Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen

Oncotarget

Volumn 6, Issue 8, 2015, Pages 5978-5989

  Tiwana, Gaganpreet S ^a   Prevo, Remko ^a   Buffa, Francesca M ^a   Yu, Sheng ^a   Ebner, Daniel V ^b   Howarth, Alison ^b   Folkes, Lisa K ^a   Budwal, Balam ^a   Chu, Kwun Ye ^a   Durrant, Lisa ^a   Muschel, Ruth J ^a   McKenna, W Gillies ^a   Higgins, Geoff S ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

High throughput screening; Thiamine; TPK1; Tumor radiosensitivity

Indexed keywords

CARRIER PROTEIN; DNA; PYRITHIAMINE; SMALL INTERFERING RNA; THIAMINE; THIAMINE PYROPHOSPHOKINASE; THIAMINE PYROPHOSPHOKINASE 1; THIAMINE TRANSPORTER 1; UNCLASSIFIED DRUG; RADIOSENSITIZING AGENT;

ARTICLE; CANCER CELL; CELL SPECIFICITY; CLONOGENIC ASSAY; COLONY FORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENE LIBRARY; GENE SILENCING; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; RADIATION DOSE; RADIOSENSITIVITY; RADIOSENSITIZATION; VITAMIN METABOLISM; CFU COUNTING; HCT 116 CELL LINE; HELA CELL LINE; METABOLISM; NEOPLASMS; RADIATION TOLERANCE; TUMOR CELL LINE;

CELL LINE, TUMOR; COLONY-FORMING UNITS ASSAY; DNA DAMAGE; HCT116 CELLS; HELA CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NEOPLASMS; PYRITHIAMINE; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; THIAMIN PYROPHOSPHOKINASE; THIAMINE; TRANSFECTION;

EID: 84925672873     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3468     Document Type: Article

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