Amelioration of human osteoarthritis symptoms with topical ‘biotherapeutics’: a phase I human trial

Cell Stress and Chaperones

Volumn 20, Issue 2, 2015, Pages 267-276

  Mahmoud, Fadia F ^a   Al Awadhi, Adel M ^a   Haines, David D ^b  

^a KUWAIT UNIVERSITY   (Kuwait)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Biotherapeutic agent; Cytokines; Heme oxygenase 1; Inflammation; Osteoarthritis; Sour cherry

Indexed keywords

ANTIRHEUMATIC AGENT; C REACTIVE PROTEIN; CD4 ANTIGEN; CHERRY SEED EXTRACT; GAMMA INTERFERON; HEME OXYGENASE 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE;

ARTHRALGIA; ARTICLE; CD4+ T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; KNEE OSTEOARTHRITIS; LEUKOCYTE COUNT; OSTEOARTHRITIS; OXIDATIVE STRESS; PAIN ASSESSMENT; PATHOGENESIS; PHASE 1 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TREATMENT OUTCOME; ADULT; CELL CULTURE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED STUDY; CYTOLOGY; DRUG ADMINISTRATION; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PAIN MEASUREMENT; PATHOLOGY; PHASE 1 CLINICAL TRIAL; PLACEBO EFFECT; PLANT SEED; PRUNUS; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; SEVERITY OF ILLNESS INDEX; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ADULT; C-REACTIVE PROTEIN; CELLS, CULTURED; CYTOKINES; DRUG ADMINISTRATION SCHEDULE; HEME OXYGENASE-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MIDDLE AGED; OSTEOARTHRITIS; PAIN MEASUREMENT; PLACEBO EFFECT; PLANT EXTRACTS; PRUNUS; SEEDS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84925541063     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-014-0553-0     Document Type: Article

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