Nuclear NF-κB p65 in peripheral blood mononuclear cells correlates with urinary MCP-1, RANTES and the severity of type 2 diabetic nephropathy

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Yi, Bin ^a   Hu, Xiaofang ^a   Zhang, Hao ^a   Huang, Jing ^a   Liu, Jishi ^a   Hu, Jing ^a   Li, Wei ^a   Huang, Lihua ^a  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TRANSCRIPTION FACTOR RELA; BIOLOGICAL MARKER; CCL2 PROTEIN, HUMAN; CCL5 PROTEIN, HUMAN; RELA PROTEIN, HUMAN;

ADULT; ALBUMINURIA; ANALYTICAL PARAMETERS; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; FEMALE; GENE EXPRESSION; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; REAL TIME POLYMERASE CHAIN REACTION; URINARY ALBUMIN TO CREATININE RATIO; WESTERN BLOTTING; AGED; CASE CONTROL STUDY; CELL NUCLEUS; COMPLICATION; GENETICS; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PATHOLOGY; SEVERITY OF ILLNESS INDEX; URINE;

AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CELL NUCLEUS; CHEMOKINE CCL2; CHEMOKINE CCL5; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FEMALE; GENE EXPRESSION; GLOMERULAR FILTRATION RATE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; TRANSCRIPTION FACTOR RELA;

EID: 84903292684     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099633     Document Type: Article

References (22)

1. Wu CC, Chen JS, Lu KC, Chen CC, Lin SH, et al. (2010) Aberrant cytokines/chemokines production correlate with proteinuria in patients with overt diabetic nephropathy. Clin Chim Acta 411: 700-704.
2. Collins AJ, Foley RN, Chavers B, Gilbertson D, Herzog C, et al. (2012) 'United States Renal Data System 2011 Annual Data Report: Atlas of chronic kidney disease & end-stage renal disease in the United States. Am J Kidney Dis 59: A7, e1-420.
3. Chen HM, Shen WW, Ge YC, Zhang YD, Xie HL, et al. (2013) The relationship between obesity and diabetic nephropathy in China. BMC Nephrol 14: 69.
4. Afkarian M, Sachs MC, Kestenbaum B, Hirsch IB, Tuttle KR, et al. (2013) Kidney disease and increased mortality risk in type 2 diabetes. J Am Soc Nephrol 24: 302-308.
5. Navarro-Gonzalez JF, Mora-Fernandez C, Muros de Fuentes M, Garcia-Perez J (2011) Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy. Nat Rev Nephrol 7: 327-340.
6. Luis-Rodriguez D, Martinez-Castelao A, Gorriz JL, De-Alvaro F, Navarro-Gonzalez JF (2012) Pathophysiological role and therapeutic implications of inflammation in diabetic nephropathy. World J Diabetes 3: 7-18.
7. Ruster C, Wolf G (2008) The role of chemokines and chemokine receptors in diabetic nephropathy. Front Biosci 13: 944-955. (Pubitemid 351594739)
8. Ricardo SD, van Goor H, Eddy AA (2008) Macrophage diversity in renal injury and repair. J Clin Invest 118: 3522-3530.
9. Zhang Z, Yuan W, Sun L, Szeto FL, Wong KE, et al. (2007) 1,25-Dihydroxyvitamin D3 targeting of NF-kappaB suppresses high glucose-induced MCP-1 expression in mesangial cells. Kidney Int 72: 193-201. (Pubitemid 47067389)
10. Dai C, Wen X, He W, Liu Y (2011) Inhibition of proinflammatory RANTES expression by TGF-beta1 is mediated by glycogen synthase kinase-3beta-dependent beta-catenin signaling. J Biol Chem 286: 7052-7059.
11. Wu J, Guan TJ, Zheng S, Grosjean F, Liu W, et al. (2011) Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice. Lab Invest 91: 1459-1471.
12. KDOQI. (2007) KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease. Am J Kidney Dis 49: S12-154.
13. Mezzano S, Aros C, Droguett A, Burgos ME, Ardiles L, et al. (2004) NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy. Nephrol Dial Transplant 19: 2505-2512. (Pubitemid 39360096)
14. Chen P, Chen JB, Chen WY, Zheng QL, Wang YQ, et al. (2012) [Effects of quercetin on nuclear factor-kappaB p65 expression in renal ubiquitin-proteasome system of diabetic rats]. Zhonghua Nei Ke Za Zhi 51: 460-465.
15. Hofmann MA, Schiekofer S, Isermann B, Kanitz M, Henkels M, et al. (1999) Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. Diabetologia 42: 222-232. (Pubitemid 29064245)
16. Kim JE, Lee MH, Nam DH, Song HK, Kang YS, et al. (2013) Celastrol, an NF-kappaB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice. PLoS One 8: e62068.
17. Tam FW, Riser BL, Meeran K, Rambow J, Pusey CD, et al. (2009) Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy. Cytokine 47: 37-42.
18. Wang QY, Chen FQ (2009) Clinical significance and different levels of urinary monocyte chemoattractant protein-1 in type 2 diabetes mellitus. Diabetes Res Clin Pract 83: 215-219.
19. Bondar IA, Klimontov VV, Nadeev AP (2008) [Urinary excretion of proinflammatory cytokines and transforming growth factor beta at early stages of diabetic nephropathy]. Ter Arkh 80: 52-56.
20. Tan X, Wen X, Liu Y (2008) Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling. J Am Soc Nephrol 19: 1741-1752.
21. Amann B, Tinzmann R, Angelkort B (2003) ACE inhibitors improve diabetic nephropathy through suppression of renal MCP-1. Diabetes Care 26: 2421-2425. (Pubitemid 36993337)
22. Takebayashi K, Matsumoto S, Aso Y, Inukai T (2006) Aldosterone blockade attenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicated by diabetic nephropathy. J Clin Endocrinol Metab 91: 2214-2217. (Pubitemid 43855008)