A hyaluronic acid-based compound inhibits fibroblast senescence induced by oxidative stress in vitro and prevents oral mucositis in vivo

Journal of Cellular Physiology

Volumn 230, Issue 7, 2015, Pages 1421-1429

  Cirillo, Nicola ^a   Vicidomini, Antonio ^b   Mccullough, Michael ^a   Gambardella, Antonio ^b   Hassona, Yazan ^c   Prime, Stephen S ^d   Colella, Giuseppe ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF JORDAN   (Jordan)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; ANTIOXIDANT; BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HYALURONIC ACID DERIVATIVE; MUCOSAMIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CISPLATIN; DOXORUBICIN; HYALURONIC ACID;

ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVITY; CELL AGING; CELL MIGRATION; CELL PROLIFERATION; CELL SHAPE; CELL VIABILITY; CHEMORADIOTHERAPY; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFICACY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; ORAL MUCOSITIS; OXIDATIVE STRESS; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; WOUND HEALING; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; CELL MOTION; CHEMISTRY; CLINICAL TRIAL; DRUG EFFECTS; KERATINOCYTE; MOUTH NEOPLASMS; STOMATITIS; TIME;

AGED; ANTINEOPLASTIC AGENTS; CELL MOVEMENT; CHEMORADIOTHERAPY; CISPLATIN; DOXORUBICIN; FEMALE; FIBROBLASTS; HUMANS; HYALURONIC ACID; KERATINOCYTES; MALE; MIDDLE AGED; MOUTH NEOPLASMS; OXIDATIVE STRESS; RADIOTHERAPY; STOMATITIS; TIME FACTORS;

EID: 84925617557     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24908     Document Type: Article

References (34)

1. Buchsel PC. 2008. Polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair): A bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions. Expert Opin Drug Metab Toxicol 4:1449-1454.
2. Chattopadhyay S, Saha A, Azam M, Mukherjee A, Sur PK. 2014. Role of oral glutamine in alleviation and prevention of radiation-induced oral mucositis: A prospective randomized study. South Asian J Cancer 3:8-12.
3. Chernyavsky AI, Arredondo J, Marubio LM, Grando SA. 2004. Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes. J Cell Sci. 117:5665-5679.
4. Cirillo N, Lanza M, Femiano F, Gaeta GM, De Rosa A, Gombos F, Lanza A. 2007a. If pemphigus vulgaris IgG are the cause of acantholysis, new IgG-independent mechanisms are the concause. J Cell Physiol 212:563-567.
5. Cirillo N, Gombos F, Lanza A. 2007b. Changes in desmoglein 1 expression and subcellular localization in cultured keratinocytes subjected to antidesmoglein 1 pemphigus autoimmunity. J Cell Physiol 210:411-416.
6. Cirillo N, Hassona Y, Pignatelli M, Gasparoto TH, Morgan DJ, Prime SS. 2012. Characterization of a novel oral glucocorticoid system and its possible role in disease. J Dent Res 91:97-103.
7. Cirillo N, Lanza A, Prime SS. 2010. Induction of hyper-adhesion attenuates autoimmune-induced keratinocyte cell-cell detachment and processing of adhesion molecules via mechanisms that involve PKC. Exp Cell Res 316:580-592.
8. Colella G, Vicidomini A, Soro V, Lanza A, Cirillo N. 2012. Molecular insights into the effects of sodium hyaluronate preparations in keratinocytes. Clin Exp Dermatol 37:516-520.
9. Colella G, Cannavale R, Vicidomini A, Rinaldi G, Compilato D, Campisi G. 2010. Efficacy of a spray compound containing a pool of collagen precursor synthetic aminoacids (l-proline, l-leucine, l-lysine and glycine) combined with sodium hyaluronate to manage chemo/radiotherapy-induced oral mucositis: Preliminary data of an open trial. Int J Immunopathol Pharmacol 23:143-151.
10. Criswell T, Leskov K, Miyamoto S, Luo G, Boothman DA. 2003. Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation. Oncogene 22:5813-5827.
11. Elting LS, Keefe DM, Sonis ST, Garden AS, Spijkervet FK, Barasch A, Tishler RB, Canty TP, Kudrimoti MK, Vera-Llonch M. Burden of Illness Head and Neck Writing Committee. 2008. Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy: Demonstration of increased frequency, severity, resistance to palliation, and impact on quality of life. Cancer 113:2704-2713.
12. Favia G, Mariggio MA, Maiorano F, Cassano A, Capodiferro S, Ribatti D. 2008. Accelerated wound healing of oral soft tissues and angiogenic effect induced by a pool of aminoacids combined to sodium hyaluronate (AMINOGAM). J Biol Regul Homeost Agents 22:109-116.
13. Hassona Y, Cirillo N, Lim KP, Herman A, Mellone M, Thomas GJ, Pitiyage GN, Parkinson EK, Prime SS. 2013. Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-β. Carcinogenesis 34:1286-1295.
14. Hassona Y, Cirillo N, Heesom K, Parkinson EK, Prime SS. 2014. Senescent cancer associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion. Br J Cancer 111:1230-1237.
15. Laberge RM, Awad P, Campisi J, Desprez PY. 2012. Epithelial-mesenchymal transition induced by senescent fibroblasts. Cancer Microenviron 5:39-44.
16. Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, McGuire DB, Migliorati C, Nicolatou-Galitis O, Peterson DE, Raber-Durlacher JE, Sonis ST. Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO). 2014. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120:1453-1461.
17. Li JM, Chou HC, Wang SH, Wu CL, Chen YW, Lin ST, Chen YH, Chan HL. 2013. Hyaluronic acid-dependent protection against UVB-damaged human corneal cells. Environ Mol Mutagen 54:429-449.
18. Lim KP, Cirillo N, Hassona Y, Wei W, Thurlow JK, Cheong SC, Pitiyage G, Parkinson EK, Prime SS. 2011. Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma. J Pathol 223:459-469.
19. Lockington D, Agarwal P, Young D, Caslake M, Ramaesh K. 2014. Antioxidant properties of amniotic membrane: Novel observations from a pilot study. Can J Ophthalmol 49:426-430.
20. Mariggiò MA, Cassano A, Vinella A, Vincenti A, Fumarulo R, Lo Muzio, Maiorano L, Ribatti E, Favia D. 2009. Enhancement of fibroblast proliferation, collagen biosynthesis and production of growth factors as a result of combining sodium hyaluronate and aminoacids. Int J Immunopathol Pharmacol 22:485-492.
21. Mendoza G, Alvarez AI, Pulido MM, Molina AJ, Merino G, Real R, Fernandes P, Prieto JG. 2007. Inhibitory effects of different antioxidants on hyaluronan depolymerization. Carbohydr Res 342:96-102.
22. Nonzee NJ, Dandade NA, Patel U, Markossian T, Agulnik M, Argiris A, Patel JD, Kern RC, Munshi HG, Calhoun EA, Bennett CL. 2008. Evaluating the supportive care costs of severe radiochemotherapy-induced mucositis and pharyngitis: Results from a Northwestern University Costs of Cancer Program pilot study with head and neck and nonsmall cell lung cancer patients who received care at a county hospital, a Veterans Administration hospital, or a comprehensive cancer care center. Cancer 113:1446-1452.
23. Parrinello S, Coppe JP, Krtolica A, Campisi J. 2005. Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation. J Cell Sci 118:485-496.
24. Pauloski BR, Rademaker AW, Logemann JA, Lundy D, Bernstein M, McBreen C, Santa D, Campanelli A, Kelchner L, Klaben B, Discekici-Harris M. 2011. Relation of mucous membrane alterations to oral intake during the first year after treatment for head and neck cancer. Head Neck 33:774-779.
25. Raber-Durlacher JE, von Bültzingslöwen I, Logan RM, Bowen J, Al-Azri AR, Everaus H, Gerber E, Gomez JG, Pettersson BG, Soga Y, Spijkervet FK, Tissing WJ, Epstein JB, Elad S, Lalla RV. Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). 2013. Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients. Support Care Cancer 21:343-355.
26. Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez JY, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A. 2012. Fiji: An open-source platform for biological-image analysis. Nat Methods 9:676-682.
27. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, Bekele BN, Raber-Durlacher J, Donnelly JP, Rubenstein EB. Mucositis Study Section of the Multinational Association for Supportive Care in Cancer; International Society for Oral Oncology. 2004. Perspectives on cancer therapy-induced mucosal injury: Pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100:1995-2025.
28. Sonis ST. 2009. Mucositis: The impact, biology and therapeutic opportunities of oral mucositis. Oral Oncol 45:1015-1020.
29. Sonis ST. 2011. Oral mucositis. Anticancer Drugs 22:607-612.
30. Stokman MA, Spijkervet FK, Boezen HM, Schouten JP, Roodenburg JL, de Vries EG. 2006. Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: Results of meta-analyses. J Dent Res 85:690-700.
31. Talwar S, House R, Sundaramurthy S, Balasubramanian S, Yu H, Palanisamy V. 2014. Inhibition of caspases protects mice from radiation-induced oral mucositis and abolishes the cleavage of RNA-binding protein HuR. J Biol Chem 289:3487-3500.
32. Trotti A, Bellm LA, Epstein JB, Frame D, Fuchs HJ, Gwede CK, Komaroff E, Nalysnyk L, Zilberberg MD. 2003. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review. Radiother Oncol 66:253-262.
33. Yoshino F, Yoshida A, Nakajima A, Wada-Takahashi S, Takahashi SS, Lee MC. 2013. Alteration of the redox state with reactive oxygen species for 5-fluorouracil-induced oral mucositis in hamsters. PLoS ONE 8:e82834.
34. Zhao W, Robbins ME. 2009. Inflammation and chronic oxidative stress in radiationinduced late normal tissue injury: Therapeutic implications. Curr Med Chem 16:130-143.