ed. New York: Springer; 2011. p. 243-68.
12. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al, and the European Study Group on Classification Criteria for Sjögren's Syndrome. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61: 554-8.
13. Jonsson R, Theander E, Sjostrom B, Brokstad K, Henriksson G,. Autoantibodies present before symptom onset in primary Sjögren syndrome. JAMA 2013; 310: 1854-5.
14. Rasmussen A, Ice JA, Li H, Grundahl K, Kelly JA, Radfar L, et al. Comparison of the American-European Consensus Group Sjögren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort. Ann Rheum Dis 2014; 73: 31-8.
15. Salomonsson S, Jonsson MV, Skarstein K, Brokstad KA, Hjelmstrom P, Wahren-Herlenius M, et al. Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome. Arthritis Rheum 2003; 48: 3187-201.
16. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
17. Balboni I, Chan SM, Kattah M, Tenenbaum JD, Butte AJ, Utz PJ,. Multiplexed protein array platforms for analysis of autoimmune diseases. Annu Rev Immunol 2006; 24: 391-418.
18. Welsh BT, Mapes J,. An overview of assay quality systems at Myriad RBM, Inc. QC white paper. January 2013. URL: https://s3.amazonaws.com/myriad-web/myriadrbm.com/docs/MyriadRBM-QC-Whitepaper.pdf.
19. Timm NH,. Applied multivariate analysis. New York: Springer; 2002.
20. Bindea G, Galon J, Mlecnik B,. CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data. Bioinformatics 2013; 29: 661-3.
21. Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T,. Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 2011; 27: 431-2.
22. Kaufman E, Lamster IB,. The diagnostic applications of saliva: a review. Crit Rev Oral Biol Med 2002; 13: 197-212.
23. Lynch EA, Heijens CA, Horst NF, Center DM, Cruikshank WW,. IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5. J Immunol 2003; 171: 4965-8.
24. Bromley SK, Mempel TR, Luster AD,. Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol 2008; 9: 970-80.
25. Vance DE, Vance JE, editors. Biochemistry of lipids, lipoproteins and membranes. 5th ed. Amsterdam: Elsevier; 2008.
26. Libby P, Ridker PM, Hansson GK,. Progress and challenges in translating the biology of atherosclerosis. Nature 2011; 473: 317-25.
27. Shehzad A, Iqbal W, Shehzad O, Lee YS,. Adiponectin: regulation of its production and its role in human diseases. Hormones (Athens) 2012; 11: 8-20.
28. Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, et al. The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res 2008; 7: 1994-2006.
29. Spielmann N, Ilsley D, Gu J, Lea K, Brockman J, Heater S, et al. The human salivary RNA transcriptome revealed by massively parallel sequencing. Clin Chem 2012; 58: 1314-21.
30. Ai J, Smith B, Wong DT,. Saliva Ontology: an ontology-based framework for a Salivaomics Knowledge Base. BMC Bioinformatics 2010; 11: 302.
31. Xiao H, Zhang L, Zhou H, Lee JM, Garon EB, Wong DT,. Proteomic analysis of human saliva from lung cancer patients using two-dimensional difference gel electrophoresis and mass spectrometry. Mol Cell Proteomics 2012; 11: M111.012112.
32. Zhang L, Farrell JJ, Zhou H, Elashoff D, Akin D, Park NH, et al. Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer. Gastroenterology 2010; 138: 949-57.e7.
33. Mallick P, Kuster B,. Proteomics: a pragmatic perspective. Nat Biotechnol 2010; 28: 695-709.
34. Altelaar AF, Munoz J, Heck AJ,. Next-generation proteomics: towards an integrative view of proteome dynamics. Nat Rev Genet 2013; 14: 35-48.
35. Baldini C, Giusti L, Ciregia F, Da Valle Y, Giacomelli C, Donadio E, et al. Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes. Arthritis Res Ther 2011; 13: R194.
36. Ambatipudi KS, Swatkoski S, Moresco JJ, Tu PG, Coca A, Anolik JH, et al. Quantitative proteomics of parotid saliva in primary Sjögren's syndrome. Proteomics 2012; 12: 3113-20.
37. Delaleu N, Immervoll H, Cornelius J, Jonsson R,. Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations. Arthritis Res Ther 2008; 10: R22.
38. Wells G, Becker JC, Teng J, Dougados M, Schiff M, Smolen J, et al. Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann Rheum Dis 2009; 68: 954-60.
39. Gene Ontology Consortium, Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, et al. Gene ontology: tool for the unification of biology. Nat Genet 2000; 25: 25-9.
40. Groom J, Kalled SL, Cutler AH, Olson C, Woodcock SA, Schneider P, et al. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J Clin Invest 2002; 109: 59-68.
41. Vincent FB, Saulep-Easton D, Figgett WA, Fairfax KA, Mackay F,. The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity. Cytokine Growth Factor Rev 2013; 24: 203-15.
42. Koltai T,. Clusterin: a key player in cancer chemoresistance and its inhibition. OncoTargets Ther 2014; 7: 447-56.
43. Boldt HB, Conover CA,. Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs. Growth Horm IGF Research 2007; 17: 10-8.
44. Szodoray P, Alex P, Jonsson MV, Knowlton N, Dozmorov I, Nakken B, et al. Distinct profiles of Sjögren's syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF. Clin Immunol 2005; 117: 168-76.
45. Theander E, Vasaitis L, Baecklund E, Nordmark G, Warfvinge G, Liedholm R, et al. Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjögren's syndrome. Ann Rheum Dis 2011; 70: 1363-8.
46. Delaleu N, Nguyen CQ, Peck AB, Jonsson R,. Sjögren's syndrome: studying the disease in mice. Arthritis Res Ther 2011; 13: 217.