Human umbilical mesenchymal stem cells enhance the expression of neurotrophic factors and protect ataxic mice

Brain Research

Volumn 1402, Issue , 2011, Pages 122-131

  Zhang, Mei Juan ^a,b   Sun, Jia Jia ^a,b   Qian, Lai ^a,b   Liu, Zhuo ^a,b   Zhang, Zhuo ^a,b   Cao, Wangsen ^a,b   Li, Wei ^c   Xu, Yun ^a,b  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c Jiangsu Provincial Stem Cell Engineering Research Center   (China)

Author keywords

Ara C; Cerebellar ataxia; HU MSCs; Neuroprotection; Neurotrophic factors

Indexed keywords

CYTARABINE; NEUROTROPHIC FACTOR; SOMATOMEDIN C; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; BEHAVIOR; BRAIN SIZE; BRAIN WEIGHT; CEREBELLAR ATAXIA; CEREBELLUM; CEREBELLUM ATROPHY; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NICK END LABELING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICUS;

ANIMALS; CELL LINE; CEREBELLAR ATAXIA; CORD BLOOD STEM CELL TRANSPLANTATION; FETAL BLOOD; GENE EXPRESSION REGULATION; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED ICR; NERVE GROWTH FACTORS; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA; ARA; MUS;

EID: 79960241187     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.05.055     Document Type: Article

References (39)

1. X. Bao, J. Wei, M. Feng, S. Lu, G. Li, W. Dou, W. Ma, S. Ma, Y. An, C. Qin, R.C. Zhao, and R. Wang Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats Brain Res. 1367 2011 103 113
2. C.V. Borlongan, M. Hadman, C.D. Sanberg, and P.R. Sanberg Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke Stroke 35 2004 2385 2389 (Pubitemid 39311268)
3. J. Cendelin, I. Korelusova, and F. Vozeh The effect of cerebellar transplantation and enforced physical activity on motor skills and spatial learning in adult Lurcher mutant mice Cerebellum 8 2009 35 45
4. H. Das, J.C. George, M. Joseph, M. Das, N. Abdulhameed, A. Blitz, M. Khan, R. Sakthivel, H.Q. Mao, B.D. Hoit, P. Kuppusamy, and V.J. Pompili Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model PLoS One 4 2009 e7325
5. M. Dominici, K. Le Blanc, I. Mueller, I. Slaper-Cortenbach, F. Marini, D. Krause, R. Deans, A. Keating, D. Prockop, and E. Horwitz Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement Cytotherapy 8 2006 315 317 (Pubitemid 44269669)
6. A.M. Fernandez, A.G. Gonzalez de la Vega, B. Planas, and I. Torres-Aleman Neuroprotective actions of peripherally administered insulin-like growth factor I in the injured olivo-cerebellar pathway Eur. J. Neurosci. 11 1999 2019 2030 (Pubitemid 29240567)
7. N. Horie, M.P. Pereira, K. Niizuma, G. Sun, H. Keren-Gill, A. Encarnacion, M. Shamloo, S.A. Hamilton, K. Jiang, S. Huhn, T.D. Palmer, T.M. Bliss, and G.K. Steinberg Transplanted Stem Cell-Secreted VEGF Effects Post-Stroke Recovery, Inflammation, and Vascular Repair 2011 Stem Cells (Electronic publication ahead of print)
8. A. Joseph D'Ercole, and P. Ye Expanding the mind: insulin-like growth factor I and brain development Endocrinology 149 2008 5958 5962
9. N. Joyce, G. Annett, L. Wirthlin, S. Olson, G. Bauer, and J.A. Nolta Mesenchymal stem cells for the treatment of neurodegenerative disease Regen. Med. 5 2010 933 946
10. W.F. Kaemmerer, and W.C. Low Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1 Exp. Neurol. 158 1999 301 311 (Pubitemid 29382822)
11. S.H. Koh, K.S. Kim, M.R. Choi, K.H. Jung, K.S. Park, Y.G. Chai, W. Roh, S.J. Hwang, H.J. Ko, Y.M. Huh, H.T. Kim, and S.H. Kim Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats Brain Res. 1229 2008 233 248
12. J. Liang, H. Zhang, B. Hua, H. Wang, J. Wang, Z. Han, and L. Sun Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis Mult. Scler. 15 2009 644 646
13. L. Liu, J.X. Cao, B. Sun, H.L. Li, Y. Xia, Z. Wu, C.L. Tang, and J. Hu Mesenchymal stem cells inhibition of chronic ethanol-induced oxidative damage via upregulation of phosphatidylinositol-3-kinase/Akt and modulation of extracellular signal-regulated kinase 1/2 activation in PC12 cells and neurons Neuroscience 167 2010 1115 1124
14. K.D. McElreavey, A.I. Irvine, K.T. Ennis, and W.H. McLean Isolation, culture and characterisation of fibroblast-like cells derived from the Wharton's jelly portion of human umbilical cord Biochem. Soc. Trans. 19 1991 29S
15. H. Meng, Z. Zhang, R. Zhang, X. Liu, L. Wang, A.M. Robin, and M. Chopp Biphasic effects of exogenous VEGF on VEGF expression of adult neural progenitors Neurosci. Lett. 393 2006 97 101 (Pubitemid 41821087)
16. O. Muramoto, K. Ando, and I. Kanazawa Central noradrenaline metabolism in cerebellar ataxic mice Brain Res. 237 1982 387 395 (Pubitemid 12101946)
17. T. Nomura, O. Honmou, K. Harada, K. Houkin, H. Hamada, and J.D. Kocsis I.V. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat Neuroscience 136 2005 161 169 (Pubitemid 41483844)
18. M. Ogawa Pharmacological treatments of cerebellar ataxia Cerebellum 3 2004 107 111 (Pubitemid 38797071)
19. K. Ohsugi, K. Adachi, and K. Ando Serotonin metabolism in the CNS in cerebellar ataxic mice Experientia 42 1986 1245 1247 (Pubitemid 17193062)
20. C. Ruiz de Almodovar, D. Lambrechts, M. Mazzone, and P. Carmeliet Role and therapeutic potential of VEGF in the nervous system Physiol. Rev. 89 2009 607 648
21. A. Scuteri, M. Ravasi, S. Pasini, M. Bossi, and G. Tredici Mesenchymal stem cells support dorsal root ganglion neurons survival by inhibiting the metalloproteinase pathway Neuroscience 172 2011 12 19
22. C. Sotelo, and R.M. Alvarado-Mallart Embryonic and adult neurons interact to allow Purkinje cell replacement in mutant cerebellum Nature 327 1987 421 423 (Pubitemid 17075814)
23. N.A. Stearns, L.R. Schaevitz, H. Bowling, N. Nag, U.V. Berger, and J. Berger-Sweeney Behavioral and anatomical abnormalities in Mecp2 mutant mice: a model for Rett syndrome Neuroscience 146 2007 907 921 (Pubitemid 46694130)
24. M. Tanabe, T. Nakano, M. Honda, and H. Ono Glycine transporter blockade ameliorates motor ataxia in a mouse model of spinocerebellar atrophy J. Pharmacol. Sci. 109 2009 444 448
25. Y. Tatsuoka, Y. Kato, and H. Imura Effect of DN-1417, a synthetic thyrotropin-releasing hormone analogue, on [3H]GABA binding in the cerebellum of ataxic rats Neurosci. Lett. 53 1985 63 68 (Pubitemid 15198904)
26. H.A. Teive Spinocerebellar ataxias Arq. Neuropsiquiatr. 67 2009 1133 1142
27. D.L. Troyer, and M.L. Weiss Wharton's jelly-derived cells are a primitive stromal cell population Stem Cells 26 2008 591 599
28. P.J. Vig, S.H. Subramony, D.R. D'Souza, J. Wei, and M.E. Lopez Intranasal administration of IGF-I improves behavior and Purkinje cell pathology in SCA1 mice Brain Res. Bull. 69 2006 573 579
29. K. Wakabayashi, A. Nagai, A.M. Sheikh, Y. Shiota, D. Narantuya, T. Watanabe, J. Masuda, S. Kobayashi, S.U. Kim, and S. Yamaguchi Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model J. Neurosci. Res. 88 2010 1017 1025
30. H.S. Wang, S.C. Hung, S.T. Peng, C.C. Huang, H.M. Wei, Y.J. Guo, Y.S. Fu, M.C. Lai, and C.C. Chen Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord Stem Cells 22 2004 1330 1337
31. K. Watase, J.R. Gatchel, Y. Sun, E. Emamian, R. Atkinson, R. Richman, H. Mizusawa, H.T. Orr, C. Shaw, and H.Y. Zoghbi Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model PLoS Med. 4 2007 e182
32. M.L. Weiss, S. Medicetty, A.R. Bledsoe, R.S. Rachakatla, M. Choi, S. Merchav, Y. Luo, M.S. Rao, G. Velagaleti, and D. Troyer Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease Stem Cells 24 2006 781 792 (Pubitemid 44464783)
33. A. Wick, W. Wick, J. Waltenberger, M. Weller, J. Dichgans, and J.B. Schulz Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt J. Neurosci. 22 2002 6401 6407 (Pubitemid 35386396)
34. C.C. Yang, Y.H. Shih, M.H. Ko, S.Y. Hsu, H. Cheng, and Y.S. Fu Transplantation of human umbilical mesenchymal stem cells from Wharton's jelly after complete transection of the rat spinal cord PLoS One 3 2008 e3336
35. P. Ye, Y. Xing, Z. Dai, and A.J. D'Ercole In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: evidence that IGF-I increases proliferation of granule cell progenitors Brain Res. Dev. Brain Res. 95 1996 44 54 (Pubitemid 26259821)
36. J. Zhang, Y. Li, J. Chen, M. Yang, M. Katakowski, M. Lu, and M. Chopp Expression of insulin-like growth factor 1 and receptor in ischemic rats treated with human marrow stromal cells Brain Res. 1030 2004 19 27 (Pubitemid 39563824)
37. J. Zhang, Y. Li, J. Chen, Y. Cui, M. Lu, S.B. Elias, J.B. Mitchell, L. Hammill, P. Vanguri, and M. Chopp Human bone marrow stromal cell treatment improves neurological functional recovery in EAE mice Exp. Neurol. 195 2005 16 26 (Pubitemid 41116810)
38. J. Zhang, Y. Li, M. Lu, Y. Cui, J. Chen, L. Noffsinger, S.B. Elias, and M. Chopp Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis mice J. Neurosci. Res. 84 2006 587 595 (Pubitemid 44196699)
39. J. Zhong, J. Deng, J. Phan, S. Dlouhy, H. Wu, W. Yao, P. Ye, A.J. D'Ercole, and W.H. Lee Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice J. Neurosci. Res. 80 2005 481 490 (Pubitemid 40780808)