Netrin-1-treated macrophages protect the kidney against ischemia-reperfusion injury and suppress inflammation by inducing M2 polarization

American Journal of Physiology - Renal Physiology

Volumn 304, Issue 7, 2013, Pages

  Ranganathan, Punithavathi Vilapakkam ^a   Jayakumar, Calpurnia ^a   Ramesh, Ganesan ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Acute kidney injury; Ischemia reperfusion injury; Macrophage polarization; Netrin 1; PPAR

Indexed keywords

ARGINASE 1; CYCLOOXYGENASE 2; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; MANNOSE RECEPTOR; NETRIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; 2 CHLORO 5 NITROBENZANILIDE; 2-CHLORO-5-NITROBENZANILIDE; ANILIDE; ANILINE DERIVATIVE; GSK 3987; MALEIMIDE DERIVATIVE; NERVE GROWTH FACTOR; NETRIN-1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TUMOR SUPPRESSOR PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL POLARITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KIDNEY; MACROPHAGE; MACROPHAGE POLARIZATION; MEDIATOR RELEASE; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RENAL PROTECTION; REPERFUSION INJURY; SPLEEN; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; KIDNEY DISEASE; MACROPHAGE ACTIVATION; MALE; METABOLISM; PATHOLOGY; PERITONEUM MACROPHAGE; TRANSGENIC MOUSE;

ANILIDES; ANILINE COMPOUNDS; ANIMALS; INFLAMMATION; INTERFERON-GAMMA; KIDNEY; KIDNEY DISEASES; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; MALEIMIDES; MICE; MICE, TRANSGENIC; NERVE GROWTH FACTORS; PPAR GAMMA; PPAR-BETA; REPERFUSION INJURY; SPLEEN; TUMOR SUPPRESSOR PROTEINS;

MLCS; MLOWN;

EID: 84878217112     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00580.2012     Document Type: Article

References (24)

1. Chawla A. Control of macrophage activation and function by PPARs. Circ Res 106: 1559-1569, 2010.
2. Daynes RA, Jones DC. Emerging roles of PPARS in inflammation and immunity. Nat Rev Immunol 2: 748-759, 2002.
3. Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity 32: 593-604, 2010.
4. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 3: 23-35, 2003.
5. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 5: 953-964, 2005.
6. Grenz A, Dalton JH, Bauerle JD, Badulak A, Ridyard D, Gandjeva A, Aherne CM, Brodsky KS, Kim JH, Tuder RM, Eltzschig HK. Partial netrin-1 deficiency aggravates acute kidney injury. PLos One 6: e14812, 2011.
7. Lee S, Huen S, Nishio H, Nishio S, Lee HK, Choi BS, Ruhrberg C, Cantley LG. Distinct macrophage phenotypes contribute to kidney injury and repair. J Am Soc Nephrol 22: 317-326, 2011.
8. Li L, Huang L, Sung Ss Vergis AL, Rosin DL, Rose CE Jr, Lobo PI, Okusa MD. The chemokine receptors CCR2 and CX3CR1 mediate monocyte//macrophage trafficking in kidney ischemia-reperfusion injury. Kidney Int 74: 1526-1537, 2008.
9. Li L, Okusa MD. Macrophages, dendritic cells, and kidney ischemia-reperfusion injury. Seminars Nephrol 30: 268-277, 2010.
10. Ly NP, Komatsuzaki K, Fraser IP, Tseng AA, Prodhan P, Moore KJ, Kinane TB. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci USA 102: 14729-14734, 2005.
11. Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity 23: 344-346, 2005.
12. Mohamed R, Jayakumar C, Ranganathan PV, Ganapathy V, Ramesh G. Kidney proximal tubular epithelial-specific overexpression of netrin-1 suppresses inflammation and albuminuria through suppression of COX-2-mediated PGE2 production in streptozotocin-induced diabetic mice. Am J Pathol 181: 1991-2002, 2012.
13. Rajasundari A, Pays L, Mehlen P, Ramesh G. Netrin-1 overexpression in kidney proximal tubular epithelium ameliorates cisplatin nephrotoxic-ity. Lab Invest 91: 1717-1726, 2011.
14. Ramesh G, Reeves WB. p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice. Am J Physiol Renal Physiol 289: F166 -F174, 2005.
15. Ramesh G, Reeves WB. p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice. Am J Physiol Renal Physiol 289: F166-F174, 2005.
16. Ranganathan P, Jayakumar C, Ramesh G. Kidney epithelial cells netrin-1 suppresses AKI-induced interstitial fibrosis and glomerulosclero-sis through suppression of IL-6/STAT3 signaling. Am J Physiol Renal Physiol. (First published February 13, 2013). doi:10.1152/ajprenal.00650.2012)
17. Reeves WB, Kwon O, Ramesh G. Netrin-1 and kidney injury. II. Netrin-1 is an early biomarker of acute kidney injury. Am J Physiol Renal Physiol 294: F731-F738, 2008.
18. Sica A, Schioppa T, Mantovani A, Allavena P. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 42: 717-727, 2006.
19. Szanto A, Balint BL, Nagy ZS, Barta E, Dezso B, Pap A, Szeles L, Poliska S, Oros M, Evans RM, Barak Y, Schwabe J, Nagy L. STAT6 transcription factor is a facilitator of the nuclear receptor PPAR-regulated Gene expression in macrophages and dendritic cells. Immunity 33: 699-712, 2010.
20. Tadagavadi RK, Wang W, Ramesh G. Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. J Immunol 185: 3750-3758, 2010.
21. Wang W, Brian RW, Ramesh G. Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney. Am J Physiol Renal Physiol 294: F739-F747, 2008.
22. Wang W, Reeves WB, Pays L, Mehlen P, Ramesh G. Netrin-1 over-expression protects kidney from ischemia reperfusion injury by suppressing apoptosis. Am J Pathol 175: 1010-1018, 2009.
23. Wang W, Reeves WB, Ramesh G. Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor. Am J Physiol Renal Physiol 296: F723-F729, 2009.
24. Wang Y, Harris DCH. Macrophages in Renal Disease. J Am Soc Nephrol 22: 21-27, 2011.