Combination of active components of Xiexin decoction ameliorates renal fibrosis through the inhibition of NF-κB and TGF-β1/Smad pathways in db/db diabetic mice

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Wu, Jia Sheng ^a   Shi, Rong ^a   Lu, Xiong ^a   Ma, Yue Ming ^a   Cheng, Neng Neng ^b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; COPTIDIS RHIZOME ALKALOID; CREATININE; GLUCOSE; HERBACEOUS AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; LIPID; METFORMIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RHEI RADIX AND RHIZOME POLYSACCHARIDE; SCUTELLARIA RADIX FLAVONE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PRIMER DNA; SMAD PROTEIN; XIEXIN DECOCTION;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CREATININE CLEARANCE; DIABETIC NEPHROPATHY; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; GLUCOSE METABOLISM; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FIBROSIS; LIPID METABOLISM; LOW DRUG DOSE; MALE; MESANGIUM CELL; MOUSE; NEPHRITIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANALYSIS OF VARIANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ELECTRON MICROSCOPY; FIBROSIS; GENETICS; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASES; MUTANT MOUSE STRAIN; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS; SCUTELLARIA;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; DNA PRIMERS; DRUGS, CHINESE HERBAL; FIBROSIS; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASES; MICE; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON; NF-KAPPA B; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84925637166     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122661     Document Type: Article

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